CA2248881A1 - Composition ophtalmologique subissant une transition de phase liquide/gel - Google Patents
Composition ophtalmologique subissant une transition de phase liquide/gel Download PDFInfo
- Publication number
- CA2248881A1 CA2248881A1 CA 2248881 CA2248881A CA2248881A1 CA 2248881 A1 CA2248881 A1 CA 2248881A1 CA 2248881 CA2248881 CA 2248881 CA 2248881 A CA2248881 A CA 2248881A CA 2248881 A1 CA2248881 A1 CA 2248881A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- pilocarpine
- polysaccharide
- component
- phase transition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention se rapporte à une composition ophtalmologique destinée à être mise en contact avec le fluide lacrimal, à être administrée sous une forme liquide non gélifiée et à se gélifier in situ. Cette composition renferme au moins un polysaccharide dans une solution aqueuse et subit une transition de phase liquide-gel se gélifiant in situ sous l'effet d'une augmentation de la force ionique du fluide lacrimal. L'invention concerne également une substance pharmaceutiquement active telle que la pilocarpine ou un sel pharmaceutiquement acceptable de celle-ci. La composition comprend un premier composant qui est une solution aqueuse acide de policarpine et d'un second composant qui est une solution aqueuse neutre ou alcaline d'un polysaccharide qui subit la transition de phase liquide/gel sous l'effet d'une augmentation de la force ionique, ces composants étant mélangés extemporanément au moment de leur première utilisation.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1334396P | 1996-03-13 | 1996-03-13 | |
| US60/013,343 | 1996-03-13 | ||
| FR9603142A FR2746014B1 (fr) | 1996-03-13 | 1996-03-13 | Composition ophtalmologique du type subissant une transition de phase liquide-gel |
| FR9603142 | 1996-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2248881A1 true CA2248881A1 (fr) | 1997-09-18 |
Family
ID=26232584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2248881 Abandoned CA2248881A1 (fr) | 1996-03-13 | 1997-03-12 | Composition ophtalmologique subissant une transition de phase liquide/gel |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0893990A1 (fr) |
| JP (1) | JP2000506182A (fr) |
| AU (1) | AU2287597A (fr) |
| CA (1) | CA2248881A1 (fr) |
| WO (1) | WO1997033562A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1229940T3 (da) * | 1999-11-15 | 2014-08-18 | Piramal Healthcare Canada Ltd | Temperaturstyret og ph-afhængig selvgelerende, vandig biopolymeropløsning |
| GR1004266B (el) * | 2001-04-30 | 2003-06-18 | Ηλιας Κ. Παπαδοπουλος | Φαρμακευτικο παρασκευασμα για την διαγνωση και θεραπεια της στυτικης δυσλειτουργιας |
| JP2010031052A (ja) * | 2002-04-08 | 2010-02-12 | Lion Corp | 眼科用組成物、及び眼科製剤用防腐組成物 |
| JP4725699B2 (ja) * | 2002-04-08 | 2011-07-13 | ライオン株式会社 | 眼科用組成物及び眼科用組成物配合用防腐剤 |
| WO2016100228A2 (fr) * | 2014-12-15 | 2016-06-23 | Nanosphere Health Sciences, Llc | Méthodes de traitement de troubles inflammatoires et d'inflammation globale au moyen de compositions comprenant des nanoparticules phospholipidiques encapsulant des ains |
| WO2018033792A2 (fr) | 2016-08-19 | 2018-02-22 | Orasis Pharmaceuticals Ltd. | Compositions pharmaceutiques ophtalmiques et utilisations associées |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0056420A1 (fr) * | 1981-01-15 | 1982-07-28 | Schering Corporation | Gel ophtalmique |
| SE9301877D0 (sv) * | 1993-06-02 | 1993-06-02 | Kabi Pharmacia Ab | In situ gel for therapeutic use |
-
1997
- 1997-03-12 JP JP9532296A patent/JP2000506182A/ja active Pending
- 1997-03-12 EP EP97915364A patent/EP0893990A1/fr not_active Withdrawn
- 1997-03-12 AU AU22875/97A patent/AU2287597A/en not_active Abandoned
- 1997-03-12 WO PCT/EP1997/001285 patent/WO1997033562A1/fr not_active Application Discontinuation
- 1997-03-12 CA CA 2248881 patent/CA2248881A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997033562A1 (fr) | 1997-09-18 |
| EP0893990A1 (fr) | 1999-02-03 |
| AU2287597A (en) | 1997-10-01 |
| JP2000506182A (ja) | 2000-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |