CA2361396A1 - Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs - Google Patents

Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs Download PDF

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Publication number
CA2361396A1
CA2361396A1 CA002361396A CA2361396A CA2361396A1 CA 2361396 A1 CA2361396 A1 CA 2361396A1 CA 002361396 A CA002361396 A CA 002361396A CA 2361396 A CA2361396 A CA 2361396A CA 2361396 A1 CA2361396 A1 CA 2361396A1
Authority
CA
Canada
Prior art keywords
fez1
cell
polynucleotide
protein
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002361396A
Other languages
English (en)
Inventor
Carlo M. Croce
Hideshi Ishii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thomas Jefferson University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2361396A1 publication Critical patent/CA2361396A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

L'invention concerne des homologues de polynucléotides isolés avec une partie d'un brin du gène suppresseur de tumeur de l'homme, le gène <i>FEZ1</i>. L'invention traite également de la protéine suppresseur de tumeur ainsi codée, Fezl. Ces polynucléotides présentent un grand intérêt, par exemple, comme sondes, comme amorces, comme parties de vecteurs d'expression et similaires. L'invention traite également de procédés de diagnostique, de thérapie, de prolifération cellulaire et de dosage utilisant ces polynucléotides et ces protéines. L'invention a également pour objet des kits permettant de mettre en oeuvre les procédés selon l'invention.
CA002361396A 1999-02-25 2000-02-25 Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs Abandoned CA2361396A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12153799P 1999-02-25 1999-02-25
US60/121,537 1999-02-25
PCT/US2000/004950 WO2000050565A2 (fr) 1999-02-25 2000-02-25 Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs

Publications (1)

Publication Number Publication Date
CA2361396A1 true CA2361396A1 (fr) 2000-08-31

Family

ID=22397335

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002361396A Abandoned CA2361396A1 (fr) 1999-02-25 2000-02-25 Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs

Country Status (4)

Country Link
EP (1) EP1163252A4 (fr)
JP (1) JP2003508011A (fr)
CA (1) CA2361396A1 (fr)
WO (1) WO2000050565A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141417B1 (en) 1999-02-25 2006-11-28 Thomas Jefferson University Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene
US8053186B2 (en) 2007-06-15 2011-11-08 The Ohio State University Research Foundation Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing
CN101835902B (zh) 2007-08-03 2014-03-26 俄亥俄州立大学研究基金会 编码ncrna的超保守区域
AU2008316577B2 (en) 2007-10-26 2014-04-10 The Ohio State University Research Foundation Methods for identifying fragile histidine triad (FHIT) interaction and uses thereof
AU2009257410B2 (en) 2008-06-11 2014-03-06 Fudan University Use of miR-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy
AU2010321555B2 (en) 2009-11-23 2015-10-15 The Ohio State University Materials and methods useful for affecting tumor cell growth, migration and invasion
CA2816603A1 (fr) 2010-11-12 2012-05-18 The Ohio State University Research Foundation Materiaux et procedes relatifs aux microarn-21, reparation de desappariement et cancer colorectal
AU2011329066B2 (en) 2010-11-15 2017-03-09 The Ohio State University Research Foundation Controlled release mucoadhesive systems
AU2012225506B2 (en) 2011-03-07 2016-11-17 The Ohio State University Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer
EP2766500A4 (fr) 2011-10-14 2015-10-14 Univ Ohio State Méthodes et matériaux relatifs au cancer des ovaires
US9481885B2 (en) 2011-12-13 2016-11-01 Ohio State Innovation Foundation Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
CA2866052A1 (fr) 2012-01-20 2013-07-25 The Ohio State University Signatures de marqueurs biologiques du cancer du sein concernant le pouvoir envahissant et le pronostic

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055300A2 (fr) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Acides nucleiques, proteines et anticorps
WO2001059064A2 (fr) * 2000-01-31 2001-08-16 Human Genome Sciences, Inc. Acides nucleiques, proteines et anticorps

Also Published As

Publication number Publication date
EP1163252A4 (fr) 2004-04-07
WO2000050565A3 (fr) 2000-12-07
WO2000050565A2 (fr) 2000-08-31
JP2003508011A (ja) 2003-03-04
EP1163252A2 (fr) 2001-12-19

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead