CA2371279A1 - Vaccin de recombinaison contre la neurotoxine botulique - Google Patents
Vaccin de recombinaison contre la neurotoxine botulique Download PDFInfo
- Publication number
- CA2371279A1 CA2371279A1 CA002371279A CA2371279A CA2371279A1 CA 2371279 A1 CA2371279 A1 CA 2371279A1 CA 002371279 A CA002371279 A CA 002371279A CA 2371279 A CA2371279 A CA 2371279A CA 2371279 A1 CA2371279 A1 CA 2371279A1
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- serotype
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention concerne la préparation et l'expression de gènes de synthèse codant des polypeptides contenant des épitopes protecteurs de neurotoxine botulique (BoNT). L'invention porte également sur la production de peptides immunogènes codés par ces gènes de synthèse, de même que la récupération et la purification de peptides immunogènes à partir d'organismes de recombinaison. L'invention concerne enfin des procédés de vaccination contre la neurotoxine botulique utilisant les peptides exprimés.
Applications Claiming Priority (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13386999P | 1999-05-12 | 1999-05-12 | |
US13387399P | 1999-05-12 | 1999-05-12 | |
US13386699P | 1999-05-12 | 1999-05-12 | |
US13386599P | 1999-05-12 | 1999-05-12 | |
US13386799P | 1999-05-12 | 1999-05-12 | |
US13386899P | 1999-05-12 | 1999-05-12 | |
US60/133,868 | 1999-05-12 | ||
US60/133,866 | 1999-05-12 | ||
US60/133,867 | 1999-05-12 | ||
US60/133,865 | 1999-05-12 | ||
US60/133,873 | 1999-05-12 | ||
US60/133,869 | 1999-05-12 | ||
US14619299P | 1999-07-29 | 1999-07-29 | |
US60/146,192 | 1999-07-29 | ||
PCT/US2000/012890 WO2000067700A2 (fr) | 1999-05-12 | 2000-05-12 | Vaccin de recombinaison contre la neurotoxine botulique |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2371279A1 true CA2371279A1 (fr) | 2000-11-16 |
Family
ID=27568892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002371279A Abandoned CA2371279A1 (fr) | 1999-05-12 | 2000-05-12 | Vaccin de recombinaison contre la neurotoxine botulique |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1180999A4 (fr) |
JP (1) | JP2004512004A (fr) |
AU (1) | AU783450B2 (fr) |
CA (1) | CA2371279A1 (fr) |
WO (1) | WO2000067700A2 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7227010B2 (en) * | 1993-09-21 | 2007-06-05 | United States Of America As Represented By The Secretary Of The Army | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy |
US7037680B2 (en) * | 1993-09-21 | 2006-05-02 | The United States Of America As Represented By The Secretary Of The Army | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy |
WO2003012117A1 (fr) * | 2001-07-28 | 2003-02-13 | The Secretary Of State For Defence | Vaccin a adn |
WO2006011966A1 (fr) | 2004-06-30 | 2006-02-02 | Allergan, Inc. | Optimisation d'expression de toxine botulinum active de type e |
EP1773874B1 (fr) * | 2004-08-04 | 2012-10-24 | Allergan, Inc. | Optimisation de l'expression de toxine botulinique active de type a |
FR2889066B1 (fr) * | 2005-07-28 | 2007-11-09 | Centre Nat Rech Scient | Procede d'immunisation genetique par electrotransfert contre une toxine et antiserum susceptible d'etre obtenu par ledit procede |
JP2009106163A (ja) * | 2007-10-26 | 2009-05-21 | Kyushu Univ | 核酸配列、ベクター、形質転換体、製造方法、及び、核酸配列プライマー |
RU2545825C9 (ru) | 2009-10-21 | 2015-06-20 | Мерц Фарма Гмбх Унд Ко. Кгаа | Система для определения непроцессированного и частично процессированного нейротоксина типа а |
GB201312317D0 (en) * | 2013-07-09 | 2013-08-21 | Syntaxin Ltd | Cationic neurotoxins |
GB201407525D0 (en) * | 2014-04-29 | 2014-06-11 | Syntaxin Ltd | Manufacture of recombinant clostridium botulinum neurotoxins |
EP3822286A1 (fr) | 2015-01-09 | 2021-05-19 | Ipsen Bioinnovation Limited | Neurotoxines cationiques |
JP6910961B2 (ja) * | 2015-05-15 | 2021-07-28 | ヌーテック ベンチャーズ | 選択細胞への分子送達に適用する遺伝子操作したボツリヌス菌毒素 |
EP3728296A1 (fr) * | 2017-12-20 | 2020-10-28 | Allergan, Inc. | Polypeptides du domaine de liaison cellulaire de toxine botulique et procédés d'utilisation pour le rajeunissement de la peau |
CN110075288B (zh) * | 2019-05-06 | 2022-04-26 | 中国兽医药品监察所 | 一种无毒c型肉毒梭菌基因工程亚单位疫苗及其生产方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9511909D0 (en) * | 1995-06-12 | 1995-08-09 | Microbiological Res Authority | Vaccine |
-
2000
- 2000-05-12 EP EP00932296A patent/EP1180999A4/fr not_active Ceased
- 2000-05-12 CA CA002371279A patent/CA2371279A1/fr not_active Abandoned
- 2000-05-12 JP JP2000616731A patent/JP2004512004A/ja active Pending
- 2000-05-12 WO PCT/US2000/012890 patent/WO2000067700A2/fr active IP Right Grant
- 2000-05-12 AU AU50035/00A patent/AU783450B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU783450B2 (en) | 2005-10-27 |
AU5003500A (en) | 2000-11-21 |
JP2004512004A (ja) | 2004-04-22 |
EP1180999A2 (fr) | 2002-02-27 |
WO2000067700A2 (fr) | 2000-11-16 |
EP1180999A4 (fr) | 2005-03-30 |
WO2000067700A3 (fr) | 2001-02-08 |
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