CA2339371A1 - Electrically mediated angiogenesis - Google Patents

Electrically mediated angiogenesis Download PDF

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Publication number
CA2339371A1
CA2339371A1 CA002339371A CA2339371A CA2339371A1 CA 2339371 A1 CA2339371 A1 CA 2339371A1 CA 002339371 A CA002339371 A CA 002339371A CA 2339371 A CA2339371 A CA 2339371A CA 2339371 A1 CA2339371 A1 CA 2339371A1
Authority
CA
Canada
Prior art keywords
body tissue
targeted body
electrical
electrodes
electrical field
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002339371A
Other languages
French (fr)
Other versions
CA2339371C (en
Inventor
Deena Conrad-Vlasak
Terence Pertile
J. Edward Shapland
John Vanden Hoek
Robert Walsh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic ATS Medical Inc
Original Assignee
Emed Corporation
Deena Conrad-Vlasak
Terence Pertile
J. Edward Shapland
John Vanden Hoek
Robert Walsh
Em Vascular, Inc.
Ats Medical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emed Corporation, Deena Conrad-Vlasak, Terence Pertile, J. Edward Shapland, John Vanden Hoek, Robert Walsh, Em Vascular, Inc., Ats Medical, Inc. filed Critical Emed Corporation
Publication of CA2339371A1 publication Critical patent/CA2339371A1/en
Application granted granted Critical
Publication of CA2339371C publication Critical patent/CA2339371C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3627—Heart stimulators for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3629—Heart stimulators in combination with non-electric therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Electrotherapy Devices (AREA)

Abstract

This invention is an electrical stimulation apparatus for delivering an electrical field over a predetermined period of time to a targeted body tissue (150) in order to stimulate a cell initiated angiogenic response in living cells within the targeted body tissue. The electrical stimulation apparatus includes an electrical field generating unit including a power support (117), a control mechanism (119) interconnected with the power supply (117), and a plurality of electrodes (100, 120) designed to generate an electrical field proximate to the targeted body tissue. The amplitude of the electrical field delivered to or generated proximate to the targeted body tissue, and the duration of the period of delivery is sufficient to stimulate angiogenesis in the targeted body tissue. The control mechanism (119) preferably includes a computer processing unit in electronic communication with the power supply, the computer being programmed to cause the electrical stimulatation apparatus to deliver a predetermined amount of electrical current or voltage over a predetermined period of delivery to the plurality of electrodes such that the electrical stimulation apparatus can deliver such electrical current or voltage to the targeted body tissue when the plurality of electrodes are in contact or proximity with the targeted body tissue.
CA002339371A 1998-11-12 1999-11-12 Electrically mediated angiogenesis Expired - Lifetime CA2339371C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US19120998A 1998-11-12 1998-11-12
US10808098P 1998-11-12 1998-11-12
US19041298A 1998-11-12 1998-11-12
US09/190,412 1998-11-12
US09/191,209 1998-11-12
US60/108,080 1998-11-12
PCT/US1999/026834 WO2000027466A1 (en) 1998-11-12 1999-11-12 Electrically mediated angiogenesis

Publications (2)

Publication Number Publication Date
CA2339371A1 true CA2339371A1 (en) 2000-05-18
CA2339371C CA2339371C (en) 2009-04-07

Family

ID=27380410

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002339371A Expired - Lifetime CA2339371C (en) 1998-11-12 1999-11-12 Electrically mediated angiogenesis

Country Status (4)

Country Link
EP (1) EP1128866A4 (en)
AU (1) AU1620300A (en)
CA (1) CA2339371C (en)
WO (1) WO2000027466A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6560489B2 (en) 1999-08-24 2003-05-06 Em Vascular, Inc. Therapeutic device and method for treating diseases of cardiac muscle
US6556872B2 (en) 1999-08-24 2003-04-29 Ev Vascular, Inc. Therapeutic device and method for treating diseases of cardiac muscle
US6810286B2 (en) 2000-03-06 2004-10-26 Medtronic, Inc Stimulation for delivery of molecular therapy
WO2002070065A2 (en) 2001-03-05 2002-09-12 Medtronic, Inc. Stimulation for delivery of molecular therapy
US20040039417A1 (en) * 2002-04-16 2004-02-26 Medtronic, Inc. Electrical stimulation and thrombolytic therapy
AU2003297592A1 (en) * 2002-11-30 2004-06-23 Cardiac Pacemakers, Inc. Method and apparatus for cell and electrical therapy of living tissue
US9457184B2 (en) 2005-04-06 2016-10-04 Berlin Heals Holding Ag Electromedical implantable or extracorporeally applicable device for the treatment or monitoring of organs, and method for therapeutic organ treatment
US20160361559A1 (en) 2007-10-12 2016-12-15 Berlin Heals Holding Ag Electromedical implantable or extracorporeally applicable device for the treatment or monitoring of organs, and method for therapeutic organ treatment
DE102008039712A1 (en) * 2008-08-26 2010-03-04 Ullrich Und Augst Gmbh Method for regulation of biological process of human organisms on cellular plain by applying of electromagnetic field, comprises stimulating cells of biological organism with oscillation harmonious electro-magnetic oscillations
CN107206230B (en) * 2015-02-03 2021-07-27 维奥尔株式会社 Device for treating blood vessels in the skin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5499971A (en) 1990-06-15 1996-03-19 Cortrak Medical, Inc. Method for iontophoretically delivering drug adjacent to a heart
US5634899A (en) 1993-08-20 1997-06-03 Cortrak Medical, Inc. Simultaneous cardiac pacing and local drug delivery method
US5433735A (en) * 1993-09-27 1995-07-18 Zanakis; Michael F. Electrical stimulation technique for tissue regeneration
US5578022A (en) * 1995-04-12 1996-11-26 Scherson; Daniel A. Oxygen producing bandage and method
US5944710A (en) * 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery

Also Published As

Publication number Publication date
CA2339371C (en) 2009-04-07
WO2000027466A1 (en) 2000-05-18
EP1128866A1 (en) 2001-09-05
EP1128866A4 (en) 2008-11-05
AU1620300A (en) 2000-05-29

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Effective date: 20191112