CA2307567A1 - Polymer matrix/cell construct for bladder reconstruction - Google Patents
Polymer matrix/cell construct for bladder reconstruction Download PDFInfo
- Publication number
- CA2307567A1 CA2307567A1 CA002307567A CA2307567A CA2307567A1 CA 2307567 A1 CA2307567 A1 CA 2307567A1 CA 002307567 A CA002307567 A CA 002307567A CA 2307567 A CA2307567 A CA 2307567A CA 2307567 A1 CA2307567 A1 CA 2307567A1
- Authority
- CA
- Canada
- Prior art keywords
- area
- cell population
- polymeric matrix
- polymer matrix
- cell construct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011159 matrix material Substances 0.000 title abstract 4
- 229920000642 polymer Polymers 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 210000000056 organ Anatomy 0.000 abstract 2
- 210000001519 tissue Anatomy 0.000 abstract 2
- 230000003416 augmentation Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/042—Urinary bladders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3826—Muscle cells, e.g. smooth muscle cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/383—Nerve cells, e.g. dendritic cells, Schwann cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3882—Hollow organs, e.g. bladder, esophagus, urether, uterus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
- A61L27/3891—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types as distinct cell layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/22—Materials or treatment for tissue regeneration for reconstruction of hollow organs, e.g. bladder, esophagus, urether, uterus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Diaphragms And Bellows (AREA)
- Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
Abstract
The invention is directed to methods and devices for the reconstruction, repair, augmentation or replacement of laminarily organized luminal organs or tissue structures in a patient in need of such treatment.
The device comprises a biocompatible synthetic or natural polymeric matrix shaped to conform to at least a part of the luminal organ or tissue structure with a first cell population on or in a first area and a second cell population such as a smooth muscle cell population in a second area of the polymeric matrix. The method involves grafting the device to an area in a patient in need of treatment. The polymeric matrix comprises a biocompatible and biodegradable material.
The device comprises a biocompatible synthetic or natural polymeric matrix shaped to conform to at least a part of the luminal organ or tissue structure with a first cell population on or in a first area and a second cell population such as a smooth muscle cell population in a second area of the polymeric matrix. The method involves grafting the device to an area in a patient in need of treatment. The polymeric matrix comprises a biocompatible and biodegradable material.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6379097P | 1997-10-31 | 1997-10-31 | |
US60/063,790 | 1997-10-31 | ||
PCT/US1998/022962 WO1999022781A2 (en) | 1997-10-31 | 1998-10-30 | Bladder reconstruction |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2307567A1 true CA2307567A1 (en) | 1999-05-14 |
CA2307567C CA2307567C (en) | 2009-01-20 |
Family
ID=22051510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002307567A Expired - Fee Related CA2307567C (en) | 1997-10-31 | 1998-10-30 | Polymer matrix/cell construct for bladder reconstruction |
Country Status (8)
Country | Link |
---|---|
US (5) | US6576019B1 (en) |
EP (1) | EP1032435B1 (en) |
JP (1) | JP4057781B2 (en) |
AT (1) | ATE248615T1 (en) |
AU (1) | AU747166B2 (en) |
CA (1) | CA2307567C (en) |
DE (1) | DE69817863T2 (en) |
WO (1) | WO1999022781A2 (en) |
Families Citing this family (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020055786A1 (en) * | 1994-08-16 | 2002-05-09 | Anthony Atala | Reconstruction of urological structures with polymeric matrices |
JP4162378B2 (en) | 1997-10-31 | 2008-10-08 | チルドレンズ メディカル センター コーポレーション | Penis reconstruction |
DE69817863T2 (en) | 1997-10-31 | 2004-07-15 | Children's Medical Center Corp., Boston | BLADDER RECONSTRUCTION |
DK1079772T3 (en) * | 1998-05-21 | 2005-06-06 | Childrens Medical Center | Penile Reconstruction Using Swelling Body Tissue |
US6251064B1 (en) * | 1998-12-11 | 2001-06-26 | Enteric Medical Technologies, Inc. | Method for creating valve-like mechanism in natural body passageway |
US6238335B1 (en) * | 1998-12-11 | 2001-05-29 | Enteric Medical Technologies, Inc. | Method for treating gastroesophageal reflux disease and apparatus for use therewith |
US7132582B2 (en) * | 2003-05-30 | 2006-11-07 | Council Of Scientific And Industrial Research | Catalytic process for the preparation of isolongifolene |
US20040167634A1 (en) * | 1999-05-26 | 2004-08-26 | Anthony Atala | Prosthetic kidney and its use for treating kidney disease |
US6428802B1 (en) * | 1999-12-29 | 2002-08-06 | Children's Medical Center Corp. | Preparing artificial organs by forming polylayers of different cell populations on a substrate |
US6368859B1 (en) * | 1999-12-29 | 2002-04-09 | Children's Medical Center Corporation | Methods and compositions for producing a fascial sling |
AT411328B (en) * | 2000-07-12 | 2003-12-29 | Universitaetsklinikum Freiburg | TUBE SYSTEM FOR THE RECONSTRUCTION OF A URINE TUBE |
CA2820144C (en) * | 2001-09-26 | 2017-06-20 | Intrexon Corporation | Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof |
CN1289155C (en) * | 2001-11-16 | 2006-12-13 | 儿童医疗中心有限公司 | Augmentation of organ function |
US7049057B2 (en) * | 2001-11-16 | 2006-05-23 | Children's Medical Center Corporation | Tissue engineered uterus |
US20040047911A1 (en) * | 2002-08-13 | 2004-03-11 | Medtronic, Inc. | Active agent delivery system including a poly(ethylene-co-(meth)Acrylate), medical device, and method |
DE60316579T2 (en) * | 2002-08-13 | 2008-07-03 | Medtronic, Inc., Minneapolis | SYSTEM FOR THE DELIVERY OF ACTIVE SUBSTANCES WITH A HYDROPHOBIC CELLULOSE DERIVATIVE |
DE60333566D1 (en) * | 2002-08-13 | 2010-09-09 | Medtronic Inc | MEDICAL DEVICE WITH IMPROVED LIABILITY BETWEEN A POLYMERIC TOUCH AND A SUBSTRATE |
JP2006502135A (en) * | 2002-08-13 | 2006-01-19 | メドトロニック・インコーポレーテッド | Active drug delivery system, medical device and method |
US8940292B2 (en) | 2003-01-28 | 2015-01-27 | Wake Forest University Health Sciences | Enhancement of angiogenesis to grafts using cells engineered to produce growth factors |
GB0304918D0 (en) * | 2003-03-05 | 2003-04-09 | Celltran Ltd | Cell culture |
JP4598671B2 (en) * | 2003-03-31 | 2010-12-15 | 帝人株式会社 | Manufacturing method of supporting substrate and composite |
JP2008511339A (en) * | 2003-08-13 | 2008-04-17 | メドトロニック・インコーポレーテッド | Active drug delivery system, medical device and method comprising monolayers of compatible polymer blends |
EP1681921A4 (en) * | 2003-10-23 | 2011-08-10 | Univ Georgetown | Method for two- and three-dimensional microassembly of patterns and structures |
US20060199265A1 (en) * | 2005-03-02 | 2006-09-07 | Wolf Michael F | Seeding implantable medical devices with cells |
US7759120B2 (en) | 2005-03-02 | 2010-07-20 | Kps Bay Medical, Inc. | Seeding implantable medical devices with cells |
ITMI20051854A1 (en) * | 2005-10-03 | 2007-04-04 | Sambusseti Antonio | PATCH FOR THE REPLACEMENT OF A VESCICAL WALL PORTION FOLLOWED BY PARTIAL VESCITECTOMY |
JP5416415B2 (en) * | 2006-02-10 | 2014-02-12 | テンジオン, インコーポレイテッド | Skeleton for organ reconstruction and augmentation |
US20070275363A1 (en) * | 2006-02-10 | 2007-11-29 | Bertram Timothy A | Bioreactor for organ reconstruction and augmentation |
EP1905462A1 (en) * | 2006-09-29 | 2008-04-02 | Johnson & Johnson Regenerative Therapeutics, LLC | Hollow tissue growth devices made by lyophilization |
US20080081362A1 (en) * | 2006-09-29 | 2008-04-03 | Daniel Keeley | Multilayered Composite for Organ Augmentation and Repair |
US8658851B2 (en) * | 2006-10-20 | 2014-02-25 | Keracure, Inc. | Devices with cells cultured on flexible supports |
US8728170B1 (en) * | 2006-12-28 | 2014-05-20 | Boston Scientific Scimed, Inc. | Bioerodible nano-fibrous and nano-porous conductive composites |
CN101687063A (en) * | 2007-04-26 | 2010-03-31 | 先进科技及再生医学有限责任公司 | tissue engineering devices and methods for luminal organs |
US9580688B2 (en) | 2007-06-08 | 2017-02-28 | Wake Forest University Health Sciences | Kidney structures and methods of forming the same |
AU2008262333B2 (en) | 2007-06-08 | 2014-07-17 | Wake Forest University Health Sciences | Selective cell therapy for the treatment of renal failure |
US20090036907A1 (en) * | 2007-07-30 | 2009-02-05 | Yves Bayon | Bioresorbable knit |
US8834578B2 (en) * | 2007-07-30 | 2014-09-16 | Sofradim Production | Bioresorbable implant |
US8198087B2 (en) | 2007-07-30 | 2012-06-12 | Sofradim Production Sas | Tissue engineering support |
WO2009025790A1 (en) * | 2007-08-17 | 2009-02-26 | Catalyst Assets Llc | Diagnostic and prognostic use of human bladder cancer-associated micro rnas |
US20090075371A1 (en) * | 2007-09-18 | 2009-03-19 | Daniel Keeley | Regenerative Medicine Devices and Foam Methods of Manufacture |
US9308068B2 (en) | 2007-12-03 | 2016-04-12 | Sofradim Production | Implant for parastomal hernia |
US11051733B2 (en) * | 2008-01-18 | 2021-07-06 | Wake Forest University Health Sciences | Isolating and purifying cells for therapy |
US20090263484A1 (en) * | 2008-04-22 | 2009-10-22 | Hammer Joseph J | Tissue Engineering Devices and Methods for Luminal Organs |
WO2009156866A2 (en) | 2008-06-27 | 2009-12-30 | Sofradim Production | Biosynthetic implant for soft tissue repair |
CN107988072B (en) * | 2008-07-16 | 2022-11-29 | 儿童医疗中心有限公司 | Organ mimic device with microchannels and methods of use and manufacture thereof |
US9492593B2 (en) | 2008-09-24 | 2016-11-15 | Poly-Med, Inc. | Absorbable, permeability-modulated barrier composites and applications thereof |
CA2742599A1 (en) * | 2008-11-04 | 2010-05-14 | Tengion, Inc. | Cell-scaffold constructs |
WO2010057013A1 (en) | 2008-11-14 | 2010-05-20 | Wake Forest University Health Sciences | Selective cell therapy for the treatment of renal failure |
US8758447B2 (en) * | 2009-06-30 | 2014-06-24 | Ethicon, Inc. | Device and method for repair of urological structures |
US20100331963A1 (en) * | 2009-06-30 | 2010-12-30 | Jackie Donners | Method of Making Suture-Less Hollow Scaffolds |
WO2011004388A2 (en) * | 2009-07-08 | 2011-01-13 | Sridhar K Narasimhachar | An apparatus and method of culturing tubular autologous tissue graft |
US20110021869A1 (en) * | 2009-07-24 | 2011-01-27 | Hilary John Cholhan | Single-incision minimally-invasive surgical repair of pelvic organ/vaginal prolapse conditions |
FR2949688B1 (en) | 2009-09-04 | 2012-08-24 | Sofradim Production | FABRIC WITH PICOTS COATED WITH A BIORESORBABLE MICROPOROUS LAYER |
US20110065809A1 (en) * | 2009-09-15 | 2011-03-17 | Medtronic, Inc. | Polymerization of Multifunctional Azides, and Polymers Therefrom |
WO2011112626A1 (en) | 2010-03-09 | 2011-09-15 | Tengion, Inc. | Cell-scaffold constructs |
CN103025361B (en) * | 2010-05-03 | 2016-05-25 | 再生医学Tx有限责任公司 | Smooth muscle cell structure |
CA3065694A1 (en) | 2010-11-10 | 2012-05-18 | Inregen | Methods of forming injectable formulations for providing regenerative effects to an organ such as a kidney |
WO2012118799A2 (en) | 2011-02-28 | 2012-09-07 | President And Fellows Of Harvard College | Cell culture system |
ITMI20110386A1 (en) * | 2011-03-11 | 2012-09-12 | Antonio Sambusseti | HEAVY-DUTY HEADSET FOR VESCICALE ENLARGEMENT IN LOW COMPLIANCE PATIENTS |
FR2972626B1 (en) | 2011-03-16 | 2014-04-11 | Sofradim Production | PROSTHETIC COMPRISING A THREE-DIMENSIONAL KNIT AND ADJUSTED |
FR2977789B1 (en) | 2011-07-13 | 2013-07-19 | Sofradim Production | PROSTHETIC FOR UMBILIC HERNIA |
FR2977790B1 (en) | 2011-07-13 | 2013-07-19 | Sofradim Production | PROSTHETIC FOR UMBILIC HERNIA |
EP2760494B1 (en) | 2011-09-30 | 2017-04-19 | Sofradim Production | Reversible stiffening of light weight mesh |
WO2013086486A1 (en) | 2011-12-09 | 2013-06-13 | President And Fellows Of Harvard College | Integrated human organ-on-chip microphysiological systems |
FR2985170B1 (en) | 2011-12-29 | 2014-01-24 | Sofradim Production | PROSTHESIS FOR INGUINAL HERNIA |
FR2985271B1 (en) | 2011-12-29 | 2014-01-24 | Sofradim Production | KNITTED PICOTS |
WO2013151725A1 (en) | 2012-04-05 | 2013-10-10 | The Regents Of The University Of California | Regenerative sera cells and mesenchymal stem cells |
US20130317622A1 (en) * | 2012-05-25 | 2013-11-28 | Antonio Sambusseti | Surgical method for grafting an artificial implant in a bladder and/or in a urethral or ureteral segment |
FR2994185B1 (en) | 2012-08-02 | 2015-07-31 | Sofradim Production | PROCESS FOR THE PREPARATION OF A POROUS CHITOSAN LAYER |
FR2995788B1 (en) | 2012-09-25 | 2014-09-26 | Sofradim Production | HEMOSTATIC PATCH AND PREPARATION METHOD |
FR2995778B1 (en) | 2012-09-25 | 2015-06-26 | Sofradim Production | ABDOMINAL WALL REINFORCING PROSTHESIS AND METHOD FOR MANUFACTURING THE SAME |
FR2995779B1 (en) | 2012-09-25 | 2015-09-25 | Sofradim Production | PROSTHETIC COMPRISING A TREILLIS AND A MEANS OF CONSOLIDATION |
EP2900174B1 (en) | 2012-09-28 | 2017-04-12 | Sofradim Production | Packaging for a hernia repair device |
BR122020018576B1 (en) | 2012-10-24 | 2022-07-05 | Inregen | METHOD OF PREPARING AN APPROPRIATE THERAPEUTIC COMPOSITION TO GENERATE A REGENERATIVE RESPONSE IN A KIDNEY OF AN INDIVIDUAL, THERAPEUTIC COMPOSITION AND USE THEREOF |
FR3006578B1 (en) | 2013-06-07 | 2015-05-29 | Sofradim Production | PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY |
FR3006581B1 (en) | 2013-06-07 | 2016-07-22 | Sofradim Production | PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY |
US9855554B2 (en) | 2013-07-22 | 2018-01-02 | President And Fellows Of Harvard College | Microfluidic cartridge assembly |
JP2017504320A (en) | 2013-12-20 | 2017-02-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Low shear microfluidic device and methods of use and manufacture thereof |
RU2558980C1 (en) * | 2014-06-06 | 2015-08-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный педиатрический медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СПбГПМУ Минздрава России) | Method for enlarging split inverted urinary bladder within full-thickness defect and device for implementing it |
AU2015289999B2 (en) | 2014-07-14 | 2020-09-10 | President And Fellows Of Harvard College | Systems and methods for improved performance of fluidic and microfluidic systems |
EP3000489B1 (en) | 2014-09-24 | 2017-04-05 | Sofradim Production | Method for preparing an anti-adhesion barrier film |
EP3000433B1 (en) | 2014-09-29 | 2022-09-21 | Sofradim Production | Device for introducing a prosthesis for hernia treatment into an incision and flexible textile based prosthesis |
EP3000432B1 (en) | 2014-09-29 | 2022-05-04 | Sofradim Production | Textile-based prosthesis for treatment of inguinal hernia |
EP3029189B1 (en) | 2014-12-05 | 2021-08-11 | Sofradim Production | Prosthetic porous knit, method of making same and hernia prosthesis |
RU2572022C1 (en) * | 2014-12-30 | 2015-12-27 | Государственное автономное учреждение здравоохранения "Республиканская клиническая больница Министерства здравоохранения Республики Татарстан" | Method of treating congenital abnormal development of pelvic ring accompanying bladder extrophy |
EP3059255B1 (en) | 2015-02-17 | 2020-05-13 | Sofradim Production | Method for preparing a chitosan-based matrix comprising a fiber reinforcement member |
EP3085337B1 (en) | 2015-04-24 | 2022-09-14 | Sofradim Production | Prosthesis for supporting a breast structure |
ES2676072T3 (en) | 2015-06-19 | 2018-07-16 | Sofradim Production | Synthetic prosthesis comprising a knitted fabric and a non-porous film and method of forming it |
US10202569B2 (en) | 2015-07-24 | 2019-02-12 | President And Fellows Of Harvard College | Radial microfluidic devices and methods of use |
EP3195830B1 (en) | 2016-01-25 | 2020-11-18 | Sofradim Production | Prosthesis for hernia repair |
US9750591B1 (en) | 2016-07-29 | 2017-09-05 | Sam Sultan | Systems and methods for assisting patients in emptying their bladder efficiently |
EP3512935B1 (en) | 2016-09-13 | 2022-02-23 | President and Fellows of Harvard College | Methods relating to intestinal organ-on-a-chip |
EP3312325B1 (en) | 2016-10-21 | 2021-09-22 | Sofradim Production | Method for forming a mesh having a barbed suture attached thereto and the mesh thus obtained |
EP3398554A1 (en) | 2017-05-02 | 2018-11-07 | Sofradim Production | Prosthesis for inguinal hernia repair |
CN108295313B (en) * | 2018-03-15 | 2021-10-15 | 广州聚明生物科技有限公司 | Regenerative repair type lacrimal passage stent and preparation method thereof |
EP3653171A1 (en) | 2018-11-16 | 2020-05-20 | Sofradim Production | Implants suitable for soft tissue repair |
KR102213931B1 (en) * | 2019-09-16 | 2021-02-05 | 포항공과대학교 산학협력단 | Methods to develop the reconstituted miniature tissues with multiple cell types from patient-derived stem or tumor cells |
WO2024006421A1 (en) | 2022-07-01 | 2024-01-04 | The Regents Of The University Of California | Method to direct vascularization of tissue grafts |
Family Cites Families (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3463158A (en) * | 1963-10-31 | 1969-08-26 | American Cyanamid Co | Polyglycolic acid prosthetic devices |
JPS5492580A (en) | 1977-12-29 | 1979-07-21 | Nippon Zeon Co Ltd | Hollow fiber type material transferring apparatus |
US4182339A (en) * | 1978-05-17 | 1980-01-08 | Hardy Thomas G Jr | Anastomotic device and method |
SU1034717A1 (en) | 1981-04-22 | 1983-08-15 | Рижский Медицинский Институт | Method of application of vessel anastomosis |
US4458678A (en) | 1981-10-26 | 1984-07-10 | Massachusetts Institute Of Technology | Cell-seeding procedures involving fibrous lattices |
US4520821A (en) | 1982-04-30 | 1985-06-04 | The Regents Of The University Of California | Growing of long-term biological tissue correction structures in vivo |
US4594407A (en) * | 1983-09-20 | 1986-06-10 | Allied Corporation | Prosthetic devices derived from krebs-cycle dicarboxylic acids and diols |
FR2577807B1 (en) | 1985-02-22 | 1993-12-03 | Ethnor | ABSORBABLE COMPOSITE SURGICAL MATERIAL, PREPARATION METHOD, RESORBABLE PROSTHESIS MADE FROM SUCH MATERIAL AND USE OF SUCH A PROSTHESIS |
US5863531A (en) * | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
US5032508A (en) | 1988-09-08 | 1991-07-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
US5160490A (en) | 1986-04-18 | 1992-11-03 | Marrow-Tech Incorporated | Three-dimensional cell and tissue culture apparatus |
US5902741A (en) * | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
US5266480A (en) * | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
US4963489A (en) | 1987-04-14 | 1990-10-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
US4769037A (en) * | 1986-10-28 | 1988-09-06 | Midcalf Robert J | Artificial replacement kidney implant and method of dialyzing blood |
US5804178A (en) * | 1986-11-20 | 1998-09-08 | Massachusetts Institute Of Technology | Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue |
US5567612A (en) * | 1986-11-20 | 1996-10-22 | Massachusetts Institute Of Technology | Genitourinary cell-matrix structure for implantation into a human and a method of making |
CA1340581C (en) * | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
WO1989001967A1 (en) | 1987-09-03 | 1989-03-09 | Brown University Research Foundation | Blood purification with cultured renal cells |
GB8722854D0 (en) * | 1987-09-29 | 1987-11-04 | Hardy S M | Implantable artificial kidney |
US5085629A (en) * | 1988-10-06 | 1992-02-04 | Medical Engineering Corporation | Biodegradable stent |
JP3073766B2 (en) * | 1989-04-25 | 2000-08-07 | チルドレンズ メディカル センター コーポレイション | Method for transplanting large volumes of cells on a polymer matrix |
US4996154A (en) * | 1989-05-04 | 1991-02-26 | Millipore Corporation | Method for growing cellular tissue |
US5261898A (en) * | 1990-11-13 | 1993-11-16 | Polin Stanton G | Temporary colostomy apparatus |
US5192312A (en) | 1991-03-05 | 1993-03-09 | Colorado State University Research Foundation | Treated tissue for implantation and methods of treatment and use |
AU2900792A (en) * | 1991-10-24 | 1993-05-21 | Children's Medical Center Corporation | Neomorphogenesis of urological structures in vivo from cell culture |
US5376376A (en) * | 1992-01-13 | 1994-12-27 | Li; Shu-Tung | Resorbable vascular wound dressings |
US5549674A (en) | 1992-03-02 | 1996-08-27 | The Regents Of The University Of Michigan | Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo |
US5429938A (en) | 1992-03-02 | 1995-07-04 | University Of Michigan | Methods and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules |
US5441870A (en) * | 1992-04-15 | 1995-08-15 | Athena Neurosciences, Inc. | Methods for monitoring cellular processing of β-amyloid precursor protein |
EP0637229B1 (en) * | 1992-04-24 | 2002-11-20 | Osteotech, Inc., | Devices for preventing tissue adhesion |
US5224953A (en) * | 1992-05-01 | 1993-07-06 | The Beth Israel Hospital Association | Method for treatment of obstructive portions of urinary passageways |
US5800537A (en) * | 1992-08-07 | 1998-09-01 | Tissue Engineering, Inc. | Method and construct for producing graft tissue from an extracellular matrix |
US5957972A (en) * | 1992-09-29 | 1999-09-28 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Implants possessing a surface of endothelial cells genetically-modified to inhibit intimal thickening |
US5514378A (en) | 1993-02-01 | 1996-05-07 | Massachusetts Institute Of Technology | Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures |
US5433996A (en) * | 1993-02-18 | 1995-07-18 | W. L. Gore & Associates, Inc. | Laminated patch tissue repair sheet material |
US5709854A (en) * | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
AU1931495A (en) * | 1994-03-14 | 1995-10-03 | Cryolife, Inc. | Treated tissue for implantation and preparation methods |
US5916265A (en) * | 1994-03-30 | 1999-06-29 | Hu; Jie | Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant |
US5626861A (en) * | 1994-04-01 | 1997-05-06 | Massachusetts Institute Of Technology | Polymeric-hydroxyapatite bone composite |
US5947893A (en) * | 1994-04-27 | 1999-09-07 | Board Of Regents, The University Of Texas System | Method of making a porous prothesis with biodegradable coatings |
US5545131A (en) * | 1994-04-28 | 1996-08-13 | White Eagle International Technologies, Lp | Artificial kidney |
NZ293419A (en) | 1994-09-12 | 1998-11-25 | Advanced Tissue Sciences Inc | Stromal cell-coated heart valves, production thereof |
US5429674A (en) * | 1994-09-12 | 1995-07-04 | Ppg Industries, Inc. | N-acyl aminomethylene phosphonates and their use in waterborne coating compositions |
US5654273A (en) | 1994-09-22 | 1997-08-05 | Children's Medical Center Corporation | Synducin mediated modulation of tissue repair |
US5695996A (en) | 1994-09-23 | 1997-12-09 | The United States Of America As Represented By The Department Of Health And Human Services | Artificial organ culture system |
US5716404A (en) * | 1994-12-16 | 1998-02-10 | Massachusetts Institute Of Technology | Breast tissue engineering |
US5575818A (en) * | 1995-02-14 | 1996-11-19 | Corvita Corporation | Endovascular stent with locking ring |
EP0820301B1 (en) * | 1995-04-07 | 2002-07-24 | Purdue Research Foundation | Tissue graft for urinary bladder reconstruction |
US5855610A (en) * | 1995-05-19 | 1999-01-05 | Children's Medical Center Corporation | Engineering of strong, pliable tissues |
US5609629A (en) * | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
US6171344B1 (en) * | 1996-08-16 | 2001-01-09 | Children's Medical Center Corporation | Bladder submucosa seeded with cells for tissue reconstruction |
CA2263144A1 (en) * | 1996-08-16 | 1998-02-19 | Children's Medical Center Corporation | Bladder submucosa seeded with cells for tissue reconstruction |
EP0929271B1 (en) | 1996-09-05 | 2004-02-25 | Children's Medical Center Corporation | Prosthetic kidney |
US5967972A (en) * | 1997-03-28 | 1999-10-19 | Kapp Surgical Instrument, Inc. | Minimally invasive surgical retractor and method of operation |
EP0987998B1 (en) | 1997-04-11 | 2004-10-13 | CryoLife, Inc. | Tissue decellularization |
DE19828726A1 (en) | 1997-06-27 | 1999-01-07 | Augustinus Dr Bader | Preparation of bio-artificial transplant |
DE69817863T2 (en) * | 1997-10-31 | 2004-07-15 | Children's Medical Center Corp., Boston | BLADDER RECONSTRUCTION |
JP4162378B2 (en) | 1997-10-31 | 2008-10-08 | チルドレンズ メディカル センター コーポレーション | Penis reconstruction |
DE19804188A1 (en) | 1998-02-03 | 1999-08-05 | Siemens Ag | Radio |
DE19919625C2 (en) | 1999-04-29 | 2002-10-31 | Symetis Ag Zuerich | In vitro method for producing a homologous heart valve and valve that can be produced by this method |
GB9910377D0 (en) | 1999-05-05 | 1999-06-30 | Univ Westminster | Tissue engineering |
JP2001017572A (en) | 1999-07-09 | 2001-01-23 | Bridgestone Sports Co Ltd | Solid golf ball |
JP3603179B2 (en) | 1999-09-09 | 2004-12-22 | グンゼ株式会社 | Cardiovascular tissue culture substrate and tissue regeneration method |
US6428802B1 (en) | 1999-12-29 | 2002-08-06 | Children's Medical Center Corp. | Preparing artificial organs by forming polylayers of different cell populations on a substrate |
US6376244B1 (en) * | 1999-12-29 | 2002-04-23 | Children's Medical Center Corporation | Methods and compositions for organ decellularization |
US6656488B2 (en) * | 2001-04-11 | 2003-12-02 | Ethicon Endo-Surgery, Inc. | Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering |
JP5416415B2 (en) * | 2006-02-10 | 2014-02-12 | テンジオン, インコーポレイテッド | Skeleton for organ reconstruction and augmentation |
-
1998
- 1998-10-30 DE DE69817863T patent/DE69817863T2/en not_active Expired - Lifetime
- 1998-10-30 US US09/600,455 patent/US6576019B1/en not_active Expired - Lifetime
- 1998-10-30 AU AU11259/99A patent/AU747166B2/en not_active Ceased
- 1998-10-30 JP JP2000518711A patent/JP4057781B2/en not_active Expired - Fee Related
- 1998-10-30 EP EP98954037A patent/EP1032435B1/en not_active Expired - Lifetime
- 1998-10-30 AT AT98954037T patent/ATE248615T1/en not_active IP Right Cessation
- 1998-10-30 WO PCT/US1998/022962 patent/WO1999022781A2/en active IP Right Grant
- 1998-10-30 CA CA002307567A patent/CA2307567C/en not_active Expired - Fee Related
-
2003
- 2003-03-21 US US10/394,640 patent/US7569076B2/en not_active Expired - Fee Related
-
2009
- 2009-05-20 US US12/468,983 patent/US8128707B2/en not_active Expired - Fee Related
-
2012
- 2012-01-06 US US13/344,644 patent/US20120107403A1/en not_active Abandoned
-
2013
- 2013-07-15 US US13/941,985 patent/US20130304230A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU747166B2 (en) | 2002-05-09 |
US7569076B2 (en) | 2009-08-04 |
US20130304230A1 (en) | 2013-11-14 |
AU1125999A (en) | 1999-05-24 |
JP2001521789A (en) | 2001-11-13 |
US20120107403A1 (en) | 2012-05-03 |
DE69817863D1 (en) | 2003-10-09 |
JP4057781B2 (en) | 2008-03-05 |
DE69817863T2 (en) | 2004-07-15 |
WO1999022781A3 (en) | 1999-07-29 |
EP1032435A2 (en) | 2000-09-06 |
ATE248615T1 (en) | 2003-09-15 |
US8128707B2 (en) | 2012-03-06 |
US6576019B1 (en) | 2003-06-10 |
US20090263464A1 (en) | 2009-10-22 |
CA2307567C (en) | 2009-01-20 |
EP1032435B1 (en) | 2003-09-03 |
US20040034435A1 (en) | 2004-02-19 |
WO1999022781A2 (en) | 1999-05-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2307567A1 (en) | Polymer matrix/cell construct for bladder reconstruction | |
CA1293596C (en) | Semipermeable nerve guidance channels | |
CA2304296A1 (en) | Pelvic floor reconstruction | |
Itoh et al. | Evaluation of cross-linking procedures of collagen tubes used in peripheral nerve repair | |
CA2158638A1 (en) | A Composition and a Method for Tissue Augmentation | |
Capozzi et al. | Clinical experience with polyurethane-covered gel-filled mammary prostheses | |
AU5441396A (en) | Tissue graft and method for urinary bladder reconstruction | |
ES2186688T3 (en) | KIT FOR THE INCREASE OF SOFT FABRICS. | |
CA2183263A1 (en) | Improved process for fixation of calcification-resistant biological tissue | |
WO2003094786A8 (en) | Prosthetic repair fabric | |
AU6040494A (en) | Prosthesis for treating a natural channel or lumen, particularly an endo-urethral prosthesis | |
SE9603540D0 (en) | Orthopedic device | |
CA2201526A1 (en) | Differentially biodegradable biomedical implants | |
ATE275986T1 (en) | MEMORY THERMOPLASTIC AND POLYMER NETWORKS FOR TISSUE CONSTRUCTION | |
ES2177768T3 (en) | TISSUE GRAFT DERIVED FROM URINARY BLADDER SUBMUCOSE. | |
CA2395674A1 (en) | Methods and compositions for reconstruction of multilayered tissue structures | |
BRPI0416638A (en) | devices for implantation into a pelvis and for treatment of a pelvic organ prolapse, implantable suture-free device for supporting a pelvic organ, and method for treating prolapse of a pelvic organ | |
EP1643944A2 (en) | Expandable tissue support member and method of forming the support member | |
WO2001080921A3 (en) | Native protein mimetic fibers, fiber networks and fabrics for medical use | |
ATE415907T1 (en) | SOLID IMPLANT | |
WO2002039889A3 (en) | Implantable orthopedic support apparatus and method for making same | |
CA2334368A1 (en) | Bioengineered tubular graft prostheses | |
DE69734393D1 (en) | EYEBALL GRAFT | |
McVicar et al. | Self-reinforced polyglycolic acid membrane: a bioresorbable material for orbital floor repair. Initial clinical report | |
WO2002017880A3 (en) | Nitric oxide-producing hydrogel materials |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20151030 |