CA2318434A1 - Chimeres et conjugues polypeptidiques thrombogenes presentant une activite dependant de l'association avec l'endothelium vasculaire tumoral - Google Patents
Chimeres et conjugues polypeptidiques thrombogenes presentant une activite dependant de l'association avec l'endothelium vasculaire tumoral Download PDFInfo
- Publication number
- CA2318434A1 CA2318434A1 CA002318434A CA2318434A CA2318434A1 CA 2318434 A1 CA2318434 A1 CA 2318434A1 CA 002318434 A CA002318434 A CA 002318434A CA 2318434 A CA2318434 A CA 2318434A CA 2318434 A1 CA2318434 A1 CA 2318434A1
- Authority
- CA
- Canada
- Prior art keywords
- context
- functional entity
- dependent functional
- substructure
- thr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne des polypeptides et des conjugués chimères initiateurs de thrombsose, un exemple de ces polypeptides et conjugués étant donné dans la Figure 1. L'invention concerne également des compositions renfermant ces polypeptides et ces conjugués, et des produits de recombinaison d'acide nucléique codant ces derniers. Au moins un constituant d'une chimère ou d'un conjugué est spécifique à une ou plusieurs caractéristiques externes de l'endothélium vasculaire des vaisseaux entretenant une tumeur, et au moins un constituant thrombosant est sensiblement inactif si non associé à cet endothélium vasculaire tumoral, ce qui permet une destruction ciblée des tumeurs solides chez un animal.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99674497A | 1997-12-23 | 1997-12-23 | |
US08/996,744 | 1997-12-23 | ||
PCT/US1998/027498 WO1999032143A1 (fr) | 1997-12-23 | 1998-12-22 | Chimeres et conjugues polypeptidiques thrombogenes presentant une activite dependant de l'association avec l'endothelium vasculaire tumoral |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2318434A1 true CA2318434A1 (fr) | 1999-07-01 |
Family
ID=25543254
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002318434A Abandoned CA2318434A1 (fr) | 1997-12-23 | 1998-12-22 | Chimeres et conjugues polypeptidiques thrombogenes presentant une activite dependant de l'association avec l'endothelium vasculaire tumoral |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1041999A1 (fr) |
AU (1) | AU2094199A (fr) |
CA (1) | CA2318434A1 (fr) |
WO (1) | WO1999032143A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6576610B1 (en) | 1999-10-04 | 2003-06-10 | Nuvas, Llc | Use of a context-dependent functional entity to enhance the efficacy of an agent |
DE60115422T2 (de) * | 2000-05-10 | 2006-08-17 | Novo Nordisk Health Care Ag | PHARMAZEUTISCHE ZUSAMMENSETZUNG ENTHALTEND EINEN FAKTOR VIIa UND EINEN TFPI-INHIBITOR |
WO2002020813A2 (fr) | 2000-09-05 | 2002-03-14 | Karolinska Innovations Ab | Materiaux et procedes concernant des inhibiteurs de croissance cellulaire endotheliale |
EP1443954B1 (fr) * | 2001-10-26 | 2010-11-24 | The Scripps Research Institute | Thrombose cible par de polypeptides du facteur tissulaire |
US7393833B2 (en) * | 2005-03-09 | 2008-07-01 | The Board Of Regents Of The University Of Oklahoma | Chimeric proteins with phosphatidylserine binding domains |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5433955A (en) * | 1989-01-23 | 1995-07-18 | Akzo N.V. | Site specific in vivo activation of therapeutic drugs |
US5877289A (en) * | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
-
1998
- 1998-12-22 CA CA002318434A patent/CA2318434A1/fr not_active Abandoned
- 1998-12-22 EP EP98965484A patent/EP1041999A1/fr not_active Withdrawn
- 1998-12-22 AU AU20941/99A patent/AU2094199A/en not_active Abandoned
- 1998-12-22 WO PCT/US1998/027498 patent/WO1999032143A1/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1999032143A1 (fr) | 1999-07-01 |
EP1041999A1 (fr) | 2000-10-11 |
AU2094199A (en) | 1999-07-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |