CA2323866A1 - Xenogreffes osseuses - Google Patents
Xenogreffes osseuses Download PDFInfo
- Publication number
- CA2323866A1 CA2323866A1 CA002323866A CA2323866A CA2323866A1 CA 2323866 A1 CA2323866 A1 CA 2323866A1 CA 002323866 A CA002323866 A CA 002323866A CA 2323866 A CA2323866 A CA 2323866A CA 2323866 A1 CA2323866 A1 CA 2323866A1
- Authority
- CA
- Canada
- Prior art keywords
- xenograft
- bone
- article
- manufacture
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/204—Formaldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/206—Ethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Orthopedic Medicine & Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
Cette invention se rapporte à un article élaboré, comprenant une xénogreffe osseuse essentiellement non immunogène, destinée à être implantée dans le corps humain. Cette invention se rapporte également à un procédé servant à préparer une xénogreffe, en retirant au moins une partie d'un os d'un animal non humain, pour obtenir une xénogreffe (X), en lavant la xénogreffe dans une solution saline et dans de l'alcool; en soumettant cette xénogreffe à un traitement de rupture des cellules; et en traitant la xénogreffe avec une glycosidase pour éliminer les fractions hydrates de carbone de surface. Cette invention se rapporte en outre à un article élaboré produit par ce procédé. Cette invention propose également une xénogreffe osseuse destinée à être implantée dans le corps humain et comprenant une partie (10) d'un os provenant d'un animal non humain, cette partie ne contenant pour ainsi dire plus de fractions hydrates de carbone de surface susceptibles d'une digestion par la glycosidase. Chaque xénogreffe de cette invention possède pour ainsi dire les mêmes propriétés mécaniques qu'un os natif correspondant.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7813998P | 1998-03-16 | 1998-03-16 | |
US60/078,139 | 1998-03-16 | ||
US10075598P | 1998-09-17 | 1998-09-17 | |
US60/100,755 | 1998-09-17 | ||
PCT/US1999/005661 WO1999047080A1 (fr) | 1998-03-16 | 1999-03-15 | Xenogreffes osseuses |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2323866A1 true CA2323866A1 (fr) | 1999-09-23 |
Family
ID=26760147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002323866A Abandoned CA2323866A1 (fr) | 1998-03-16 | 1999-03-15 | Xenogreffes osseuses |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1061866A4 (fr) |
JP (1) | JP2002506677A (fr) |
AU (1) | AU755316B2 (fr) |
CA (1) | CA2323866A1 (fr) |
WO (1) | WO1999047080A1 (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6231608B1 (en) * | 1995-06-07 | 2001-05-15 | Crosscart, Inc. | Aldehyde and glycosidase-treated soft and bone tissue xenografts |
US6482584B1 (en) | 1998-11-13 | 2002-11-19 | Regeneration Technologies, Inc. | Cyclic implant perfusion cleaning and passivation process |
US6652818B1 (en) | 1998-11-13 | 2003-11-25 | Regeneration Technologies, Inc. | Implant sterilization apparatus |
US6613278B1 (en) | 1998-11-13 | 2003-09-02 | Regeneration Technologies, Inc. | Tissue pooling process |
US20030039678A1 (en) * | 1998-03-16 | 2003-02-27 | Stone Kevin R. | Xenograft bone matrix for orthopedic applications |
DE69937552T2 (de) * | 1998-04-02 | 2008-09-25 | Crosscart Inc., San Francisco | Knochenxenottransplantate |
US20030068815A1 (en) * | 1999-02-11 | 2003-04-10 | Stone Kevin R. | Sterilized xenograft tissue |
JP4444918B2 (ja) * | 2003-05-15 | 2010-03-31 | 学校法人早稲田大学 | 脱細胞化方法及び生体組織処理装置 |
CN104721883A (zh) | 2004-03-17 | 2015-06-24 | 雷维维科公司 | 来源于缺乏任何功能性α1,3半乳糖基转移酶表达的动物的组织产品 |
US7648676B2 (en) | 2004-04-20 | 2010-01-19 | Rti Biologics, Inc. | Process and apparatus for treating implants comprising soft tissue |
DE102004036881A1 (de) * | 2004-07-22 | 2006-02-16 | Ossacur Ag | Bioresorbierbares Material zur Füllung von Knochendefekten |
DE102004036882A1 (de) * | 2004-07-22 | 2006-02-16 | Ossacur Ag | Bioresorbierbares Material zur Füllung von Knochendefekten |
US8367384B2 (en) | 2005-12-14 | 2013-02-05 | The Invention Science Fund I, Llc | Bone semi-permeable device |
US9005944B2 (en) | 2005-12-14 | 2015-04-14 | The Invention Science Fund I, Llc | Bone cell delivery device |
US8278094B2 (en) | 2005-12-14 | 2012-10-02 | The Invention Science Fund I, Llc | Bone semi-permeable device |
US8354258B2 (en) | 2005-12-14 | 2013-01-15 | The Invention Science Fund I, Llc | Diatom device |
US8198080B2 (en) | 2005-12-14 | 2012-06-12 | The Invention Science Fund I, Llc | Bone delivery device |
US8900865B2 (en) | 2005-12-14 | 2014-12-02 | The Invention Science Fund I, Llc | Blood brain barrier device |
US9061075B2 (en) | 2005-12-14 | 2015-06-23 | The Invention Science Fund I, Llc | Bone delivery device |
US20100191346A1 (en) * | 2007-04-16 | 2010-07-29 | Stephen Bloor | Bone implant |
US8551749B2 (en) | 2009-04-23 | 2013-10-08 | The Invention Science Fund I, Llc | Device including bone cage and method for treatment of disease in a subject |
WO2013096249A1 (fr) | 2011-12-20 | 2013-06-27 | Lifecell Corporation | Produits de tissu en feuille |
CA2859657C (fr) | 2011-12-20 | 2021-03-02 | Lifecell Corporation | Particules de matrice tissulaire acellulaire et produits fluides qui lescomposent |
EP2806907B1 (fr) | 2012-01-24 | 2018-11-21 | LifeCell Corporation | Matrices tissulaires allongées |
TR202009080A2 (tr) | 2020-06-11 | 2021-12-21 | Univ Yildiz Teknik | Hayvan kemiğinden ksenogreft üretimi. |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4400833A (en) | 1981-06-10 | 1983-08-30 | Kurland Kenneth Z | Means and method of implanting bioprosthetics |
SE446372B (sv) | 1983-02-03 | 1986-09-08 | Medinvent Sa | Blodkerlsprotes for anvendning som shunt mellan blodkerl |
US4678470A (en) * | 1985-05-29 | 1987-07-07 | American Hospital Supply Corporation | Bone-grafting material |
US4755593A (en) | 1985-07-24 | 1988-07-05 | Lauren Mark D | Novel biomaterial of cross-linked peritoneal tissue |
US4885585A (en) | 1986-12-23 | 1989-12-05 | Analog Devices, Inc. | Ramp generator reset circuit |
US5071741A (en) | 1988-04-18 | 1991-12-10 | Cryolife, Inc. | Cryoprotective agent and its use in cryopreservation of cellular matter |
US5171660A (en) | 1989-04-26 | 1992-12-15 | Cryolife, Inc. | Process of revitalizing cells and tissue prior to cryopreservation |
US5131850A (en) | 1989-11-03 | 1992-07-21 | Cryolife, Inc. | Method for cryopreserving musculoskeletal tissues |
US5192312A (en) * | 1991-03-05 | 1993-03-09 | Colorado State University Research Foundation | Treated tissue for implantation and methods of treatment and use |
US5160313A (en) | 1991-05-14 | 1992-11-03 | Cryolife, Inc. | Process for preparing tissue for transplantation |
US5333626A (en) * | 1991-12-31 | 1994-08-02 | Cryolife, Inc. | Preparation of bone for transplantation |
US5314476A (en) * | 1992-02-04 | 1994-05-24 | Osteotech, Inc. | Demineralized bone particles and flowable osteogenic composition containing same |
US5411504A (en) * | 1993-08-02 | 1995-05-02 | Vilas; John W. | Drill jig for animal prosthesis insertion |
US5516532A (en) * | 1994-08-05 | 1996-05-14 | Children's Medical Center Corporation | Injectable non-immunogenic cartilage and bone preparation |
IT1268641B1 (it) * | 1994-10-24 | 1997-03-06 | Giuseppe Oliva | Inattivazione ed eliminazione di matrice organica da osso animale per xenotrapianti eterotopici. |
AU759086B2 (en) * | 1998-03-06 | 2003-04-03 | Crosscart, Inc. | Soft tissue xenografts |
-
1999
- 1999-03-15 WO PCT/US1999/005661 patent/WO1999047080A1/fr active Search and Examination
- 1999-03-15 AU AU31868/99A patent/AU755316B2/en not_active Ceased
- 1999-03-15 CA CA002323866A patent/CA2323866A1/fr not_active Abandoned
- 1999-03-15 EP EP99913897A patent/EP1061866A4/fr not_active Withdrawn
- 1999-03-15 JP JP2000536323A patent/JP2002506677A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU3186899A (en) | 1999-10-11 |
WO1999047080A1 (fr) | 1999-09-23 |
JP2002506677A (ja) | 2002-03-05 |
EP1061866A4 (fr) | 2003-07-16 |
AU755316B2 (en) | 2002-12-12 |
EP1061866A1 (fr) | 2000-12-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |