CA2348319A1 - Cyclohexenol derivative and medicament containing the same - Google Patents

Cyclohexenol derivative and medicament containing the same Download PDF

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Publication number
CA2348319A1
CA2348319A1 CA002348319A CA2348319A CA2348319A1 CA 2348319 A1 CA2348319 A1 CA 2348319A1 CA 002348319 A CA002348319 A CA 002348319A CA 2348319 A CA2348319 A CA 2348319A CA 2348319 A1 CA2348319 A1 CA 2348319A1
Authority
CA
Canada
Prior art keywords
derivative
cyclohexenol
neurocyte
same
cyclohexenol derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002348319A
Other languages
French (fr)
Other versions
CA2348319C (en
Inventor
Bang Luu
Jacquot Delphine
Celine Junges-Girlanda
Jose-Luis Gonzalez De Aguilar
Bernadette Lutz-Bucher
Jean-Philippe Loeffler
Masashi Yamada
Yukie Suma
Hiroto Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite de Strasbourg
Meiji Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002348319A priority Critical patent/CA2348319C/en
Publication of CA2348319A1 publication Critical patent/CA2348319A1/en
Application granted granted Critical
Publication of CA2348319C publication Critical patent/CA2348319C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic
    • C07C35/08—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings
    • C07C35/18—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings with unsaturation at least in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Disclosed herein are a cyclohexenol derivative represented by the following general formula (1): (see formula 1) wherein R1 to R5 are independently a methyl group or a hydrogen atom, and X is an alkylene or alkenylene group having 10 to 28 carbon atoms, and a medicament comprising the derivative as an active ingredient. The cyclohexenol derivative (1) exhibits neurocyte growth-accelerating effects such as neurocyte-growing effect and neurite-outgrowing effect and is hence useful as an agent for preventing or treating diseases caused by nervous degeneration, such as amyotrophic lateral sclerosis.
CA002348319A 2001-05-24 2001-05-24 Cyclohexenol derivative and medicament containing the same Expired - Fee Related CA2348319C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002348319A CA2348319C (en) 2001-05-24 2001-05-24 Cyclohexenol derivative and medicament containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002348319A CA2348319C (en) 2001-05-24 2001-05-24 Cyclohexenol derivative and medicament containing the same

Publications (2)

Publication Number Publication Date
CA2348319A1 true CA2348319A1 (en) 2002-11-24
CA2348319C CA2348319C (en) 2009-09-08

Family

ID=4169089

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002348319A Expired - Fee Related CA2348319C (en) 2001-05-24 2001-05-24 Cyclohexenol derivative and medicament containing the same

Country Status (1)

Country Link
CA (1) CA2348319C (en)

Also Published As

Publication number Publication date
CA2348319C (en) 2009-09-08

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20160524