CA2263671A1 - Polymer bile acid resorption inhibitors with simultaneous bile acid adsorbing effect - Google Patents
Polymer bile acid resorption inhibitors with simultaneous bile acid adsorbing effect Download PDFInfo
- Publication number
- CA2263671A1 CA2263671A1 CA002263671A CA2263671A CA2263671A1 CA 2263671 A1 CA2263671 A1 CA 2263671A1 CA 002263671 A CA002263671 A CA 002263671A CA 2263671 A CA2263671 A CA 2263671A CA 2263671 A1 CA2263671 A1 CA 2263671A1
- Authority
- CA
- Canada
- Prior art keywords
- alkylene
- nr9r10
- alkyl
- compounds
- nhr9
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F246/00—Copolymers in which the nature of only the monomers in minority is defined
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19633268.0 | 1996-08-19 | ||
| DE19633268A DE19633268A1 (de) | 1996-08-19 | 1996-08-19 | Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung |
| PCT/EP1997/004049 WO1998007449A2 (de) | 1996-08-19 | 1997-07-25 | Polymere gallensäure-resorptionsinhibitoren mit gleichzeitiger gallensäure-adsorberwirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2263671A1 true CA2263671A1 (en) | 1998-02-26 |
Family
ID=7802940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002263671A Abandoned CA2263671A1 (en) | 1996-08-19 | 1997-07-25 | Polymer bile acid resorption inhibitors with simultaneous bile acid adsorbing effect |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0918544A2 (de) |
| JP (1) | JP2000517356A (de) |
| CA (1) | CA2263671A1 (de) |
| DE (1) | DE19633268A1 (de) |
| WO (1) | WO1998007449A2 (de) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11685835B2 (en) | 2016-05-11 | 2023-06-27 | Sony Corporation | Ultra bright dimeric or polymeric dyes |
| US11827661B2 (en) | 2015-02-26 | 2023-11-28 | Sony Group Corporation | Water soluble fluorescent or colored dyes comprising conjugating groups |
| US11874280B2 (en) | 2018-03-19 | 2024-01-16 | Sony Group Corporation | Use of divalent metals for enhancement of fluorescent signals |
| US11931419B2 (en) | 2017-11-16 | 2024-03-19 | Sony Group Corporation | Programmable polymeric drugs |
| US11939474B2 (en) | 2013-08-22 | 2024-03-26 | Sony Group Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| US11945955B2 (en) | 2019-09-26 | 2024-04-02 | Sony Group Corporation | Polymeric tandem dyes with linker groups |
| US11981820B2 (en) | 2016-04-01 | 2024-05-14 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes |
| US12006438B2 (en) | 2019-06-27 | 2024-06-11 | Sony Group Corporation | Polymeric dyes with linker groups comprising deoxyribose |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3942846B2 (ja) | 2001-06-21 | 2007-07-11 | 独立行政法人科学技術振興機構 | 組織特異的トランスポーター阻害剤 |
| AU2003301324A1 (en) * | 2002-10-16 | 2004-05-04 | Kyowa Medex Co., Ltd. | Method and reagent for measuring cholesterol in high-density lipoproteins |
| PL2637646T3 (pl) | 2010-11-08 | 2017-01-31 | Albireo Ab | Kombinacja farmaceutyczna zawierająca inhibitor ibat i środek wiążący kwasy żółciowe |
| AU2011326871B2 (en) | 2010-11-08 | 2015-02-12 | Albireo Ab | IBAT inhibitors for the treatment of liver diseases |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| WO2015199147A1 (ja) | 2014-06-25 | 2015-12-30 | 味の素株式会社 | 固形製剤及びその着色防止又は着色低減方法 |
| EP3012252A1 (de) | 2014-10-24 | 2016-04-27 | Ferring BV | Kristalline Form von elobixibat |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| WO2017138877A1 (en) | 2016-02-09 | 2017-08-17 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| ES2874546T3 (es) | 2016-02-09 | 2021-11-05 | Albireo Ab | Formulación oral de colestiramina y uso de la misma |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| CA3071182A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | Cholestyramine pellets, oral cholestyramine formulations and use thereof |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| US20210128591A1 (en) * | 2017-12-13 | 2021-05-06 | Sony Corporation | Ionic polymers comprising biologically active compounds |
| CN112449637B (zh) | 2018-06-05 | 2024-03-19 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| MX2020013774A (es) | 2018-06-20 | 2021-03-02 | Albireo Ab | Modificaciones de cristales de odevixibat. |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| CA3127408A1 (en) | 2019-02-06 | 2020-08-13 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| PT3921028T (pt) | 2019-02-06 | 2023-02-15 | Albireo Ab | Compostos de benzotiadiazepina e a sua utilização como moduladores de ácido biliar |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| CA3158276A1 (en) | 2019-12-04 | 2021-06-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
| EP4069361B1 (de) | 2019-12-04 | 2024-01-03 | Albireo AB | Benzothia(di)azepinverbindungen und ihre verwendung als gallensäuremodulatoren |
| BR112022010505A2 (pt) | 2019-12-04 | 2022-09-06 | Albireo Ab | Compostos de benzotia(di)azepina e seu uso como moduladores do ácido biliar |
| AR120676A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como ácido biliar |
| AR120679A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores ácido biliar |
| AR120682A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiadiazepina y su uso como moduladores del ácido biliar |
| EP4069247A1 (de) | 2019-12-04 | 2022-10-12 | Albireo AB | Benzothiadiazepinverbindungen und ihre verwendung als gallensäuremodulatoren |
| AR120674A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiazepina y su uso como ácido biliar |
| TW202134222A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯化合物及其作為膽酸調節劑之用途 |
| CN116157389A (zh) | 2020-08-03 | 2023-05-23 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| CA3196488A1 (en) | 2020-11-12 | 2022-05-19 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| AU2021390172A1 (en) | 2020-12-04 | 2023-06-22 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US20230398125A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3572985D1 (en) * | 1984-05-11 | 1989-10-19 | Bristol Myers Co | Novel bile sequestrant resin and uses |
| ES2096614T3 (es) * | 1990-12-06 | 1997-03-16 | Hoechst Ag | Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de este compuesto como medicamento. |
| FI108451B (fi) * | 1991-12-20 | 2002-01-31 | Hoechst Ag | Menetelmõ polymeeristen ja oligomeeristen sappihappojohdannaisten valmistamiseksi |
| NZ245504A (en) * | 1991-12-20 | 1995-08-28 | Hoechst Ag | Bile acid derivatives containing an ethylenically unsaturated grouping |
| EP0580078B1 (de) * | 1992-07-22 | 1997-10-15 | Hoechst Aktiengesellschaft | Hydrophile Zentren aufweisende Polyvinylamin-Derivate, Verfahren zu ihrer Herstellung sowie die Verwendung der Verbindungen als Arzneimittel, Wirkstoffträger und Nahrungsmittelhilfsstoff |
| EP0580079B1 (de) * | 1992-07-22 | 1996-12-11 | Hoechst Aktiengesellschaft | Vernetzte, stickstoffhaltige Vinylcopolymere, Verfahren zu ihrer Herstellung sowie die Verwendung dieser Verbindungen |
| DE4234537A1 (de) * | 1992-10-14 | 1994-04-21 | Hoechst Ag | Zubereitung, enthaltend Insulin und polymere Gallensäure |
| JPH06321785A (ja) * | 1993-05-12 | 1994-11-22 | Sekisui Chem Co Ltd | 胆汁酸腸管吸収抑制剤 |
| JPH06329543A (ja) * | 1993-05-20 | 1994-11-29 | Sekisui Chem Co Ltd | 経口コレステロール低下剤 |
| US5607669A (en) * | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
-
1996
- 1996-08-19 DE DE19633268A patent/DE19633268A1/de not_active Withdrawn
-
1997
- 1997-07-25 CA CA002263671A patent/CA2263671A1/en not_active Abandoned
- 1997-07-25 JP JP10510319A patent/JP2000517356A/ja active Pending
- 1997-07-25 WO PCT/EP1997/004049 patent/WO1998007449A2/de not_active Application Discontinuation
- 1997-07-25 EP EP97940028A patent/EP0918544A2/de not_active Withdrawn
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11939474B2 (en) | 2013-08-22 | 2024-03-26 | Sony Group Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| US11827661B2 (en) | 2015-02-26 | 2023-11-28 | Sony Group Corporation | Water soluble fluorescent or colored dyes comprising conjugating groups |
| US11981820B2 (en) | 2016-04-01 | 2024-05-14 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes |
| US11685835B2 (en) | 2016-05-11 | 2023-06-27 | Sony Corporation | Ultra bright dimeric or polymeric dyes |
| US11931419B2 (en) | 2017-11-16 | 2024-03-19 | Sony Group Corporation | Programmable polymeric drugs |
| US11874280B2 (en) | 2018-03-19 | 2024-01-16 | Sony Group Corporation | Use of divalent metals for enhancement of fluorescent signals |
| US12006438B2 (en) | 2019-06-27 | 2024-06-11 | Sony Group Corporation | Polymeric dyes with linker groups comprising deoxyribose |
| US11945955B2 (en) | 2019-09-26 | 2024-04-02 | Sony Group Corporation | Polymeric tandem dyes with linker groups |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998007449A2 (de) | 1998-02-26 |
| JP2000517356A (ja) | 2000-12-26 |
| WO1998007449A3 (de) | 1998-06-25 |
| EP0918544A2 (de) | 1999-06-02 |
| DE19633268A1 (de) | 1998-02-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2263671A1 (en) | Polymer bile acid resorption inhibitors with simultaneous bile acid adsorbing effect | |
| JP6247740B2 (ja) | 胆汁酸捕捉剤として使用するための架橋されたポリビニルアミン、ポリアリルアミンおよびポリエチレンイミン | |
| KR100271693B1 (ko) | 환자 체내로부터 담즙염을 제거하기 위한 방법 및 이 방법에 사용되는 알킬화된 조성물 | |
| EP0622078B1 (de) | Cholesterinspiegelsenkendes mittel | |
| JP4499363B2 (ja) | 血清グルコースの減少方法 | |
| CA2303447C (en) | Cationic polymers as toxin-binding agents | |
| JPH0625354A (ja) | 胆汁酸誘導体のポリマー及びオリゴマー、その製造方法及び医薬としてのその使用 | |
| CN103145932A (zh) | 一种长循环抗肿瘤靶向药物载体及其制备方法 | |
| CA2281602A1 (en) | Cross-linked vinyl polymers with bile acid adsorbing effect | |
| US5114709A (en) | Ferric ion coordinated polyamine resins for the lowering of blood cholesterol | |
| CA2063499C (en) | Ingestible polymeric phosphonium salts for the lowering of blood cholesterol | |
| MXPA99001725A (en) | Polymer bile acid resorption inhibitors with simultaneous bile acid adsorbing effect | |
| Thale et al. | Binding of bile acids to anion-exchanging drugs in vitro | |
| CA1335142C (en) | Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol | |
| DE19748659A1 (de) | Aminophosphoniumgruppen enthaltende vernetzte Copolymere für medizinische Verwendungen | |
| JP2003147025A (ja) | 胆汁酸特異的認識ポリマー及びコレステロール低下剤 | |
| DE19748712A1 (de) | Aminophosphoniumgruppen enthaltende Polymere | |
| MXPA99007600A (en) | Cross-linked vinyl polymers with bile acid adsorbing effect | |
| CN104337767A (zh) | 一种pH敏感性药物载体胶束的制备方法 | |
| Zhu et al. | Polymeric Sorbents for Bile Acids: II. Oligopeptide-Containing Resins with Quaternary Amine Groups | |
| JPWO2021084087A5 (de) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |