CA2250258A1 - Novel tetralone or benzopyranone derivatives and process for producing the same - Google Patents
Novel tetralone or benzopyranone derivatives and process for producing the sameInfo
- Publication number
- CA2250258A1 CA2250258A1 CA002250258A CA2250258A CA2250258A1 CA 2250258 A1 CA2250258 A1 CA 2250258A1 CA 002250258 A CA002250258 A CA 002250258A CA 2250258 A CA2250258 A CA 2250258A CA 2250258 A1 CA2250258 A1 CA 2250258A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- benzopyranone
- tetralone
- producing
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XHLHPRDBBAGVEG-UHFFFAOYSA-N 1-tetralone Chemical compound C1=CC=C2C(=O)CCCC2=C1 XHLHPRDBBAGVEG-UHFFFAOYSA-N 0.000 title abstract 4
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical class C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 title abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 2
- -1 benzopyranone compound Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzenecarboxaldehyde Natural products O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Abstract
The present invention provides new tetralone or benzopyranone derivatives and a method for producing the derivatives useful for a therapeutic agent for preventing and/or treating hormone dependent diseases.
The present invention is a new tetralone or benzopyranone derivative represented by a particular general formula (I) (see formula I) wherein R1 represents a hydroxy group, an alkyloxy group or an aralkyloxy group, R2-R6 represent hydrogen, a hydroxy group, a straight or branched alkyloxy or aralkyloxy group having 1-6 carbon atoms, a halogen, an amino group or an alkylene dioxy group joined at R2 and R3, R3 and R4, R4 and R5, R5 and R6, and A represents a methylene or oxygen, but provided that when R1 is methoxy, R2-R6 are all hydrogens and A is the methylene.
In the production, a particular tetralone or benzopyranone compound and a particular benzaldehyde compound are reacted.
The present invention is a new tetralone or benzopyranone derivative represented by a particular general formula (I) (see formula I) wherein R1 represents a hydroxy group, an alkyloxy group or an aralkyloxy group, R2-R6 represent hydrogen, a hydroxy group, a straight or branched alkyloxy or aralkyloxy group having 1-6 carbon atoms, a halogen, an amino group or an alkylene dioxy group joined at R2 and R3, R3 and R4, R4 and R5, R5 and R6, and A represents a methylene or oxygen, but provided that when R1 is methoxy, R2-R6 are all hydrogens and A is the methylene.
In the production, a particular tetralone or benzopyranone compound and a particular benzaldehyde compound are reacted.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9-28258 | 1997-01-29 | ||
| JP2825897 | 1997-01-29 | ||
| JP9225564A JPH10273467A (en) | 1997-01-29 | 1997-08-08 | New tetralone or benzopyranone derivative and its production |
| JP9-225564 | 1997-08-08 | ||
| PCT/JP1998/000344 WO1998032724A1 (en) | 1997-01-29 | 1998-01-28 | Novel tetralone or benzopyranone derivatives and process for producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2250258A1 true CA2250258A1 (en) | 1998-07-30 |
| CA2250258C CA2250258C (en) | 2006-02-21 |
Family
ID=35929974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002250258A Expired - Fee Related CA2250258C (en) | 1997-01-29 | 1998-01-28 | Novel tetralone or benzopyranone derivatives and process for producing the same |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2250258C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011156889A1 (en) * | 2010-06-14 | 2011-12-22 | Trt Pharma Inc. | Novel modulators of nrf2 and uses thereof |
-
1998
- 1998-01-28 CA CA002250258A patent/CA2250258C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011156889A1 (en) * | 2010-06-14 | 2011-12-22 | Trt Pharma Inc. | Novel modulators of nrf2 and uses thereof |
| US9139592B2 (en) | 2010-06-14 | 2015-09-22 | Trt Pharma Inc. | Modulators of Nrf2 and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2250258C (en) | 2006-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |