CA2373547A1 - Methodes d'induction de tolerance a des vecteurs adenoviraux et a des produits transgeniques - Google Patents
Methodes d'induction de tolerance a des vecteurs adenoviraux et a des produits transgeniques Download PDFInfo
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- CA2373547A1 CA2373547A1 CA002373547A CA2373547A CA2373547A1 CA 2373547 A1 CA2373547 A1 CA 2373547A1 CA 002373547 A CA002373547 A CA 002373547A CA 2373547 A CA2373547 A CA 2373547A CA 2373547 A1 CA2373547 A1 CA 2373547A1
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Abstract
L'invention concerne une méthode d'induction de la tolérance à un vecteur adénoviral et/ou à un produit transgénique chez un hôte, ce qui favorise une expression transgénique persistante chez l'hôte et permet d'effectuer une administration répétée du vecteur à l'hôte tout en réduisant ou en supprimant la réponse immunitaire de l'hôte. La méthode consiste à effectuer un prétraitement d'un hôte en lui administrant des cellules présentatrices de l'antigène infectées par un vecteur adénoviral, ce vecteur adénoviral comprenant des acides nucléiques hétérologues codant pour une molécule immunomodulatrice et un transgène et ces cellules présentatrices de l'antigène infectées par un vecteur adénoviral migrant vers les organes lymphoïdes et/ou les ganglions lymphatiques et induisant une tolérance. La méthode consiste également à effectuer une administration ultérieure à l'hôte d'un vecteur adénoviral comprenant un acide nucléique hétérologue codant pour le transgène selon l'invention, la réponse immunitaire de l'hôte à ce vecteur adénoviral et à ce transgène étant réduit ou supprimé, même après une nouvelle administration du vecteur adénoviral.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13627899P | 1999-05-27 | 1999-05-27 | |
| US60/136,278 | 1999-05-27 | ||
| PCT/US2000/014344 WO2000073477A1 (fr) | 1999-05-27 | 2000-05-25 | Methodes d'induction de tolerance a des vecteurs adenoviraux et a des produits transgeniques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2373547A1 true CA2373547A1 (fr) | 2000-12-07 |
Family
ID=22472151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002373547A Abandoned CA2373547A1 (fr) | 1999-05-27 | 2000-05-25 | Methodes d'induction de tolerance a des vecteurs adenoviraux et a des produits transgeniques |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1180156A1 (fr) |
| JP (1) | JP2003501040A (fr) |
| AU (1) | AU5161600A (fr) |
| CA (1) | CA2373547A1 (fr) |
| WO (1) | WO2000073477A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001027254A2 (fr) * | 1999-10-12 | 2001-04-19 | Fritz Schwarzmann | Vecteur de transfert de genes destine a la therapie de maladies auto-immunes et de maladies avec immunopathogenie |
| WO2001057228A1 (fr) * | 2000-02-02 | 2001-08-09 | Genzyme Corporation | Methodes de traitement de la restenose faisant appel a des vecteurs adenoviraux et des produits transgeniques |
| JP4237449B2 (ja) * | 2002-06-05 | 2009-03-11 | 国立医薬品食品衛生研究所長 | アデノウィルスベクター |
| DE10254374A1 (de) * | 2002-11-21 | 2004-06-03 | Universitätsklinikum Hamburg-Eppendorf Körperschaft des Öffentlichen Rechts | Adenovirale Vektoren zum Transfer von spezifischen Genen in Körperzellen |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7585998A (en) * | 1997-05-22 | 1998-12-11 | Uab Research Foundation | Controlling immune response to specific antigens |
-
2000
- 2000-05-25 WO PCT/US2000/014344 patent/WO2000073477A1/fr active Search and Examination
- 2000-05-25 AU AU51616/00A patent/AU5161600A/en not_active Abandoned
- 2000-05-25 EP EP00936276A patent/EP1180156A1/fr not_active Withdrawn
- 2000-05-25 JP JP2001500789A patent/JP2003501040A/ja active Pending
- 2000-05-25 CA CA002373547A patent/CA2373547A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1180156A1 (fr) | 2002-02-20 |
| WO2000073477A1 (fr) | 2000-12-07 |
| JP2003501040A (ja) | 2003-01-14 |
| AU5161600A (en) | 2000-12-18 |
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