CA2370801A1 - 1,5-benzodiazepine derivatives as cck-a receptor agonists - Google Patents

1,5-benzodiazepine derivatives as cck-a receptor agonists Download PDF

Info

Publication number
CA2370801A1
CA2370801A1 CA002370801A CA2370801A CA2370801A1 CA 2370801 A1 CA2370801 A1 CA 2370801A1 CA 002370801 A CA002370801 A CA 002370801A CA 2370801 A CA2370801 A CA 2370801A CA 2370801 A1 CA2370801 A1 CA 2370801A1
Authority
CA
Canada
Prior art keywords
cck
compound
enantiomer
phenyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002370801A
Other languages
English (en)
French (fr)
Inventor
David Colclough
Anne Hodgson
Jerzy Ryszard Szewczyk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9910366.5A external-priority patent/GB9910366D0/en
Priority claimed from GBGB0008179.4A external-priority patent/GB0008179D0/en
Application filed by Individual filed Critical Individual
Publication of CA2370801A1 publication Critical patent/CA2370801A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002370801A 1999-05-06 2000-05-04 1,5-benzodiazepine derivatives as cck-a receptor agonists Abandoned CA2370801A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9910366.5 1999-05-06
GBGB9910366.5A GB9910366D0 (en) 1999-05-06 1999-05-06 1,5-Benzodiazepine Derivatives
GB0008179.4 2000-04-05
GBGB0008179.4A GB0008179D0 (en) 2000-04-05 2000-04-05 Chemical process
PCT/EP2000/003982 WO2000068209A2 (en) 1999-05-06 2000-05-04 1,5-benzodiazepine derivatives as cck-a receptor agonists

Publications (1)

Publication Number Publication Date
CA2370801A1 true CA2370801A1 (en) 2000-11-16

Family

ID=26244033

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002370801A Abandoned CA2370801A1 (en) 1999-05-06 2000-05-04 1,5-benzodiazepine derivatives as cck-a receptor agonists

Country Status (21)

Country Link
EP (1) EP1212305A2 (no)
JP (1) JP2002544200A (no)
KR (1) KR20020012567A (no)
CN (1) CN1161345C (no)
AR (1) AR022044A1 (no)
AU (1) AU4754800A (no)
BR (1) BR0010338A (no)
CA (1) CA2370801A1 (no)
CO (1) CO5170461A1 (no)
CZ (1) CZ20013988A3 (no)
HK (1) HK1046138A1 (no)
HU (1) HUP0201181A3 (no)
IL (1) IL146124A0 (no)
MX (1) MXPA01011267A (no)
MY (1) MY138319A (no)
NO (1) NO20015397L (no)
NZ (1) NZ515048A (no)
PE (1) PE20010110A1 (no)
PL (1) PL351546A1 (no)
TR (1) TR200103169T2 (no)
WO (1) WO2000068209A2 (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005035793A2 (en) * 2003-10-09 2005-04-21 Decode Genetics Ehf. Cckar markers and haplotypes associated with extreme weight conditions
GEP20094723B (en) 2004-05-25 2009-07-10 Pfizer Prod Inc Tetraazabenzo [e] azulene derivatives and analogs thereof
BR112022006546A2 (pt) 2019-10-07 2022-08-30 Kallyope Inc Agonistas de gpr119

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9307833D0 (en) * 1993-04-15 1993-06-02 Glaxo Inc Modulators of cholecystokinin and gastrin

Also Published As

Publication number Publication date
JP2002544200A (ja) 2002-12-24
MXPA01011267A (es) 2002-05-06
MY138319A (en) 2009-05-29
WO2000068209A3 (en) 2001-03-01
WO2000068209A2 (en) 2000-11-16
BR0010338A (pt) 2002-02-13
EP1212305A2 (en) 2002-06-12
KR20020012567A (ko) 2002-02-16
TR200103169T2 (tr) 2002-04-22
HK1046138A1 (zh) 2002-12-27
HUP0201181A3 (en) 2003-10-28
NZ515048A (en) 2004-01-30
CZ20013988A3 (cs) 2002-02-13
AR022044A1 (es) 2002-09-04
PE20010110A1 (es) 2001-03-05
CO5170461A1 (es) 2002-06-27
IL146124A0 (en) 2002-07-25
AU4754800A (en) 2000-11-21
CN1161345C (zh) 2004-08-11
CN1362949A (zh) 2002-08-07
PL351546A1 (en) 2003-05-05
NO20015397D0 (no) 2001-11-05
HUP0201181A2 (hu) 2002-12-28
NO20015397L (no) 2001-11-05

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued