CA2285628A1 - Polypeptides ligands pour le recepteur couple a la proteine g, provenant de l'hypohyse humaine - Google Patents

Polypeptides ligands pour le recepteur couple a la proteine g, provenant de l'hypohyse humaine Download PDF

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Publication number
CA2285628A1
CA2285628A1 CA002285628A CA2285628A CA2285628A1 CA 2285628 A1 CA2285628 A1 CA 2285628A1 CA 002285628 A CA002285628 A CA 002285628A CA 2285628 A CA2285628 A CA 2285628A CA 2285628 A1 CA2285628 A1 CA 2285628A1
Authority
CA
Canada
Prior art keywords
dna
protein
seq
polypeptide
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002285628A
Other languages
English (en)
Inventor
Shuji Hinuma
Shoji Fukusumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2285628A1 publication Critical patent/CA2285628A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention porte sur le polypeptide ligand d'origine murine pour les protéines réceptrices couplées à la protéine G. Le polypeptide ligand ou l'ADN qui code ce polypeptide ligand peuvent être utilisés pour (1) la mise au point de médicaments tels que modulateurs de la fonction hypophysaire, modulateurs de la fonction du système nerveux central et modulateurs de la fonction pancréatique, (2) l'élaboration de méthodes pour tester la liaison des récepteurs utilisant l'expression de protéines réceptrices de recombinaison et la sélection de composés pharmaceutiques d'intérêt potentiel et (3) la production d'animaux non humains transgéniques ou d'animaux non humains porteurs de gènes inactivés permettant l'analyse d'une fonction génique.
CA002285628A 1997-04-28 1998-04-27 Polypeptides ligands pour le recepteur couple a la proteine g, provenant de l'hypohyse humaine Abandoned CA2285628A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10997497 1997-04-28
JP9-109974 1997-04-28
PCT/JP1998/001923 WO1998049295A1 (fr) 1997-04-28 1998-04-27 Polypeptides ligands pour le recepteur couple a la proteine g, provenant de l'hypohyse humaine

Publications (1)

Publication Number Publication Date
CA2285628A1 true CA2285628A1 (fr) 1998-11-05

Family

ID=14523880

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002285628A Abandoned CA2285628A1 (fr) 1997-04-28 1998-04-27 Polypeptides ligands pour le recepteur couple a la proteine g, provenant de l'hypohyse humaine

Country Status (4)

Country Link
EP (1) EP0981616A1 (fr)
AU (1) AU7081798A (fr)
CA (1) CA2285628A1 (fr)
WO (1) WO1998049295A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3733199A (en) 1998-05-21 1999-12-06 Takeda Chemical Industries Ltd. Antibodies and utilization thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0776367B8 (fr) * 1994-08-09 2003-12-03 The Regents Of The University Of Minnesota Adn codant un peptide intestinal vasoactif hypothalamique de dinde
CA2195768A1 (fr) * 1994-08-11 1996-02-22 Shuji Hinuma Proteine receptrice couplee a une proteine g, sa production et son utilisation
AU7011896A (en) * 1995-08-29 1997-03-19 Chiron Corporation Human hypothalmic ("hr") receptor polypeptide compositions, methods and uses thereof
CN1149286C (zh) * 1995-12-28 2004-05-12 武田药品工业株式会社 G蛋白偶联受体蛋白的配体多肽及其生产方法和用途

Also Published As

Publication number Publication date
EP0981616A1 (fr) 2000-03-01
AU7081798A (en) 1998-11-24
WO1998049295A1 (fr) 1998-11-05

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Legal Events

Date Code Title Description
FZDE Discontinued