CA2267977A1 - Cytokine enhanced immunotherapy for brain tumors - Google Patents

Cytokine enhanced immunotherapy for brain tumors Download PDF

Info

Publication number
CA2267977A1
CA2267977A1 CA002267977A CA2267977A CA2267977A1 CA 2267977 A1 CA2267977 A1 CA 2267977A1 CA 002267977 A CA002267977 A CA 002267977A CA 2267977 A CA2267977 A CA 2267977A CA 2267977 A1 CA2267977 A1 CA 2267977A1
Authority
CA
Canada
Prior art keywords
cytokine
tumor
cells
csf
days
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002267977A
Other languages
English (en)
French (fr)
Inventor
Matthew G. Ewend
Reid C. Thompson
Elizabeth M. Jaffee
Kam W. Leong
Henry Brem
Drew M. Pardoll
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2267977A1 publication Critical patent/CA2267977A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0085Brain, e.g. brain implants; Spinal cord
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002267977A 1996-10-16 1997-10-15 Cytokine enhanced immunotherapy for brain tumors Abandoned CA2267977A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73159796A 1996-10-16 1996-10-16
US08/731597 1996-10-16
PCT/US1997/018455 WO1998016246A1 (en) 1996-10-16 1997-10-15 Cytokine enhanced immunotherapy for brain tumors

Publications (1)

Publication Number Publication Date
CA2267977A1 true CA2267977A1 (en) 1998-04-23

Family

ID=24940192

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002267977A Abandoned CA2267977A1 (en) 1996-10-16 1997-10-15 Cytokine enhanced immunotherapy for brain tumors

Country Status (5)

Country Link
EP (1) EP0930892A1 (de)
JP (1) JP2001502331A (de)
AU (1) AU4818297A (de)
CA (1) CA2267977A1 (de)
WO (1) WO1998016246A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995016464A1 (en) * 1993-12-14 1995-06-22 Johns Hopkins University School Of Medicine Controlled release of pharmaceutically active substances for immunotherapy
US6277368B1 (en) 1996-07-25 2001-08-21 The Regents Of The University Of California Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine
ATE412418T1 (de) * 1998-04-02 2008-11-15 Univ California Zusammensetzungen zur erhöhung der zahl antigen präsentierender zellen und der antitumoralen antwort in menschlichen patienten
US20010043914A1 (en) * 1999-12-28 2001-11-22 Edith Mathiowitz Methods and products for tumor immunotherapy
CN1270775C (zh) * 2000-06-29 2006-08-23 默克专利有限公司 通过与免疫细胞因子摄入促进剂联合治疗来增强抗体-细胞因子融合蛋白介导的免疫反应
US6911204B2 (en) 2000-08-11 2005-06-28 Favrille, Inc. Method and composition for altering a B cell mediated pathology
CA2479528A1 (en) * 2002-03-25 2003-10-02 Technologies Biolactis Inc. Chemotherapeutic agents as anti-cancer vaccine adjuvants and therapeutic methods thereof
EP1374893A1 (de) 2002-06-17 2004-01-02 NovImmune S.A. Impfung mit Immuno-isolierten Zellen die einen Immunomodulator Produzieren
US7695723B2 (en) * 2002-12-31 2010-04-13 Sygnis Bioscience Gmbh & Co. Kg Methods of treating neurological conditions with hematopoietic growth factors
JP7410472B2 (ja) 2015-09-25 2024-01-10 リリース セラピューティクス エスアー 免疫調節物質を産生する免疫隔離細胞とのワクチン接種
US20220403001A1 (en) 2018-06-12 2022-12-22 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
US20220056092A1 (en) 2018-12-11 2022-02-24 Obsidian Therapeutics, Inc. Membrane bound il12 compositions and methods for tunable regulation
CA3132840A1 (en) 2019-03-08 2020-09-17 Obsidian Therapeutics, Inc. Human carbonic anhydrase 2 compositions and methods for tunable regulation
AU2020290522A1 (en) 2019-06-12 2022-01-20 Obsidian Therapeutics, Inc. CA2 compositions and methods for tunable regulation
US20220267398A1 (en) 2019-06-12 2022-08-25 Obsidian Therapeutics, Inc. Ca2 compositions and methods for tunable regulation
WO2021040736A1 (en) 2019-08-30 2021-03-04 Obsidian Therapeutics, Inc. Tandem cd19 car-based compositions and methods for immunotherapy
MX2022002747A (es) 2019-09-10 2022-04-06 Obsidian Therapeutics Inc Proteinas de fusion de ca2-il15 para regulacion ajustable.

Also Published As

Publication number Publication date
WO1998016246A1 (en) 1998-04-23
AU4818297A (en) 1998-05-11
JP2001502331A (ja) 2001-02-20
EP0930892A1 (de) 1999-07-28

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued