CA2308122A1 - Test anticoagulant - Google Patents

Test anticoagulant Download PDF

Info

Publication number
CA2308122A1
CA2308122A1 CA002308122A CA2308122A CA2308122A1 CA 2308122 A1 CA2308122 A1 CA 2308122A1 CA 002308122 A CA002308122 A CA 002308122A CA 2308122 A CA2308122 A CA 2308122A CA 2308122 A1 CA2308122 A1 CA 2308122A1
Authority
CA
Canada
Prior art keywords
iib
monoclonal antibody
iiia
iiia receptor
receptor antagonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002308122A
Other languages
English (en)
Inventor
Bohumil Bednar
Daniel M. Bollag
Robert J. Gould
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806037.9A external-priority patent/GB9806037D0/en
Application filed by Individual filed Critical Individual
Publication of CA2308122A1 publication Critical patent/CA2308122A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70546—Integrin superfamily, e.g. VLAs, leuCAM, GPIIb/GPIIIa, LPAM
    • G01N2333/70557—Integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/222—Platelet disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/224—Haemostasis or coagulation

Abstract

La présente invention concerne une méthode de diagnostic, chez un patient, d'un risque de thrombocytopénie induite par l'administration d'un antagoniste du récepteur de GP IIb/IIIa. Cette méthode consiste à combiner i) un échantillon plasmatique du patient, ii) un anticorps monoclonal détectable, lequel reconnaît des sites de fixation induits, formés sur le récepteur de GP IIb/IIIa, par suite de l'association d'un antagoniste du récepteur du fibrinogène et du récepteur de GP IIb/IIIa, et iii) le complexe antagoniste du récepteur de GP IIb/IIIa/récepteur de GP IIb/III, puis à déterminer l'association de l'anticorps monoclonal détectable avec le complexe, en présence du plasma.
CA002308122A 1997-10-14 1998-10-13 Test anticoagulant Abandoned CA2308122A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6183997P 1997-10-14 1997-10-14
US60/061,839 1997-10-14
GB9806037.9 1998-03-20
GBGB9806037.9A GB9806037D0 (en) 1998-03-20 1998-03-20 Anticoagulant test
PCT/US1998/021596 WO1999019463A1 (fr) 1997-10-14 1998-10-13 Test anticoagulant

Publications (1)

Publication Number Publication Date
CA2308122A1 true CA2308122A1 (fr) 1999-04-22

Family

ID=26313329

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002308122A Abandoned CA2308122A1 (fr) 1997-10-14 1998-10-13 Test anticoagulant

Country Status (4)

Country Link
EP (1) EP1034256A1 (fr)
AU (1) AU1082699A (fr)
CA (1) CA2308122A1 (fr)
WO (1) WO1999019463A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6623981B2 (en) 1998-01-27 2003-09-23 Bristol-Myers Squibb Company Detection of patients at risk for developing integrin antagonist/agonist mediated disease states
US10364288B2 (en) 2013-05-24 2019-07-30 Biogen Ma Inc. Anti-GPIIB/IIIA antibodies or uses thereof
MA40835A (fr) 2014-10-23 2017-08-29 Biogen Ma Inc Anticorps anti-gpiib/iiia et leurs utilisations
MA40861A (fr) * 2014-10-31 2017-09-05 Biogen Ma Inc Anticorps anti-glycoprotéines iib/iiia
CN116482345B (zh) * 2023-06-16 2023-09-22 军科正源（北京）药物研究有限责任公司 用于检测双靶点药物受体占有率的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5114842A (en) * 1987-07-08 1992-05-19 The Scripps Research Institute Peptides and antibodies that inhibit platelet adhesion

Also Published As

Publication number Publication date
EP1034256A1 (fr) 2000-09-13
WO1999019463A1 (fr) 1999-04-22
AU1082699A (en) 1999-05-03

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Legal Events

Date Code Title Description
FZDE Discontinued