CA2268945A1 - Compositions amphiphiles cationiques destinees a un apport intracellulaire de molecules therapeutiques - Google Patents

Compositions amphiphiles cationiques destinees a un apport intracellulaire de molecules therapeutiques Download PDF

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Publication number
CA2268945A1
CA2268945A1 CA002268945A CA2268945A CA2268945A1 CA 2268945 A1 CA2268945 A1 CA 2268945A1 CA 002268945 A CA002268945 A CA 002268945A CA 2268945 A CA2268945 A CA 2268945A CA 2268945 A1 CA2268945 A1 CA 2268945A1
Authority
CA
Canada
Prior art keywords
amphiphiles
amphiphile
cationic
carbamate
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002268945A
Other languages
English (en)
Inventor
John Marshall
David J. Harris
Edward R. Lee
Craig S. Siegel
Simon J. Eastman
Chau Dung Chang
Ronald K. Scheule
Seng H. Cheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2268945A1 publication Critical patent/CA2268945A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouveaux amphiphiles cationiques facilitant le transport de molécules (thérapeutiques) biologiquement actives dans des cellules. Selon cette invention, un tel amphiphile cationique est utilisé dans un état dans lequel il est capable d'accepter des protons supplémentaires, c'est-à-dire qu'il n'est pas entièrement saturé en protons. Dans le cadre de cette invention, les amphiphiles cationiques peuvent être regroupés en quatre catégories générales: (A) amphiphiles en T/stéroïdiens; (B) amphiphiles en T/ non stéroïdiens; (C) amphiphiles n'étant pas en T/ stéroïdiens, et (D) amphiphiles n'étant pas en T/ non stéroïdiens.
CA002268945A 1997-06-10 1997-06-10 Compositions amphiphiles cationiques destinees a un apport intracellulaire de molecules therapeutiques Abandoned CA2268945A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1997/009748 WO1998013026A1 (fr) 1997-06-10 1997-06-10 Compositions amphiphiles cationiques destinees a un apport intracellulaire de molecules therapeutiques

Publications (1)

Publication Number Publication Date
CA2268945A1 true CA2268945A1 (fr) 1998-04-02

Family

ID=22261030

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002268945A Abandoned CA2268945A1 (fr) 1997-06-10 1997-06-10 Compositions amphiphiles cationiques destinees a un apport intracellulaire de molecules therapeutiques

Country Status (4)

Country Link
EP (1) EP1007003A1 (fr)
JP (1) JP2001500897A (fr)
CA (1) CA2268945A1 (fr)
WO (1) WO1998013026A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999052858A2 (fr) * 1998-04-08 1999-10-21 Celltech Therapeutics Limited Lipides
AUPQ259399A0 (en) 1999-09-01 1999-09-23 Lustre Investments Pte Ltd Therapeutic agents
IL150027A0 (en) * 1999-12-04 2002-12-01 Res Dev Foundation Carbon dioxide enhancement of inhalation therapy
FR2825364A1 (fr) * 2001-05-29 2002-12-06 Genethon Iii Vecteur peptiidique pour le transfert d'acides nucleiques dans des cellules eucaryotes
KR100882706B1 (ko) * 2002-07-29 2009-02-06 제이에스알 가부시끼가이샤 디아민 화합물, 폴리아믹산, 이미드화 중합체, 액정배향제 및 액정표시소자

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62209523A (ja) * 1986-03-11 1987-09-14 Fuji Photo Film Co Ltd 感光材料
US5283185A (en) * 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells

Also Published As

Publication number Publication date
WO1998013026A1 (fr) 1998-04-02
JP2001500897A (ja) 2001-01-23
EP1007003A1 (fr) 2000-06-14

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead