CA2260774A1 - Substituted triazolo-pyridazine derivatives as ligands for gaba receptors - Google Patents
Substituted triazolo-pyridazine derivatives as ligands for gaba receptorsInfo
- Publication number
- CA2260774A1 CA2260774A1 CA002260774A CA2260774A CA2260774A1 CA 2260774 A1 CA2260774 A1 CA 2260774A1 CA 002260774 A CA002260774 A CA 002260774A CA 2260774 A CA2260774 A CA 2260774A CA 2260774 A1 CA2260774 A1 CA 2260774A1
- Authority
- CA
- Canada
- Prior art keywords
- ligands
- pyridazine derivatives
- gaba receptors
- substituted
- substituted triazolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003446 ligand Substances 0.000 title abstract 2
- CBHTTYDJRXOHHL-UHFFFAOYSA-N 2h-triazolo[4,5-c]pyridazine Chemical class N1=NC=CC2=C1N=NN2 CBHTTYDJRXOHHL-UHFFFAOYSA-N 0.000 title 1
- 102000005915 GABA Receptors Human genes 0.000 title 1
- 108010005551 GABA Receptors Proteins 0.000 title 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 102000004300 GABA-A Receptors Human genes 0.000 abstract 1
- 108090000839 GABA-A Receptors Proteins 0.000 abstract 1
- YRACHDVMKITFAZ-UHFFFAOYSA-N [1,2,4]triazolo[4,3-b]pyridazine Chemical class C1=CC=NN2C=NN=C21 YRACHDVMKITFAZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000036461 convulsion Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Abstract
A class of substituted or 7,8-ring fused 1,2,4triazolo[4,3-b]pyridazine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and a substituted alkoxy moiety at the 6-position, are selective ligands for GABA A
receptors, in particular having high affinity for the a2 and/or 0 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
receptors, in particular having high affinity for the a2 and/or 0 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9615645.0A GB9615645D0 (en) | 1996-07-25 | 1996-07-25 | Therapeutic agents |
| GBGB9625397.6A GB9625397D0 (en) | 1996-12-06 | 1996-12-06 | Therapeutic agents |
| GB9714420.8 | 1997-07-09 | ||
| GB9625397.6 | 1997-07-09 | ||
| GB9615645.0 | 1997-07-09 | ||
| GBGB9714420.8A GB9714420D0 (en) | 1997-07-09 | 1997-07-09 | Therapeutic agents |
| PCT/GB1997/001946 WO1998004559A2 (en) | 1996-07-25 | 1997-07-17 | Substituted triazolo-pyridazine derivatives as ligands for gaba receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2260774A1 true CA2260774A1 (en) | 1998-02-05 |
| CA2260774C CA2260774C (en) | 2007-07-03 |
Family
ID=38280590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002260774A Expired - Fee Related CA2260774C (en) | 1996-07-25 | 1997-07-17 | Substituted triazolo-pyridazine derivatives as ligands for gaba receptors |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2260774C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113009014A (en) * | 2021-02-24 | 2021-06-22 | 上海旭东海普药业有限公司 | High performance liquid detection method for 2-methoxy-5-fluorouracil impurity |
-
1997
- 1997-07-17 CA CA002260774A patent/CA2260774C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113009014A (en) * | 2021-02-24 | 2021-06-22 | 上海旭东海普药业有限公司 | High performance liquid detection method for 2-methoxy-5-fluorouracil impurity |
| CN113009014B (en) * | 2021-02-24 | 2023-04-07 | 上海旭东海普药业有限公司 | High performance liquid detection method for 2-methoxy-5-fluorouracil impurities |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2260774C (en) | 2007-07-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2359008A1 (en) | Triazolo-pyridazine derivatives as ligands for gaba receptors | |
| BG104671A (en) | Triazolo-pyridazine derivatives as ligands for gaba receptors | |
| TR199900047T2 (en) | Substituted triazolo-pyridazine derivatives as ligands of Gaba receptors | |
| AU2001270297A1 (en) | 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands | |
| GB9927687D0 (en) | Therapeutic agents | |
| GR3036669T3 (en) | O-carbamoyl-phenylalaninol having substituent at benzene ring, its pharmaceutically useful salts and method for preparing the same | |
| AU6230098A (en) | Isoquinolinone derivatives, process for preparing the same, and their use as phosphodiesterase inhibitors | |
| GB9801208D0 (en) | Therapeutic agents | |
| AU2218997A (en) | Certain fused pyrrolecarboxamides as gaba brain receptor ligands | |
| GB0117277D0 (en) | Therapeutic agents | |
| GB9919957D0 (en) | Therapeutic agents | |
| BG105152A (en) | A substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom | |
| SG46741A1 (en) | Pyridazinone derivatives and processes for preparing the same | |
| AU2253297A (en) | Imidazo{1,2-a}pyridine c-nucleosides as antiviral agents | |
| DK0693070T3 (en) | Pyrido [2,3-b] [1,4] benzodiazepinones as M2 receptor ligand for the treatment of neurological disorders | |
| AU2403195A (en) | Tryptamine derivatives as 5-ht-1d receptor ligands | |
| CA2260774A1 (en) | Substituted triazolo-pyridazine derivatives as ligands for gaba receptors | |
| DK0935598T3 (en) | 5-heteroatom-alkyl-substituted 3-oxopyrido (1,2-a) benzimidazole-4-carboxamide derivatives suitable for the treatment of central nervous system disorders | |
| AU2525095A (en) | Method for the preparation of 9-amino camptothecin | |
| CY2392B1 (en) | Method for the preparation of alpha-bromolactam derivatives. | |
| AU1054500A (en) | N-substituted (3,6-dihydro)-2h-1,2-oxazine derivatives, their preparation and their use as selective mglur1 antagonists | |
| AU3764795A (en) | Pyrido{3,4-b}indole carboxamide derivatives as serotonergic agents | |
| HU0003979D0 (en) | Process for the preparation of 3-pyridylsulphonil-pyrazolo[4,3-d] pyrimidin-7-one derivatives and intermediates thereof | |
| AU5450798A (en) | Novel 1,2,4-triazolo{4,3-c}quinazolin-3-ones and 1,2,4-triazolo{4,3-c}quinazolin-3-thiones; a new class of gaba brain receptor ligands | |
| GB2316072B (en) | Pyrrolo[3,2-c]quinoline derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150717 |