CA2268007A1 - Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire - Google Patents

Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire Download PDF

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Publication number
CA2268007A1
CA2268007A1 CA002268007A CA2268007A CA2268007A1 CA 2268007 A1 CA2268007 A1 CA 2268007A1 CA 002268007 A CA002268007 A CA 002268007A CA 2268007 A CA2268007 A CA 2268007A CA 2268007 A1 CA2268007 A1 CA 2268007A1
Authority
CA
Canada
Prior art keywords
amino acid
polypeptide
bait
seq
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002268007A
Other languages
English (en)
Inventor
Gregg A. Hastings
Daniel A. Lawrence
Timothy A. Coleman
Patrick J. Dillon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American National Red Cross
Human Genome Sciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2268007A1 publication Critical patent/CA2268007A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne une nouvelle protéine de l'inhibiteur cérébro-associé de l'activateur du plasminogène de type tissulaire (BAIT), laquelle est un membre de la superfamille des serpines, qui s'exprime généralement dans le tissu du cerveau. L'invention concerne notamment des molécules d'acides nucléiques isolées codant la protéine humaine BAIT. On décrit également des polypeptides BAIT en tant que vecteurs et cellules hôtes, ainsi que des procédés de recombinaison aux fins de production de ceux-ci. L'invention concerne encore des procédés de criblage destinés à l'identification des agonistes et antagonistes de l'activité de BAIT, des procédés de diagnostic destinés à détecter des troubles associés au système nerveux, de même que des procédés thérapeutiques destinés au traitement de troubles associés au système nerveux.
CA002268007A 1996-10-11 1996-10-11 Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire Abandoned CA2268007A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1996/016484 WO1998016643A1 (fr) 1996-10-11 1996-10-11 Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire

Publications (1)

Publication Number Publication Date
CA2268007A1 true CA2268007A1 (fr) 1998-04-23

Family

ID=22255955

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002268007A Abandoned CA2268007A1 (fr) 1996-10-11 1996-10-11 Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire

Country Status (5)

Country Link
EP (1) EP0934410A1 (fr)
JP (1) JP2002501365A (fr)
AU (1) AU7431796A (fr)
CA (1) CA2268007A1 (fr)
WO (1) WO1998016643A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7235529B2 (en) 1996-10-11 2007-06-26 Human Genome Sciences, Inc. Brain-associated inhibitor of tissue-type plasminogen activator
WO1999041381A1 (fr) * 1998-02-13 1999-08-19 Peter Sonderegger Neuroserpine
WO2000053793A1 (fr) 1999-03-10 2000-09-14 Human Genome Sciences, Inc. Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire
WO2000065349A2 (fr) * 1999-04-28 2000-11-02 Cardiogenics Inc. Procede de determination d'inhibiteur d'un activateur de plasminogene
GB0217033D0 (en) 2002-07-23 2002-08-28 Delta Biotechnology Ltd Gene and polypeptide sequences
GB0217434D0 (en) 2002-07-27 2002-09-04 Royal Vetinary College Biological material
GB0315323D0 (en) 2003-07-01 2003-08-06 Royal Veterinary College Vaccine composition
US9023366B2 (en) 2003-07-01 2015-05-05 The Royal Veterinary College Vaccine composition for vaccinating dogs against canine infectious respiratory disease (CIRD)
EP2513146B1 (fr) 2009-12-18 2017-05-03 Kancera AB Anticorps contre ror1 induisant la mort cellulaire de cellules cll
GB201020995D0 (en) 2010-12-10 2011-01-26 Bioinvent Int Ab Biological materials and uses thereof
GB201219678D0 (en) 2012-11-01 2012-12-12 Benf Ab Ketone body inhibitors and uses thereof
CN105026419B (zh) 2013-03-01 2021-08-24 勃林格殷格翰动物保健美国有限公司 疫苗组合物定量
GB201320679D0 (en) 2013-11-22 2014-01-08 Univ Nottingham Polypeptides,polynucleotides and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700924A (en) * 1995-06-07 1997-12-23 Incyte Pharmaceuticals, Inc. Serpin derived from human hypothalamus

Also Published As

Publication number Publication date
JP2002501365A (ja) 2002-01-15
AU7431796A (en) 1998-05-11
EP0934410A1 (fr) 1999-08-11
WO1998016643A1 (fr) 1998-04-23

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead