CA2288439A1 - Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin - Google Patents

Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin Download PDF

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Publication number
CA2288439A1
CA2288439A1 CA002288439A CA2288439A CA2288439A1 CA 2288439 A1 CA2288439 A1 CA 2288439A1 CA 002288439 A CA002288439 A CA 002288439A CA 2288439 A CA2288439 A CA 2288439A CA 2288439 A1 CA2288439 A1 CA 2288439A1
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CA
Canada
Prior art keywords
biphenylsulfonamides
endothelin
activity
methods
modulate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002288439A
Other languages
French (fr)
Other versions
CA2288439C (en
Inventor
Ming Fai Chan
Bore Gowda Raju
Adam Kois
Erik Joel Verner
Chengde Wu
Rosario Sylvestre Castillo
Venkatachalapathi Yalamoori
Vitukudi Narayanaiyengar Balaji
Timothy Kogan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Encysive Pharmaceuticals Inc
Original Assignee
Texas Biotechnology Corporation
Ming Fai Chan
Bore Gowda Raju
Adam Kois
Erik Joel Verner
Chengde Wu
Rosario Sylvestre Castillo
Venkatachalapathi Yalamoori
Vitukudi Narayanaiyengar Balaji
Timothy Kogan
Immunopharmaceutics, Inc.
Castillo, Rosario Silverste
Encysive Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/477,223 external-priority patent/US5594021A/en
Application filed by Texas Biotechnology Corporation, Ming Fai Chan, Bore Gowda Raju, Adam Kois, Erik Joel Verner, Chengde Wu, Rosario Sylvestre Castillo, Venkatachalapathi Yalamoori, Vitukudi Narayanaiyengar Balaji, Timothy Kogan, Immunopharmaceutics, Inc., Castillo, Rosario Silverste, Encysive Pharmaceuticals Inc. filed Critical Texas Biotechnology Corporation
Priority claimed from CA002217169A external-priority patent/CA2217169C/en
Publication of CA2288439A1 publication Critical patent/CA2288439A1/en
Application granted granted Critical
Publication of CA2288439C publication Critical patent/CA2288439C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Biphenylsulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)biphenylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided.
Methods for treating endothelia-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelia are also provided. The biphenylsulfonamides have formula I:

where Ar2 is:
CA002288439A 1995-04-04 1996-04-04 Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin Expired - Fee Related CA2288439C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US41707595A 1995-04-04 1995-04-04
US41619995A 1995-04-04 1995-04-04
US08/417,075 1995-04-04
US08/416,199 1995-04-04
US08/477,223 US5594021A (en) 1993-05-20 1995-06-06 Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
US08/477,226 1995-06-06
CA002217169A CA2217169C (en) 1995-04-04 1996-04-04 Thienyl-, furyl-, pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002217169A Division CA2217169C (en) 1995-04-04 1996-04-04 Thienyl-, furyl-, pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA 2420614 Division CA2420614A1 (en) 1995-04-04 1996-04-04 Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin

Publications (2)

Publication Number Publication Date
CA2288439A1 true CA2288439A1 (en) 1996-10-10
CA2288439C CA2288439C (en) 2003-04-01

Family

ID=27427394

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002288439A Expired - Fee Related CA2288439C (en) 1995-04-04 1996-04-04 Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin

Country Status (1)

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CA (1) CA2288439C (en)

Also Published As

Publication number Publication date
CA2288439C (en) 2003-04-01

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