CA2269135A1 - Derives de benzodiazepine hydrazide utilises comme inhibiteurs de l'integrase du vih - Google Patents

Derives de benzodiazepine hydrazide utilises comme inhibiteurs de l'integrase du vih Download PDF

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Publication number
CA2269135A1
CA2269135A1 CA002269135A CA2269135A CA2269135A1 CA 2269135 A1 CA2269135 A1 CA 2269135A1 CA 002269135 A CA002269135 A CA 002269135A CA 2269135 A CA2269135 A CA 2269135A CA 2269135 A1 CA2269135 A1 CA 2269135A1
Authority
CA
Canada
Prior art keywords
pharmaceutically acceptable
thiamorpholinyl
heterocycle
hiv
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002269135A
Other languages
English (en)
Inventor
Ian M. Bell
James P. Guare, Jr.
Daria Jean Hazuda
Peter M. Munson
Wayne J. Thompson
Joseph P. Vacca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9624375.3A external-priority patent/GB9624375D0/en
Application filed by Individual filed Critical Individual
Publication of CA2269135A1 publication Critical patent/CA2269135A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur des composés possédant un noyau de benzodiazépine hydrazide. Ces composés sont utilisés dans l'inhibition de l'intégrase du VIH, la prévention ou le traitement des infections à VIH et dans le traitement du SIDA, que ce soit des composés, des sels pharmaceutiquement acceptables, des ingrédients de compositions pharmaceutiques, en combinaison ou non avec d'autres agents antiviraux, des immunomodulateurs, des antibiotiques ou des vaccins. Des procédés de traitement du SIDA et des procédés de prévention ou de traitement des infections à VIH sont également décrits.
CA002269135A 1996-10-31 1997-10-27 Derives de benzodiazepine hydrazide utilises comme inhibiteurs de l'integrase du vih Abandoned CA2269135A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2934896P 1996-10-31 1996-10-31
US60/029,348 1996-10-31
GB9624375.3 1996-11-22
GBGB9624375.3A GB9624375D0 (en) 1996-11-22 1996-11-22 Benzodiazepine hydrazide derivatives as inhibitors of HIV integrase
PCT/US1997/019230 WO1998018473A1 (fr) 1996-10-31 1997-10-27 Derives de benzodiazepine hydrazide utilises comme inhibiteurs de l'integrase du vih

Publications (1)

Publication Number Publication Date
CA2269135A1 true CA2269135A1 (fr) 1998-05-07

Family

ID=26310468

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002269135A Abandoned CA2269135A1 (fr) 1996-10-31 1997-10-27 Derives de benzodiazepine hydrazide utilises comme inhibiteurs de l'integrase du vih

Country Status (4)

Country Link
EP (1) EP0949926A4 (fr)
AU (1) AU4917397A (fr)
CA (1) CA2269135A1 (fr)
WO (1) WO1998018473A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002516858A (ja) * 1998-06-03 2002-06-11 メルク エンド カムパニー インコーポレーテッド Ｈｉｖインテグラーゼ阻害薬
WO2000059867A1 (fr) * 1999-03-30 2000-10-12 Pharmacor Inc. Derives d'hydroxyphenyle possedant des proprietes inhibitrices de l'integrase du vih
US6362165B1 (en) 1999-03-30 2002-03-26 Pharmacor Inc. Hydroxyphenyl derivatives with HIV integrase inhibitory properties
US6313177B1 (en) 1999-04-30 2001-11-06 Pharmacor Inc. D-mannitol derivatives as HIV aspartyl protease inhibitors
DE60035591D1 (de) * 1999-05-12 2007-08-30 Us Health Thiazepin-hemmer von hiv-1 integrase
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
EA012387B1 (ru) 2002-09-20 2009-10-30 Эрроу Терапьютикс Лимитед Производные бензодиазепина, содержащие их продукт и фармацевтическая композиция и их применение
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
WO2005103003A2 (fr) 2004-04-26 2005-11-03 Pfizer Inc. Inhibiteurs de l'enzyme integrase du vih
CA2563761C (fr) 2004-04-26 2009-12-29 Pfizer Inc. Inhibiteurs de l'enzyme integrase du vih

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU34997B (en) * 1970-03-27 1980-06-30 Hiroyuki Tawada Process for preparing benzodiazepine derivatives
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs

Also Published As

Publication number Publication date
EP0949926A4 (fr) 2001-01-17
EP0949926A1 (fr) 1999-10-20
AU4917397A (en) 1998-05-22
WO1998018473A1 (fr) 1998-05-07

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued