CA2268007A1 - Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire - Google Patents
Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire Download PDFInfo
- Publication number
- CA2268007A1 CA2268007A1 CA002268007A CA2268007A CA2268007A1 CA 2268007 A1 CA2268007 A1 CA 2268007A1 CA 002268007 A CA002268007 A CA 002268007A CA 2268007 A CA2268007 A CA 2268007A CA 2268007 A1 CA2268007 A1 CA 2268007A1
- Authority
- CA
- Canada
- Prior art keywords
- amino acid
- polypeptide
- bait
- seq
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
L'invention concerne une nouvelle protéine de l'inhibiteur cérébro-associé de l'activateur du plasminogène de type tissulaire (BAIT), laquelle est un membre de la superfamille des serpines, qui s'exprime généralement dans le tissu du cerveau. L'invention concerne notamment des molécules d'acides nucléiques isolées codant la protéine humaine BAIT. On décrit également des polypeptides BAIT en tant que vecteurs et cellules hôtes, ainsi que des procédés de recombinaison aux fins de production de ceux-ci. L'invention concerne encore des procédés de criblage destinés à l'identification des agonistes et antagonistes de l'activité de BAIT, des procédés de diagnostic destinés à détecter des troubles associés au système nerveux, de même que des procédés thérapeutiques destinés au traitement de troubles associés au système nerveux.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1996/016484 WO1998016643A1 (fr) | 1996-10-11 | 1996-10-11 | Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2268007A1 true CA2268007A1 (fr) | 1998-04-23 |
Family
ID=22255955
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002268007A Abandoned CA2268007A1 (fr) | 1996-10-11 | 1996-10-11 | Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0934410A1 (fr) |
JP (1) | JP2002501365A (fr) |
AU (1) | AU7431796A (fr) |
CA (1) | CA2268007A1 (fr) |
WO (1) | WO1998016643A1 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7235529B2 (en) | 1996-10-11 | 2007-06-26 | Human Genome Sciences, Inc. | Brain-associated inhibitor of tissue-type plasminogen activator |
WO1999041381A1 (fr) * | 1998-02-13 | 1999-08-19 | Peter Sonderegger | Neuroserpine |
WO2000053793A1 (fr) | 1999-03-10 | 2000-09-14 | Human Genome Sciences, Inc. | Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire |
WO2000065349A2 (fr) * | 1999-04-28 | 2000-11-02 | Cardiogenics Inc. | Procede de determination d'inhibiteur d'un activateur de plasminogene |
GB0217033D0 (en) | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
GB0217434D0 (en) | 2002-07-27 | 2002-09-04 | Royal Vetinary College | Biological material |
GB0315323D0 (en) | 2003-07-01 | 2003-08-06 | Royal Veterinary College | Vaccine composition |
US9023366B2 (en) | 2003-07-01 | 2015-05-05 | The Royal Veterinary College | Vaccine composition for vaccinating dogs against canine infectious respiratory disease (CIRD) |
EP2513146B1 (fr) | 2009-12-18 | 2017-05-03 | Kancera AB | Anticorps contre ror1 induisant la mort cellulaire de cellules cll |
GB201020995D0 (en) | 2010-12-10 | 2011-01-26 | Bioinvent Int Ab | Biological materials and uses thereof |
GB201219678D0 (en) | 2012-11-01 | 2012-12-12 | Benf Ab | Ketone body inhibitors and uses thereof |
CN105026419B (zh) | 2013-03-01 | 2021-08-24 | 勃林格殷格翰动物保健美国有限公司 | 疫苗组合物定量 |
GB201320679D0 (en) | 2013-11-22 | 2014-01-08 | Univ Nottingham | Polypeptides,polynucleotides and uses thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5700924A (en) * | 1995-06-07 | 1997-12-23 | Incyte Pharmaceuticals, Inc. | Serpin derived from human hypothalamus |
-
1996
- 1996-10-11 AU AU74317/96A patent/AU7431796A/en not_active Abandoned
- 1996-10-11 CA CA002268007A patent/CA2268007A1/fr not_active Abandoned
- 1996-10-11 EP EP96936500A patent/EP0934410A1/fr not_active Ceased
- 1996-10-11 JP JP51829398A patent/JP2002501365A/ja not_active Withdrawn
- 1996-10-11 WO PCT/US1996/016484 patent/WO1998016643A1/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2002501365A (ja) | 2002-01-15 |
AU7431796A (en) | 1998-05-11 |
EP0934410A1 (fr) | 1999-08-11 |
WO1998016643A1 (fr) | 1998-04-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |