CA2271770A1 - Procede de detection du cancer de la prostate metastatique - Google Patents

Procede de detection du cancer de la prostate metastatique Download PDF

Info

Publication number
CA2271770A1
CA2271770A1 CA002271770A CA2271770A CA2271770A1 CA 2271770 A1 CA2271770 A1 CA 2271770A1 CA 002271770 A CA002271770 A CA 002271770A CA 2271770 A CA2271770 A CA 2271770A CA 2271770 A1 CA2271770 A1 CA 2271770A1
Authority
CA
Canada
Prior art keywords
dna
oligonucleotide
amount
seq
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002271770A
Other languages
English (en)
Inventor
Donald J. Tindall
Charles Y. F. Young
Daniel J. Mccormick
George G. Klee
Mohammad Saeed Saedi
Abhay Kumar
Harry G. Rittenhouse
Robert L. Wolfert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hybritech Inc
Mayo Foundation for Medical Education and Research
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2271770A1 publication Critical patent/CA2271770A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

Selon le procédé de la présente invention, on détecte le cancer de la prostate en déterminant la présence d'un polypeptide glandullaire spécifique de la prostate appelé Kallikrein (hK2) ou d'un ARN de hK2 dans un échantillon physiologique.
CA002271770A 1996-11-14 1997-11-14 Procede de detection du cancer de la prostate metastatique Abandoned CA2271770A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75935496A 1996-11-14 1996-11-14
US08/759,354 1996-11-14
PCT/US1997/020948 WO1998021365A2 (fr) 1996-11-14 1997-11-14 Procede de detection du cancer de la prostate metastatique

Publications (1)

Publication Number Publication Date
CA2271770A1 true CA2271770A1 (fr) 1998-05-22

Family

ID=25055346

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002271770A Abandoned CA2271770A1 (fr) 1996-11-14 1997-11-14 Procede de detection du cancer de la prostate metastatique

Country Status (6)

Country Link
EP (1) EP0941368A2 (fr)
JP (1) JP2001503991A (fr)
CN (1) CN1238013A (fr)
AU (1) AU737659B2 (fr)
CA (1) CA2271770A1 (fr)
WO (1) WO1998021365A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2360073C (fr) 1999-01-28 2011-01-18 Gen-Probe Incorporated Sondes et amorces pour la detection d'antigene prostatique specifique (psa) dans un echantillon biologique
FI990382A0 (fi) * 1999-02-23 1999-02-23 Arctic Partners Oy Ab Uusi diagnostinen menetelmä
US8663600B2 (en) 2005-02-17 2014-03-04 Diaprost Ab Diagnosis of prostate cancer
FR2906537A1 (fr) * 2006-09-28 2008-04-04 Biomerieux Sa Procede de diagnostic in vitro du cancer broncho-pulmonaire par detection des transcrits majoritaires alternatifs du gene klk8 codant la kallicreine 8 et son utilisation pour le pronostic de survie
ES2601459T3 (es) 2011-10-28 2017-02-15 Fredax Ab Agentes terapéuticos y usos de los mismos
WO2015075445A1 (fr) 2013-11-19 2015-05-28 Fredax Ab Anticorps anti-kallikréine-2 humanisé

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08502889A (ja) * 1992-10-29 1996-04-02 トーマス・ジェファーソン・ユニバーシティ 前立腺癌の微小転移を検出する方法
CA2187775A1 (fr) * 1994-04-15 1995-10-26 Aaron E. Katz Procede de d'evaluation au niveau moleculaire des stades d'evolution du cancer de la prostate
AU699748B2 (en) * 1994-05-10 1998-12-10 Hybritech Incorporated Recombinant HK2 polypeptide
AU4897896A (en) * 1995-01-04 1996-07-24 Trustees Of Boston University Primers for the pcr amplification of metastatic sequences
CA2212846A1 (fr) * 1995-02-24 1996-08-29 Sloan-Kettering Institute For Cancer Research Antigene membranaire specifique de la prostate et ses utilisations

Also Published As

Publication number Publication date
CN1238013A (zh) 1999-12-08
WO1998021365A3 (fr) 1998-10-15
EP0941368A2 (fr) 1999-09-15
JP2001503991A (ja) 2001-03-27
AU5260298A (en) 1998-06-03
AU737659B2 (en) 2001-08-23
WO1998021365A2 (fr) 1998-05-22

Similar Documents

Publication Publication Date Title
US6479263B1 (en) Method for detection of micrometastatic prostate cancer
JP4205738B2 (ja) 安定ｈｋ２ポリペプチド変異体
EP0948630B1 (fr) Clonage et caracterisation de napsine, une protease aspartique
WO1995030758A9 (fr) Polypeptide hk2 recombine
EP0804593A1 (fr) Polypeptide hk2 recombine
US6482599B1 (en) Forms of prostate specific antigen (PSA) specific for benign prostatic hyperplasia (BPH) and methods of using such
WO1998059073A1 (fr) Procede de detection du cancer du sein
AU739546B2 (en) Forms of prostate specific antigen and methods for their detection
AU737659B2 (en) Method for detection of metastatic prostate cancer
EP0974057B1 (fr) Procede de detection de polypeptides hk2
WO1998002748A9 (fr) Procede de detection de polypeptides hk2
EP1392719B1 (fr) Formes d'antigenes specifiques de la prostate et procedes de detection de ceux-ci
JP2002538818A (ja) 前立腺腫瘍組織におけるヒトカリクレイン２とプロテアーゼインヒビター−６の新規な複合体および該複合体の利用方法
US20040259113A1 (en) Method for detection of metastatic prostate cancer
MXPA99004504A (en) Method for detection of metastatic prostate cancer
MXPA99000659A (es) Metodos para detectar polipeptidos de hk2

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued