CA2264297A1 - Composes pharmaceutiques - Google Patents

Composes pharmaceutiques Download PDF

Info

Publication number
CA2264297A1
CA2264297A1 CA002264297A CA2264297A CA2264297A1 CA 2264297 A1 CA2264297 A1 CA 2264297A1 CA 002264297 A CA002264297 A CA 002264297A CA 2264297 A CA2264297 A CA 2264297A CA 2264297 A1 CA2264297 A1 CA 2264297A1
Authority
CA
Canada
Prior art keywords
group
alkyl
hydrogen
compound
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002264297A
Other languages
English (en)
Inventor
Chuan Shih
Joseph Michael Gruber
Cora Sue Grossman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Hawaii
Wayne State University
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2264297A1 publication Critical patent/CA2264297A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne de nouveaux composés de cryptophycine, lesquels peuvent être utiles pour interrompre le système de la microtubuline en tant qu'agents anti-néoplasiques et dans le traitement du cancer. L'invention concerne également une formulation destinée à l'administration des nouveaux composés de cryptophycine.
CA002264297A 1996-08-30 1997-08-28 Composes pharmaceutiques Abandoned CA2264297A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2507896P 1996-08-30 1996-08-30
US60/025,078 1996-08-30
PCT/US1997/015236 WO1998008829A1 (fr) 1996-08-30 1997-08-28 Composes pharmaceutiques

Publications (1)

Publication Number Publication Date
CA2264297A1 true CA2264297A1 (fr) 1998-03-05

Family

ID=21823932

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002264297A Abandoned CA2264297A1 (fr) 1996-08-30 1997-08-28 Composes pharmaceutiques

Country Status (5)

Country Link
EP (1) EP0923564A4 (fr)
JP (1) JP2001500853A (fr)
AU (1) AU4169897A (fr)
CA (1) CA2264297A1 (fr)
WO (1) WO1998008829A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69626544T2 (de) * 1995-12-22 2004-01-15 Lilly Co Eli Arzneistoffe
JP2001500484A (ja) * 1996-08-30 2001-01-16 イーライ・リリー・アンド・カンパニー 医薬化合物の製造法
WO1998009974A1 (fr) * 1996-09-06 1998-03-12 Eli Lilly And Company Procede et nouveaux intermediaires
PL335478A1 (en) * 1997-02-26 2000-04-25 Lilly Co Eli Method of obtaining pharmaceutic compounds
US6103913A (en) * 1998-10-16 2000-08-15 Eli Lilly And Company Process for preparing enollactone derivatives
US6376230B1 (en) 1998-10-16 2002-04-23 Eli Lilly And Company Stereoselective process for producing intermediates of cryptophycins
DE19913995A1 (de) 1999-03-29 2000-10-05 Basf Ag Verfahren zur Herstellung von körnigen N-Alkylamoniumacetonitril-Salzen
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946835A (en) * 1988-07-15 1990-08-07 Merck & Co., Inc. Antifungal fermentation product and method
US4845085A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
US4845086A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent

Also Published As

Publication number Publication date
EP0923564A4 (fr) 1999-12-08
WO1998008829A1 (fr) 1998-03-05
JP2001500853A (ja) 2001-01-23
AU4169897A (en) 1998-03-19
EP0923564A1 (fr) 1999-06-23

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Legal Events

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FZDE Dead