CA2300203A1 - Systeme microfluidique a regulation electrofluidique et electrothermique - Google Patents
Systeme microfluidique a regulation electrofluidique et electrothermique Download PDFInfo
- Publication number
- CA2300203A1 CA2300203A1 CA002300203A CA2300203A CA2300203A1 CA 2300203 A1 CA2300203 A1 CA 2300203A1 CA 002300203 A CA002300203 A CA 002300203A CA 2300203 A CA2300203 A CA 2300203A CA 2300203 A1 CA2300203 A1 CA 2300203A1
- Authority
- CA
- Canada
- Prior art keywords
- channel
- fluid
- temperature
- current
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
- B01L2200/147—Employing temperature sensors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1833—Means for temperature control using electrical currents in the sample itself
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1838—Means for temperature control using fluid heat transfer medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Electrochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
La présente invention concerne un procédé et un dispositif de transport et/ou de surveillance d'un fluide dans un dispositif multiport utilisé dans un système microfluidique. Le dispositif multiport inclut un substrat comprenant une configuration définie du canal. Une première région du canal, définie dans le substrat, comporte un premier port et un second port permettant de transporter entre eux le fluide. Une seconde région du canal, également définie dans le substrat, comporte un premier port et un second port permettant d'appliquer un courant électrique servant à réchauffer le fluide ou à surveiller entre eux un paramètre du fluide. Selon certaines réalisations, le premier canal coupe le second canal. Les aspects chauffage ou surveillance de l'invention conviennent à une multitude de réactions biologiques, y compris l'amplification en chaîne par polymérase et la ligation répétitive d'oligonucléotides.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002510539A CA2510539A1 (fr) | 1997-09-02 | 1998-08-27 | Systeme microfluidique a regulation electrofluidique et electrothermique |
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5605897P | 1997-09-02 | 1997-09-02 | |
US60/056,058 | 1997-09-02 | ||
US08/977,528 US5965410A (en) | 1997-09-02 | 1997-11-25 | Electrical current for controlling fluid parameters in microchannels |
US08/977,528 | 1997-11-25 | ||
US8353298P | 1998-04-29 | 1998-04-29 | |
US60/083,532 | 1998-04-29 | ||
PCT/US1998/017910 WO1999012016A1 (fr) | 1997-09-02 | 1998-08-27 | Systeme microfluidique a regulation electrofluidique et electrothermique |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002510539A Division CA2510539A1 (fr) | 1997-09-02 | 1998-08-27 | Systeme microfluidique a regulation electrofluidique et electrothermique |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2300203A1 true CA2300203A1 (fr) | 1999-03-11 |
Family
ID=27368961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002300203A Abandoned CA2300203A1 (fr) | 1997-09-02 | 1998-08-27 | Systeme microfluidique a regulation electrofluidique et electrothermique |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1009995A4 (fr) |
JP (1) | JP2001515204A (fr) |
AU (1) | AU746098B2 (fr) |
CA (1) | CA2300203A1 (fr) |
WO (1) | WO1999012016A1 (fr) |
Families Citing this family (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
CA2258489C (fr) | 1996-06-28 | 2004-01-27 | Caliper Technologies Corporation | Systeme de dosage de criblage a fort rendement dans des dispositifs microscopiques de transfert de fluides |
CN1105914C (zh) * | 1997-04-25 | 2003-04-16 | 卡钳技术有限公司 | 改进了通道几何结构的微型流体装置 |
US7033474B1 (en) | 1997-04-25 | 2006-04-25 | Caliper Life Sciences, Inc. | Microfluidic devices incorporating improved channel geometries |
US6524790B1 (en) | 1997-06-09 | 2003-02-25 | Caliper Technologies Corp. | Apparatus and methods for correcting for variable velocity in microfluidic systems |
US5989402A (en) | 1997-08-29 | 1999-11-23 | Caliper Technologies Corp. | Controller/detector interfaces for microfluidic systems |
US7497994B2 (en) | 1998-02-24 | 2009-03-03 | Khushroo Gandhi | Microfluidic devices and systems incorporating cover layers |
US6756019B1 (en) | 1998-02-24 | 2004-06-29 | Caliper Technologies Corp. | Microfluidic devices and systems incorporating cover layers |
US6251343B1 (en) | 1998-02-24 | 2001-06-26 | Caliper Technologies Corp. | Microfluidic devices and systems incorporating cover layers |
WO1999064836A1 (fr) | 1998-06-08 | 1999-12-16 | Caliper Technologies Corp. | Dispositifs microfluidiques, systemes et procedes pour realiser des reactions et des separations integrees |
US6306590B1 (en) | 1998-06-08 | 2001-10-23 | Caliper Technologies Corp. | Microfluidic matrix localization apparatus and methods |
US6716394B2 (en) | 1998-08-11 | 2004-04-06 | Caliper Technologies Corp. | DNA sequencing using multiple fluorescent labels being distinguishable by their decay times |
US6447724B1 (en) | 1998-08-11 | 2002-09-10 | Caliper Technologies Corp. | DNA sequencing using multiple fluorescent labels being distinguishable by their decay times |
US6149787A (en) | 1998-10-14 | 2000-11-21 | Caliper Technologies Corp. | External material accession systems and methods |
US6416642B1 (en) | 1999-01-21 | 2002-07-09 | Caliper Technologies Corp. | Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection |
ATE508200T1 (de) | 1999-02-23 | 2011-05-15 | Caliper Life Sciences Inc | Sequenzierung durch inkorporation |
US6326083B1 (en) | 1999-03-08 | 2001-12-04 | Calipher Technologies Corp. | Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety |
CN1181337C (zh) | 2000-08-08 | 2004-12-22 | 清华大学 | 微流体***中实体分子的操纵方法及相关试剂盒 |
US6500323B1 (en) | 1999-03-26 | 2002-12-31 | Caliper Technologies Corp. | Methods and software for designing microfluidic devices |
US6303343B1 (en) | 1999-04-06 | 2001-10-16 | Caliper Technologies Corp. | Inefficient fast PCR |
US6349740B1 (en) * | 1999-04-08 | 2002-02-26 | Abbott Laboratories | Monolithic high performance miniature flow control unit |
US6458259B1 (en) | 1999-05-11 | 2002-10-01 | Caliper Technologies Corp. | Prevention of surface adsorption in microchannels by application of electric current during pressure-induced flow |
CA2373347A1 (fr) | 1999-05-17 | 2000-11-23 | Caliper Technologies Corporation | Focalisation de microparticules dans des systemes microfluidiques |
US6592821B1 (en) | 1999-05-17 | 2003-07-15 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems |
WO2000073799A1 (fr) | 1999-06-01 | 2000-12-07 | Caliper Technologies Corp. | Dosages a micro-echelle et dispositifs microfluidiques destines au controle des activites de transporteur, de gradient induit et de liaison |
WO2001002850A1 (fr) | 1999-07-06 | 2001-01-11 | Caliper Technologies Corp. | Systemes et methodes microfluidiques permettant de determiner la cinetique d'un modulateur |
EP1203096B1 (fr) | 1999-07-28 | 2008-12-31 | Merck Serono Biodevelopment | Dispositif microfluidique dans lequel un changement de température locale agit sur un echantillon en flux continu |
US6977145B2 (en) | 1999-07-28 | 2005-12-20 | Serono Genetics Institute S.A. | Method for carrying out a biochemical protocol in continuous flow in a microreactor |
US6858185B1 (en) | 1999-08-25 | 2005-02-22 | Caliper Life Sciences, Inc. | Dilutions in high throughput systems with a single vacuum source |
EP1208240A4 (fr) * | 1999-08-26 | 2006-10-04 | Univ Princeton | Dispositifs electroniques microfluidiques et nanofluidiques permettant de detecter des modifications de la capacite de fluides et techniques d'utilisation |
US6613581B1 (en) | 1999-08-26 | 2003-09-02 | Caliper Technologies Corp. | Microfluidic analytic detection assays, devices, and integrated systems |
CA2385618A1 (fr) | 1999-10-08 | 2001-04-19 | Caliper Technologies Corporation | Utilisation de teintures sensibles au potentiel de nernst pour mesurer le potentiel transmembranaire |
US6884395B2 (en) | 2000-05-12 | 2005-04-26 | Gyros Ab | Integrated microfluidic disc |
EP1738829A1 (fr) * | 2000-01-04 | 2007-01-03 | The Regents of the University of California | Systeme d'amplification en chaine par polymerase |
US6699713B2 (en) | 2000-01-04 | 2004-03-02 | The Regents Of The University Of California | Polymerase chain reaction system |
US6468761B2 (en) | 2000-01-07 | 2002-10-22 | Caliper Technologies, Corp. | Microfluidic in-line labeling method for continuous-flow protease inhibition analysis |
US7037416B2 (en) | 2000-01-14 | 2006-05-02 | Caliper Life Sciences, Inc. | Method for monitoring flow rate using fluorescent markers |
US6556923B2 (en) | 2000-01-26 | 2003-04-29 | Caliper Technologies Corp. | Software for high throughput microfluidic systems |
US20020012971A1 (en) | 2000-03-20 | 2002-01-31 | Mehta Tammy Burd | PCR compatible nucleic acid sieving medium |
US6733645B1 (en) | 2000-04-18 | 2004-05-11 | Caliper Technologies Corp. | Total analyte quantitation |
US6669831B2 (en) | 2000-05-11 | 2003-12-30 | Caliper Technologies Corp. | Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers |
CA2407141A1 (fr) | 2000-05-12 | 2001-11-22 | Caliper Technologies Corporation | Detection de l'hybridation d'acides nucleiques par fluorescence |
WO2002001081A2 (fr) * | 2000-06-23 | 2002-01-03 | Micronics, Inc. | Valve pour structures microfluidiques |
AU2001284700B2 (en) | 2000-08-03 | 2005-12-08 | Caliper Life Sciences, Inc. | Methods and devices for high throughput fluid delivery |
JP3993372B2 (ja) * | 2000-09-13 | 2007-10-17 | 独立行政法人理化学研究所 | リアクタの製造方法 |
ATE448875T1 (de) * | 2000-09-14 | 2009-12-15 | Caliper Life Sciences Inc | Mikrofluidische vorrichtungen und methoden um temperatur-vermittelte reaktionen durchzuführen |
CN100495030C (zh) | 2000-09-30 | 2009-06-03 | 清华大学 | 多力操纵装置及其应用 |
US7150815B2 (en) | 2000-10-05 | 2006-12-19 | E. I. Du Pont De Nemours And Company | Polymeric microfabricated fluidic device suitable for ultraviolet detection |
US20090118139A1 (en) | 2000-11-07 | 2009-05-07 | Caliper Life Sciences, Inc. | Microfluidic method and system for enzyme inhibition activity screening |
US8900811B2 (en) | 2000-11-16 | 2014-12-02 | Caliper Life Sciences, Inc. | Method and apparatus for generating thermal melting curves in a microfluidic device |
AU2002217067A1 (en) * | 2000-11-29 | 2002-06-11 | Proteologics Inc. | Method and apparatus for decoupling temperature and electric field in electrophoresis separation |
JP3628611B2 (ja) * | 2000-11-29 | 2005-03-16 | 独立行政法人科学技術振興機構 | マイクロシステムにおける流れの制御方法 |
US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
JP3941537B2 (ja) * | 2001-02-28 | 2007-07-04 | ソニー株式会社 | 熱輸送装置 |
US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
US6575188B2 (en) * | 2001-07-26 | 2003-06-10 | Handylab, Inc. | Methods and systems for fluid control in microfluidic devices |
US7723123B1 (en) | 2001-06-05 | 2010-05-25 | Caliper Life Sciences, Inc. | Western blot by incorporating an affinity purification zone |
EP1417474B1 (fr) * | 2001-07-25 | 2021-12-29 | The Trustees Of Princeton University | Reseaux de nanocanaux, leurs preparation et utilisation dans l'analyse macromoleculaire a rendement eleve |
US9678038B2 (en) | 2001-07-25 | 2017-06-13 | The Trustees Of Princeton University | Nanochannel arrays and their preparation and use for high throughput macromolecular analysis |
JP2003149252A (ja) * | 2001-11-16 | 2003-05-21 | Starlite Co Ltd | 化学マイクロデバイス |
AU2003228277B2 (en) | 2002-03-05 | 2006-06-29 | Caliper Life Sciences, Inc. | Mixed mode microfluidic systems |
WO2004029079A1 (fr) * | 2002-09-25 | 2004-04-08 | Tokyo University Of Agriculture And Technology Tlo Co., Ltd. | Methode de purification d'un complexe proteinique, methode d'analyse et dispositif d'analyse |
JP2006523142A (ja) | 2003-04-10 | 2006-10-12 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体種の形成および制御 |
AU2004245094A1 (en) | 2003-06-06 | 2004-12-16 | Perkinelmer Health Sciences, Inc. | System and method for heating, cooling and heat cycling on microfluidic device |
US7648835B2 (en) | 2003-06-06 | 2010-01-19 | Micronics, Inc. | System and method for heating, cooling and heat cycling on microfluidic device |
DE10332289B4 (de) * | 2003-07-16 | 2018-06-14 | Disetronic Licensing Ag | Fluidsystem mit Sicherungseinrichtung |
US7731906B2 (en) | 2003-07-31 | 2010-06-08 | Handylab, Inc. | Processing particle-containing samples |
EP2662135A3 (fr) | 2003-08-27 | 2013-12-25 | President and Fellows of Harvard College | Méthode de mélange de gouttelettes dans un microcanal |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
JP2006145516A (ja) * | 2004-07-14 | 2006-06-08 | Ebara Corp | マイクロチャンネルチップ反応制御システム、それを含むマイクロトータルリアクションシステムおよびマイクロトータルアナリシスシステム |
WO2006006679A1 (fr) * | 2004-07-14 | 2006-01-19 | Ebara Corporation | Système de commande de réaction de puce à microcanal, système de réaction micrototal possédant ledit système et système d’analyse micrototale |
EP1637228A1 (fr) * | 2004-09-16 | 2006-03-22 | Roche Diagnostics GmbH | Procédé et dispositif pour réaliser des cyclages thermiques rapides et systeme microfluidique |
WO2007075919A2 (fr) * | 2005-12-22 | 2007-07-05 | Honeywell International Inc. | Systeme d'analyseur portatif d'echantillons |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
JP5415253B2 (ja) | 2006-03-24 | 2014-02-12 | ハンディラブ・インコーポレーテッド | 微小流体サンプルを処理するための一体化システム及びその使用方法 |
US8709787B2 (en) | 2006-11-14 | 2014-04-29 | Handylab, Inc. | Microfluidic cartridge and method of using same |
CN101765462B (zh) | 2007-03-28 | 2013-06-05 | 博纳基因技术有限公司 | 使用纳米通道阵列的大分子分析方法 |
EP2152893B1 (fr) * | 2007-06-11 | 2014-02-26 | Wako Pure Chemical Industries, Ltd. | Procédé d'amplification d'acide nucléique par PCR sur micropuce avec détection par CE intégrée en temps réel |
US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
CA2693654C (fr) | 2007-07-13 | 2018-02-13 | Handylab, Inc. | Matieres absorbant les polynucleotides, et procedes d'utilisation de celles-ci |
US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
JP5279926B2 (ja) * | 2011-03-23 | 2013-09-04 | アークレイ株式会社 | 分析装置、及び分析方法 |
EP3159697B1 (fr) | 2011-04-15 | 2019-12-25 | Becton, Dickinson and Company | Balayage de thermocycleur microfluidique en temps réel |
USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
ES2825905T3 (es) | 2011-09-30 | 2021-05-17 | Becton Dickinson Co | Tira reactiva unificada |
EP2773892B1 (fr) | 2011-11-04 | 2020-10-07 | Handylab, Inc. | Dispositif de préparation d'échantillons de polynucléotides |
CA2863637C (fr) | 2012-02-03 | 2021-10-26 | Becton, Dickinson And Company | Fichiers externes servant a repartir des tests de diagnostic moleculaire et a determiner la compatibilite entre les tests |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5252293A (en) * | 1989-01-17 | 1993-10-12 | Vladimir Drbal | Analytical slide with porous filter membrane |
US5587128A (en) * | 1992-05-01 | 1996-12-24 | The Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification devices |
US5498392A (en) * | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
US5637469A (en) * | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
US5639423A (en) * | 1992-08-31 | 1997-06-17 | The Regents Of The University Of Calfornia | Microfabricated reactor |
DE69331996T2 (de) * | 1992-09-14 | 2002-12-05 | Purdue Research Foundation, West Lafayette | Chemische Analyse durch Elektrophorese |
CA2157373C (fr) * | 1993-03-05 | 2005-06-07 | Janusz B. Pawliszyn | Methode et dispositif d'electrofocalisation sans ampholytes porteurs |
US6001229A (en) * | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
US5571410A (en) * | 1994-10-19 | 1996-11-05 | Hewlett Packard Company | Fully integrated miniaturized planar liquid sample handling and analysis device |
US5641400A (en) * | 1994-10-19 | 1997-06-24 | Hewlett-Packard Company | Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems |
US6132580A (en) * | 1995-09-28 | 2000-10-17 | The Regents Of The University Of California | Miniature reaction chamber and devices incorporating same |
US5779868A (en) * | 1996-06-28 | 1998-07-14 | Caliper Technologies Corporation | Electropipettor and compensation means for electrophoretic bias |
US5800690A (en) * | 1996-07-03 | 1998-09-01 | Caliper Technologies Corporation | Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces |
US5699157A (en) * | 1996-07-16 | 1997-12-16 | Caliper Technologies Corp. | Fourier detection of species migrating in a microchannel |
-
1998
- 1998-08-27 EP EP98944596A patent/EP1009995A4/fr not_active Withdrawn
- 1998-08-27 WO PCT/US1998/017910 patent/WO1999012016A1/fr active IP Right Grant
- 1998-08-27 JP JP2000508970A patent/JP2001515204A/ja active Pending
- 1998-08-27 CA CA002300203A patent/CA2300203A1/fr not_active Abandoned
- 1998-08-27 AU AU92103/98A patent/AU746098B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU9210398A (en) | 1999-03-22 |
EP1009995A1 (fr) | 2000-06-21 |
AU746098B2 (en) | 2002-04-18 |
JP2001515204A (ja) | 2001-09-18 |
EP1009995A4 (fr) | 2007-05-02 |
WO1999012016A1 (fr) | 1999-03-11 |
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EEER | Examination request | ||
FZDE | Discontinued |