CA2315033A1 - Oral prophalaxis paste - Google Patents
Oral prophalaxis paste Download PDFInfo
- Publication number
- CA2315033A1 CA2315033A1 CA002315033A CA2315033A CA2315033A1 CA 2315033 A1 CA2315033 A1 CA 2315033A1 CA 002315033 A CA002315033 A CA 002315033A CA 2315033 A CA2315033 A CA 2315033A CA 2315033 A1 CA2315033 A1 CA 2315033A1
- Authority
- CA
- Canada
- Prior art keywords
- paste
- dental
- pumice
- weight
- percent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
An oral prophalaxis paste includes a preselected grade and amount of abrasive material such as pumice clay or diatomaceous earth. The abrasive material is moistened with water and a moisture retention agent such as glycerin is included. A curing system is employed, such as using sodium silicate and methyl salicylate. The formulation provides antimicrobial properties by the inclusion of triclosan.
Description
-. WO 99130677 - -. PCTIUS98/26637 ORAL PROPHALAXIS PASTE
BACKGROUND OF THE INVENTION
Oral compositions containing triclosan are known.
For example, in U.S. Patent 5,472,685, there is described an oral composition which includes an effective antiplaque proportion of triclosan in an oral composition. That composition is in the form of a tooth paste, gel dentrifrice, tooth powder, mouth rinse, mouth wash, tooth hardener, anticalculus composition, gum or lozenge. Such triclosan-containing compositions are known to exhibit an antibacterial effect in the oral cavity.
It has been found that the dentrifrice compositions heretofore known in the art are not useful as oral prophylaxis pastes (also referred to as "prophy" pastes). A main drawback has been that the prior dentrifrices contain low abrasive materials.
This is because such dentrifrices are intended to be used on a daily basis. Therefore, prior to the present invention, there has not been a prophylaxis paste which exhibits antimicrobial properties and which is abrasive enough to be employed by the dental practitioner as a prophalaxis paste.
Therefore, a need exhibits for a prophy paste with acceptable abrasive qualities as well as antimicrobial qualities. The present invention, as will be discussed below meets this need.
DISCLOSURE OF THE INVENTION
It is therefore, an object of the invention to provide an oral prophylaxis paste.
It is another object of the invention to provide a prophylaxis paste with useful abrasive qualities.
It is a further object of the invention to provide such a prophylaxis paste which also exhibits antimicrobial properties.
These and other objects of the invention which will become apparent from the description to follow are accomplished by the invention as hereinafter described and claimed.
In general, a prophylaxis paste comprises a preselected amount and grade of pumice, clay, glycerin and an amount of triclosan.
BACKGROUND OF THE INVENTION
Oral compositions containing triclosan are known.
For example, in U.S. Patent 5,472,685, there is described an oral composition which includes an effective antiplaque proportion of triclosan in an oral composition. That composition is in the form of a tooth paste, gel dentrifrice, tooth powder, mouth rinse, mouth wash, tooth hardener, anticalculus composition, gum or lozenge. Such triclosan-containing compositions are known to exhibit an antibacterial effect in the oral cavity.
It has been found that the dentrifrice compositions heretofore known in the art are not useful as oral prophylaxis pastes (also referred to as "prophy" pastes). A main drawback has been that the prior dentrifrices contain low abrasive materials.
This is because such dentrifrices are intended to be used on a daily basis. Therefore, prior to the present invention, there has not been a prophylaxis paste which exhibits antimicrobial properties and which is abrasive enough to be employed by the dental practitioner as a prophalaxis paste.
Therefore, a need exhibits for a prophy paste with acceptable abrasive qualities as well as antimicrobial qualities. The present invention, as will be discussed below meets this need.
DISCLOSURE OF THE INVENTION
It is therefore, an object of the invention to provide an oral prophylaxis paste.
It is another object of the invention to provide a prophylaxis paste with useful abrasive qualities.
It is a further object of the invention to provide such a prophylaxis paste which also exhibits antimicrobial properties.
These and other objects of the invention which will become apparent from the description to follow are accomplished by the invention as hereinafter described and claimed.
In general, a prophylaxis paste comprises a preselected amount and grade of pumice, clay, glycerin and an amount of triclosan.
WO 99/30677 PCT/US98n6637 PREFERRED EMBODIMENTS FOR CARRYING OUT THE INVENTION
The dental prophalaxis paste composition according to the invention is based upon a moistened pumice baseor clay base, normally containing an amount of pumice or clay, water and preferably a moisture retention agent in the form of glycerin.
The novel paste has a pumice base or clay base moistened to a pasty state. The exact amount of moisture added may be varied within reasonable limits because changing the moisture content in small amounts, although altering the paste consistency does not materially alter the characteristics which depend on the addition of further components. It has been found that the moisture retention agent may also be varied within reasonable amounts because its presence within a limited range does not significantly alter the desired flowing and non-splattering characteristics desired in the paste.
It is preferred to add glycerin and water to the pumice base in a weight amount ratio of about 16:8:4 of pumice or clay, glycerin and water. However, as indicated, the glycerin may readily range from about 6-9 parts to 16 parts of pumice, while the water can vary between about 4 to 6 parts per 16 parts of base without significantly altering the characteristics of the paste.
It will be readily understood that various substitutes fox the preferred glycerin as the moisture retention agent could conceivably be made. Glycerin has been found to work effectively without detracting from the desired final qualities of the paste.
It is envisioned that a prophalaxis paste according to the present invention will be prepared as a fine, medium or coarse grit compound. These designations are relative, and are not necessarily intended to convey exact grades or grit levels.
However, preferred explary compositions will be discussed below. The pumice or clay grade used in each of the different grit pastes is based upon the average particle size of the respective pumice. The table given below provides a grade designation and the average particle size in mesh, inches and microns.
The dental prophalaxis paste composition according to the invention is based upon a moistened pumice baseor clay base, normally containing an amount of pumice or clay, water and preferably a moisture retention agent in the form of glycerin.
The novel paste has a pumice base or clay base moistened to a pasty state. The exact amount of moisture added may be varied within reasonable limits because changing the moisture content in small amounts, although altering the paste consistency does not materially alter the characteristics which depend on the addition of further components. It has been found that the moisture retention agent may also be varied within reasonable amounts because its presence within a limited range does not significantly alter the desired flowing and non-splattering characteristics desired in the paste.
It is preferred to add glycerin and water to the pumice base in a weight amount ratio of about 16:8:4 of pumice or clay, glycerin and water. However, as indicated, the glycerin may readily range from about 6-9 parts to 16 parts of pumice, while the water can vary between about 4 to 6 parts per 16 parts of base without significantly altering the characteristics of the paste.
It will be readily understood that various substitutes fox the preferred glycerin as the moisture retention agent could conceivably be made. Glycerin has been found to work effectively without detracting from the desired final qualities of the paste.
It is envisioned that a prophalaxis paste according to the present invention will be prepared as a fine, medium or coarse grit compound. These designations are relative, and are not necessarily intended to convey exact grades or grit levels.
However, preferred explary compositions will be discussed below. The pumice or clay grade used in each of the different grit pastes is based upon the average particle size of the respective pumice. The table given below provides a grade designation and the average particle size in mesh, inches and microns.
PUMICE CLASSIFICATTONS
PUMICE GRADE MESH SPEC INCH, MM UM
4F 170 100% T .0035,.090 90 200 99% T .0029,.075 75 325 85% T .0017,.045 45 3F 170 <1% R .0035,.090 90 200 <8% R .0029,.075 75 2F 140 <2% R .0041,.106 106 170 <9% R .0035,.090 90 200 80-99%T .0029,.075 75 1F 100 <1% R .0059,.150 150 120 <7% R .0049,.125 125 200 60-90%T .0029,.075 75 0 80 <2% R .0070,.180 180 100 <10% R .0059,.150 150 200 40-80%T .0029,.075 75 NOTE 1: T=Passes through the sieve, R=Remains on sieve A fine grit prophalaxis paste according to the invention will include about 40-50 percent by weight of pumice grade 4F. A medium grit paste will include from about 10-15% of pumice grade 3F and 35-40% of grade 2F.
A coarse grit composition will contain for example, 35 40% by weight of pumice grade 2F and 10-15% of pumice grade O. It is envisioned that other composition containing different grit levels are within the scope of the present invention. For example, a more coarse composition might include 35-40% of pumice grade 1F and 10-15% by weight of pumice grade O. Again, other WO 99/30677 PCTIUS98IZ6b37 amounts of pumice or combinations of pumice may fall within a given designation, without varying from the scope of the present invention. Again, the designations fine, medium and coarse are relative and subjective.
With this understanding, fine, medium and coarse grit level compositions according to the invention may contain the following components.
Grit Levels l~cr~~dient Name (%w/ w)Fine Medium Coarse Purified Water QS QS QS
Pumice 2F -- 36.60 37.57 Pumice 3F -- 12.60 --Pumice 4F 45.20 -- --Pumice O -- -- 12.94 Dacalite 4.00 -- --Glycerin 29.80 30.77 30.06 Polyethylene Glycol 400 1.00 1.00 1.00 Triclosan 0.3-1.0 0.3-1.0 0.3-1.0 Sodium Fluoride 2.70 2.70 2.70 Sodium Silicate 2.86 2.86 2.63 Monosodium Phosphate 0.15 0.15 0.16 Methyl Salicylate 0.85 0.85 0.81 Sodium Saccharin 0.04 0.04 0.04 Sodium Carboxymethylcellulose0.05 0.05 0.05 Colorant Solution 0.15 0.15 0.10 Flavor 0.82 0.83 0'81 TOTAL, % 100.00 100.00 100.00 Alternative compositions within the scope of the invention are provided in Table 2.
Ingredient Name f%w/w)Fine Medium Coarse Purified Water 13.237 11.222 10.948 Pumice 45.20 49.21 50.51 Glycerin 28.70 30.77 30.00 Distomacsous Earth 4.00 -- --Sodium Fluoride 2.78 2.70 2.73 Sodium Silicate 2.86 2.86 2.63 Polyethylene Glycol 400 1.00 1.00 1.00 Methyl Sallcylate 0.85 0.85 0.81 Flavorant 0.82 0.83 0.81 Triclasan 0.82 0.83 0.81 Sodium Phosphate 0.15 0.16 Monobasic 0.15 Monosodium Phosphate0.15 0.15 0.16 Sodium Saccharin 0.04 0.04 0.04 Sodium CarboxymethylCellulose 0.05 0.05 0.05 FD&C Blue #1 --- 0.009 ---FD&C Blue #2 --- 0.009 ---FD&C Blue #6 0.013 --- ---FD&C Blue #40 --- -- 0.012 TOTAL, ~ 100.00 100.00 100.00 To the pumice paste, containing pumice, glycerin and water, as discussed above, is added the sodium silicate, methyl salicylate and sodium carboxymethycellulose. The sodium silicate and methyl salicylate together form the curing system of the composition in the ratios of sodium silicate (3-4 parts) to methyl salicylate (0.25-1.25 parts). The sodium carboxymethylcellulose acts as a gum. Other materials may be included as a gum such as agar agar or the like. It has been found that these materials, when WO 99/30677 PCT/US98l26637 employed in the paste, act synergistically to create unique flow characteristics in the paste. By blending an amount of a gum system, such as sodium carboxymethylcellulose, and a small amount of the curing system, that is up to about 2% by weight of the gum system and up to about 10% by weight of the cure system, the material will flow smoothly under pressure, without segregation or settling of the pumice.
Dacalite is also a useful grit material, as is diatomaceous earth. The polyethylene glycol is also a moisture retaining agent;. sodium fluoride is known to be used as an anticarries agent; monosodium phosphate is a buffer; and sodium saccharin is added as a sweetener. Colorant solutions and flavoring agents are optional as are the sweetener and the sodium fluoride.
An example of the prophalaxis paste without the triclosan is provided in U.S. Patent 3,228,845, which is hereby incorporated by reference for such disclosure. It has been found that the addition of the antimicrobial agent of triclosan in an amount of from 0.2 to about 1.2 percent by weight provides a dental prophalaxis paste with desirable antimicrobial properties.
The prophalaxis paste according to the present invention have abrasion values above those of the dentrifices currently known commercially. The abrasive ratings table provided below gives an example of the inventive prophy pastes and their relative dental abrasion (RDA) values as compared to commercially available dentrifrices.
products Dentin Abrasion (RDA) Values Inventive Paste Fine Grit 704 Inventive Paste Medium Grit 256 Inventive Paste Coarse Grit 362 Crest Regular Toothpaste 81 Crest Tartar Control Toothpaste 126 Colgate Tartar Control Toothpaste 112 Aim Tartar Control Toothpaste 127 Aquafresh Tartar Control Toothpaste 125 Close-up Tartar Control Toothpaste 120 The RDA value as used in the present description, may be determined by any of the standard methods including the Grabensteder method or the Hefferen method. The Hefferen method is preferred because it is recognized by the American Dental Association. While the RDA is the method for evaluation the abrasive nature of normally, toothpaste, another method known as the relative enamel abrasion (REA) is normally used for evaluating prophy paste. There is no specific correlation between the recognized RDA and REA test methods. According to the present invention, a prophy paste having a REA value of preferably above about 3 is within the scope of the invention.
GENERAL EXPERIMENTAL
In order to demonstrate the effectiveness of the present invention in carrying out the objects as set forth above, a number of formulations were prepared according to the present invention. Medium, fine and coarse grit formulations were prepared. Samples 1 and 2 contain medium grit pumice and 0.3% and 1.0%
triclosan respectively. Sample 3 is a medium grit prophy paste available from DENTSPLY International Inc.
As NUPRO. Samples 4 and 5 contain fine grit and 0.3%
and 1.0% triclosan respectively. Sample 6 is a fine grit NUPRO prophy paste. Samples 7 and 8 are a coarse grit, 0.3% and 1.0% triclosan respectively formulation.
Sample 9 is a coarse grit NUPRO prophy paste. The NUPRO prophy paste as used in these experiments are commercially available.
PROCEDURE
Culture Preparation: Klebsiella pneumoniae and Streptococcus mutans were used in the assay. The cultures were maintained lyophilized prior to use.
Klebsiella pnumoniae was grown on soybean casein digest agar (LMRS) at 37 ~ 2°C for 18-24 hours. Streptococcus was grown on soybean casein digest agar with 5% blood (BAP) at 37 t 2°C for 48-72 hours . The cultures were harvested in 0.9% saline to the approximate turbidity of a 0.5 McFarland standard.
Test Performance: The Klebsiella suspension was added to Mueller Hinton agar and the Streptococcus suspension was added to BAP with sterile cotton swabs using a three direction sweep (Kirby-Bauer method).
Six plates were prepared for each organism.
The products were added to sterile 1/4 inch filter paper discs using 10 mg per disc. Twelve discs were prepared for each product.
The discs were added to the inoculated plates.
One disc containing each product on each plate. The Klebsiella plates were incubated at 37 ~ 2°C for 18-24 hours. The Streptococcus plates were incubated at 37 t 2°C for 48 hours. The diameters of the zones of inhibition were then measured for each product using a caliper.
RESULTS:
Table 2 contains the results for the products against Klebsiella pneumoniae. Table 3 contains the results for the products against Streptococcus mutans.
The tables also contain the average diameter of the zones of inhibition for each product against each organisms. The average zone of inhibition was calculated from six replicates. The products with a 0 mm zone diameter demonstrated inhibition directly under the sample only (no diffusion of antimicrobial activity).
The sample that showed the largest zone of inhibition against Klebsiella pneumoniae was Sample 5.
The sample that showed the largest zone of inhibition against Streptoccocus mutans was Sample 8.
WO 99/30677 PCT/US98n6637 Sample ID Average Zone Diameter 1 37.6 mm 2 40.0 mm 3 0 mm 4 38.6 mm 41.6 mm 6 0 mm 7 36.5 mm 8 38.5 mm 9 0 mm Sample ID Average Zone Diameter 1 10.1 mm 2 10.9 mm 3 0 mm 4 10.1 mm 5 11.1 mm 6 0 mm 7 9.6 mm 8 12.8 mm 9 0 mm Therefore, it is apparent that a prophalaxis paste according to the invention as described above, is useful in meeting the stated objectives of the invention. It will be understood that amount of various components, can be varied and still fall within the scope of the invention. Similarly, specific formulation components as provided above are merely explary, and other components similar or otherwise are also within the scope of the invention. The scope of the invention will be determined only by the claims.
PUMICE GRADE MESH SPEC INCH, MM UM
4F 170 100% T .0035,.090 90 200 99% T .0029,.075 75 325 85% T .0017,.045 45 3F 170 <1% R .0035,.090 90 200 <8% R .0029,.075 75 2F 140 <2% R .0041,.106 106 170 <9% R .0035,.090 90 200 80-99%T .0029,.075 75 1F 100 <1% R .0059,.150 150 120 <7% R .0049,.125 125 200 60-90%T .0029,.075 75 0 80 <2% R .0070,.180 180 100 <10% R .0059,.150 150 200 40-80%T .0029,.075 75 NOTE 1: T=Passes through the sieve, R=Remains on sieve A fine grit prophalaxis paste according to the invention will include about 40-50 percent by weight of pumice grade 4F. A medium grit paste will include from about 10-15% of pumice grade 3F and 35-40% of grade 2F.
A coarse grit composition will contain for example, 35 40% by weight of pumice grade 2F and 10-15% of pumice grade O. It is envisioned that other composition containing different grit levels are within the scope of the present invention. For example, a more coarse composition might include 35-40% of pumice grade 1F and 10-15% by weight of pumice grade O. Again, other WO 99/30677 PCTIUS98IZ6b37 amounts of pumice or combinations of pumice may fall within a given designation, without varying from the scope of the present invention. Again, the designations fine, medium and coarse are relative and subjective.
With this understanding, fine, medium and coarse grit level compositions according to the invention may contain the following components.
Grit Levels l~cr~~dient Name (%w/ w)Fine Medium Coarse Purified Water QS QS QS
Pumice 2F -- 36.60 37.57 Pumice 3F -- 12.60 --Pumice 4F 45.20 -- --Pumice O -- -- 12.94 Dacalite 4.00 -- --Glycerin 29.80 30.77 30.06 Polyethylene Glycol 400 1.00 1.00 1.00 Triclosan 0.3-1.0 0.3-1.0 0.3-1.0 Sodium Fluoride 2.70 2.70 2.70 Sodium Silicate 2.86 2.86 2.63 Monosodium Phosphate 0.15 0.15 0.16 Methyl Salicylate 0.85 0.85 0.81 Sodium Saccharin 0.04 0.04 0.04 Sodium Carboxymethylcellulose0.05 0.05 0.05 Colorant Solution 0.15 0.15 0.10 Flavor 0.82 0.83 0'81 TOTAL, % 100.00 100.00 100.00 Alternative compositions within the scope of the invention are provided in Table 2.
Ingredient Name f%w/w)Fine Medium Coarse Purified Water 13.237 11.222 10.948 Pumice 45.20 49.21 50.51 Glycerin 28.70 30.77 30.00 Distomacsous Earth 4.00 -- --Sodium Fluoride 2.78 2.70 2.73 Sodium Silicate 2.86 2.86 2.63 Polyethylene Glycol 400 1.00 1.00 1.00 Methyl Sallcylate 0.85 0.85 0.81 Flavorant 0.82 0.83 0.81 Triclasan 0.82 0.83 0.81 Sodium Phosphate 0.15 0.16 Monobasic 0.15 Monosodium Phosphate0.15 0.15 0.16 Sodium Saccharin 0.04 0.04 0.04 Sodium CarboxymethylCellulose 0.05 0.05 0.05 FD&C Blue #1 --- 0.009 ---FD&C Blue #2 --- 0.009 ---FD&C Blue #6 0.013 --- ---FD&C Blue #40 --- -- 0.012 TOTAL, ~ 100.00 100.00 100.00 To the pumice paste, containing pumice, glycerin and water, as discussed above, is added the sodium silicate, methyl salicylate and sodium carboxymethycellulose. The sodium silicate and methyl salicylate together form the curing system of the composition in the ratios of sodium silicate (3-4 parts) to methyl salicylate (0.25-1.25 parts). The sodium carboxymethylcellulose acts as a gum. Other materials may be included as a gum such as agar agar or the like. It has been found that these materials, when WO 99/30677 PCT/US98l26637 employed in the paste, act synergistically to create unique flow characteristics in the paste. By blending an amount of a gum system, such as sodium carboxymethylcellulose, and a small amount of the curing system, that is up to about 2% by weight of the gum system and up to about 10% by weight of the cure system, the material will flow smoothly under pressure, without segregation or settling of the pumice.
Dacalite is also a useful grit material, as is diatomaceous earth. The polyethylene glycol is also a moisture retaining agent;. sodium fluoride is known to be used as an anticarries agent; monosodium phosphate is a buffer; and sodium saccharin is added as a sweetener. Colorant solutions and flavoring agents are optional as are the sweetener and the sodium fluoride.
An example of the prophalaxis paste without the triclosan is provided in U.S. Patent 3,228,845, which is hereby incorporated by reference for such disclosure. It has been found that the addition of the antimicrobial agent of triclosan in an amount of from 0.2 to about 1.2 percent by weight provides a dental prophalaxis paste with desirable antimicrobial properties.
The prophalaxis paste according to the present invention have abrasion values above those of the dentrifices currently known commercially. The abrasive ratings table provided below gives an example of the inventive prophy pastes and their relative dental abrasion (RDA) values as compared to commercially available dentrifrices.
products Dentin Abrasion (RDA) Values Inventive Paste Fine Grit 704 Inventive Paste Medium Grit 256 Inventive Paste Coarse Grit 362 Crest Regular Toothpaste 81 Crest Tartar Control Toothpaste 126 Colgate Tartar Control Toothpaste 112 Aim Tartar Control Toothpaste 127 Aquafresh Tartar Control Toothpaste 125 Close-up Tartar Control Toothpaste 120 The RDA value as used in the present description, may be determined by any of the standard methods including the Grabensteder method or the Hefferen method. The Hefferen method is preferred because it is recognized by the American Dental Association. While the RDA is the method for evaluation the abrasive nature of normally, toothpaste, another method known as the relative enamel abrasion (REA) is normally used for evaluating prophy paste. There is no specific correlation between the recognized RDA and REA test methods. According to the present invention, a prophy paste having a REA value of preferably above about 3 is within the scope of the invention.
GENERAL EXPERIMENTAL
In order to demonstrate the effectiveness of the present invention in carrying out the objects as set forth above, a number of formulations were prepared according to the present invention. Medium, fine and coarse grit formulations were prepared. Samples 1 and 2 contain medium grit pumice and 0.3% and 1.0%
triclosan respectively. Sample 3 is a medium grit prophy paste available from DENTSPLY International Inc.
As NUPRO. Samples 4 and 5 contain fine grit and 0.3%
and 1.0% triclosan respectively. Sample 6 is a fine grit NUPRO prophy paste. Samples 7 and 8 are a coarse grit, 0.3% and 1.0% triclosan respectively formulation.
Sample 9 is a coarse grit NUPRO prophy paste. The NUPRO prophy paste as used in these experiments are commercially available.
PROCEDURE
Culture Preparation: Klebsiella pneumoniae and Streptococcus mutans were used in the assay. The cultures were maintained lyophilized prior to use.
Klebsiella pnumoniae was grown on soybean casein digest agar (LMRS) at 37 ~ 2°C for 18-24 hours. Streptococcus was grown on soybean casein digest agar with 5% blood (BAP) at 37 t 2°C for 48-72 hours . The cultures were harvested in 0.9% saline to the approximate turbidity of a 0.5 McFarland standard.
Test Performance: The Klebsiella suspension was added to Mueller Hinton agar and the Streptococcus suspension was added to BAP with sterile cotton swabs using a three direction sweep (Kirby-Bauer method).
Six plates were prepared for each organism.
The products were added to sterile 1/4 inch filter paper discs using 10 mg per disc. Twelve discs were prepared for each product.
The discs were added to the inoculated plates.
One disc containing each product on each plate. The Klebsiella plates were incubated at 37 ~ 2°C for 18-24 hours. The Streptococcus plates were incubated at 37 t 2°C for 48 hours. The diameters of the zones of inhibition were then measured for each product using a caliper.
RESULTS:
Table 2 contains the results for the products against Klebsiella pneumoniae. Table 3 contains the results for the products against Streptococcus mutans.
The tables also contain the average diameter of the zones of inhibition for each product against each organisms. The average zone of inhibition was calculated from six replicates. The products with a 0 mm zone diameter demonstrated inhibition directly under the sample only (no diffusion of antimicrobial activity).
The sample that showed the largest zone of inhibition against Klebsiella pneumoniae was Sample 5.
The sample that showed the largest zone of inhibition against Streptoccocus mutans was Sample 8.
WO 99/30677 PCT/US98n6637 Sample ID Average Zone Diameter 1 37.6 mm 2 40.0 mm 3 0 mm 4 38.6 mm 41.6 mm 6 0 mm 7 36.5 mm 8 38.5 mm 9 0 mm Sample ID Average Zone Diameter 1 10.1 mm 2 10.9 mm 3 0 mm 4 10.1 mm 5 11.1 mm 6 0 mm 7 9.6 mm 8 12.8 mm 9 0 mm Therefore, it is apparent that a prophalaxis paste according to the invention as described above, is useful in meeting the stated objectives of the invention. It will be understood that amount of various components, can be varied and still fall within the scope of the invention. Similarly, specific formulation components as provided above are merely explary, and other components similar or otherwise are also within the scope of the invention. The scope of the invention will be determined only by the claims.
Claims (11)
1. A dental prophylactic paste comprising a composition having a paste component and an antimicrobial component, wherein the prophylactic paste has a relative dental abrasion value of above about 200.
2. A dental prophylactic paste as in claim 1, wherein said antimicrobial component comprises 2,2,4'-trichloro-2'-hydroxydiphenyl ether.
3. A dental prophylactic paste as in claim 1 wherein said composition comprises from about 99.8 to about 98.8 percent by weight of said paste component and from about 0.2 to about 1.2 percent by weight of said antimicrobial component.
4. A dental prophylactic paste as in claim 3, wherein said paste component comprises a weight ratio of (a) about 16 parts of a dental abrasive selected from the group consisting of pumice, clay and mixtures thereof, to (b) about 6 to about 16 parts of a moisture retention agent, to (c) about 4 to about 6 parts of water.
5. A dental prophylactic paste as in claim 4, wherein said moisture retention agent is glycerin.
6. A dental prophylactic paste as in claim 1, further comprising a cure package.
7. A dental prophylactic paste as in claim 6, wherein said cure package comprises sodium silicate and methyl salicylate.
8. A dental prophylactic paste as in claim 6, further comprising a gum additive.
9. A dental prophylactic paste as in claim 8, wherein said gum additive is selected from the group consisting of agar agar and sodium carboxymethylcellulose.
10. A dental prophylactic paste as in claim 8, wherein 100 percent by weight of said composition comprises about 2 percent by weight of said gum and about 10 percent by weight of said cure package.
11. A dental prophylacic paste as in claim 1, having a relative enamel abrasion value of above about 3.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6969397P | 1997-12-16 | 1997-12-16 | |
| US60/069,693 | 1997-12-16 | ||
| PCT/US1998/026637 WO1999030677A1 (en) | 1997-12-16 | 1998-12-15 | Oral prophalaxis paste |
| US09/212,952 US6280707B1 (en) | 1998-12-15 | 1998-12-15 | Oral prophalaxis paste |
| US09/212,952 | 1998-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2315033A1 true CA2315033A1 (en) | 1999-06-24 |
Family
ID=26750325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002315033A Abandoned CA2315033A1 (en) | 1997-12-16 | 1998-12-15 | Oral prophalaxis paste |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1027030A1 (en) |
| JP (1) | JP2002511389A (en) |
| AU (1) | AU1727099A (en) |
| CA (1) | CA2315033A1 (en) |
| WO (1) | WO1999030677A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100361321B1 (en) * | 2000-06-17 | 2002-11-18 | 주식회사 태평양 | A method for preparing oral composition containing triclosan and it's oral composition prepared by the same |
| EP2100642A1 (en) | 2008-03-13 | 2009-09-16 | 3M Innovative Properties Company | Composition containing a water-miscible liquid and water-soluble particles, method of production and use thereof |
| CA2764331C (en) * | 2009-06-03 | 2018-07-17 | Ex-Tek, Llc | Anti-infective skin treatment compositions |
| BR112017018506B1 (en) * | 2015-03-20 | 2021-06-22 | Gc Corporation | CURABLE DENTAL COMPOSITION AND ITS MANUFACTURING METHOD |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3228845A (en) * | 1963-02-28 | 1966-01-11 | William K Najjar | Dental cleanser paste |
| US4144322A (en) * | 1975-01-28 | 1979-03-13 | Colgate Palmolive Company | Reduction of abrasiveness in dentrifices |
| US4235874A (en) * | 1979-06-11 | 1980-11-25 | Colgate Palmolive Company | Dentifrice |
| GB8411841D0 (en) * | 1984-05-09 | 1984-06-13 | Unilever Plc | Oral compositions |
| US5094843A (en) * | 1990-09-10 | 1992-03-10 | Beecham Inc. | Antimicrobial toothpaste |
| US5605676A (en) * | 1995-06-26 | 1997-02-25 | Colgate-Palmolive Company | Oral composition exhibiting improved uptake and retention of antibacterial compounds on dental tissue surfaces |
-
1998
- 1998-12-15 JP JP2000538661A patent/JP2002511389A/en active Pending
- 1998-12-15 EP EP98962113A patent/EP1027030A1/en not_active Withdrawn
- 1998-12-15 CA CA002315033A patent/CA2315033A1/en not_active Abandoned
- 1998-12-15 AU AU17270/99A patent/AU1727099A/en not_active Abandoned
- 1998-12-15 WO PCT/US1998/026637 patent/WO1999030677A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU1727099A (en) | 1999-07-05 |
| JP2002511389A (en) | 2002-04-16 |
| EP1027030A1 (en) | 2000-08-16 |
| WO1999030677A1 (en) | 1999-06-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI468179B (en) | Oral care regimen | |
| US6280707B1 (en) | Oral prophalaxis paste | |
| EP0934067A1 (en) | Antimicrobial compositions | |
| EP1139993A1 (en) | High water content dentifrice composition and method of making the same | |
| JP2002187809A (en) | Tooth coating agent | |
| CA1322726C (en) | Low abrasion, non-reactive, base formulation toothpaste | |
| US4559223A (en) | Silver sulfadiazine and/or zinc sulfadiazine-containing toothpaste or oral medicament | |
| CA2315033A1 (en) | Oral prophalaxis paste | |
| CN1489452A (en) | Anti-calculus and plaque toothpaste composition | |
| KR100951396B1 (en) | Dental composition for antiplaque and antigingivity | |
| JP2004123684A (en) | Dentifrice composition | |
| JP3336688B2 (en) | Oral composition | |
| JP7167659B2 (en) | dentifrice composition | |
| JP6105261B2 (en) | Oral composition | |
| JP2017114818A (en) | Polymer gel formulation for oral use | |
| JP2738092B2 (en) | Oral composition | |
| WO2018221609A1 (en) | Dentifrice composition | |
| JP7078043B2 (en) | Toothpaste composition | |
| JPH11116453A (en) | Adhesion inhibitor of pathogenic microorganism of periodontal disease | |
| JPH06157258A (en) | Gelatinous dentifrice composition | |
| KR900005069B1 (en) | Tooth paste compositions | |
| WO2022059642A1 (en) | Dentifrice composition | |
| JP2023092382A (en) | Liquid oral composition | |
| KR101583760B1 (en) | Toothpaste composition comprising chondrodite | |
| KR20050023598A (en) | Composition of Toothpaste |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |