CA2241186A1 - Benzimidazole derivatives - Google Patents

Benzimidazole derivatives

Info

Publication number
CA2241186A1
CA2241186A1 CA002241186A CA2241186A CA2241186A1 CA 2241186 A1 CA2241186 A1 CA 2241186A1 CA 002241186 A CA002241186 A CA 002241186A CA 2241186 A CA2241186 A CA 2241186A CA 2241186 A1 CA2241186 A1 CA 2241186A1
Authority
CA
Canada
Prior art keywords
group
hypertension
carboxyl group
disorders
atherosclerosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002241186A
Other languages
French (fr)
Other versions
CA2241186C (en
Inventor
Noritsugu Yamasaki
Takafumi Imoto
Yoshiyuki Murai
Takahiro Hiramura
Teruo Oku
Kouzou Sawada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co., Ltd.
Noritsugu Yamasaki
Takafumi Imoto
Yoshiyuki Murai
Takahiro Hiramura
Teruo Oku
Kouzou Sawada
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co., Ltd., Noritsugu Yamasaki, Takafumi Imoto, Yoshiyuki Murai, Takahiro Hiramura, Teruo Oku, Kouzou Sawada, Astellas Pharma Inc. filed Critical Fujisawa Pharmaceutical Co., Ltd.
Priority claimed from PCT/JP1996/003858 external-priority patent/WO1997024334A1/en
Publication of CA2241186A1 publication Critical patent/CA2241186A1/en
Application granted granted Critical
Publication of CA2241186C publication Critical patent/CA2241186C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel benzimidazole derivatives represented by the formula (I):
(see formula I) wherein R, is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl group, or their pharmaceutically acceptable salts.
Because of their blood sugar-depressing effect or PDE5 inhibitory effect, these compounds or salts thereof are useful as medicines for treating impaired glucose tolerance, diabetes, diabetic complications, syndrome of insulin resistance, hyperlipidemia, atherosclerosis, cardiovascular disorders, hyperglycemia, or hypertension; or stenocardia, hypertension, pulmonary hypertension, congestive heart failure, glomerulopathy, tubulointerstitial disorders, renal failure, atherosclerosis, angiostenosis, distal angiopathy, cerebral apoplexy, chronic reversible obstructions, allergic rhinitis, urticaria, glaucoma, diseases characterized by enteromotility disorders, impotence, diabetic complications, nephritis, cancerous cachexia, or restenosis after PTCA.
CA002241186A 1995-12-28 1996-12-27 Benzimidazole derivatives Expired - Fee Related CA2241186C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP34342595 1995-12-28
JP8/287676 1996-10-08
JP7/343425 1996-10-08
JP28767696 1996-10-08
PCT/JP1996/003858 WO1997024334A1 (en) 1995-12-28 1996-12-27 Benzimidazole derivatives

Publications (2)

Publication Number Publication Date
CA2241186A1 true CA2241186A1 (en) 1997-06-28
CA2241186C CA2241186C (en) 2006-02-14

Family

ID=35892342

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002241186A Expired - Fee Related CA2241186C (en) 1995-12-28 1996-12-27 Benzimidazole derivatives

Country Status (1)

Country Link
CA (1) CA2241186C (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US7576079B2 (en) 2001-07-25 2009-08-18 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US7582770B2 (en) 2004-02-20 2009-09-01 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7838537B2 (en) 2003-01-22 2010-11-23 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7888363B2 (en) 2003-01-22 2011-02-15 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US8076365B2 (en) 2005-08-12 2011-12-13 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US6479508B1 (en) 2000-07-06 2002-11-12 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US6794404B2 (en) 2000-07-06 2004-09-21 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US7439258B2 (en) 2000-07-06 2008-10-21 Boehringer Ingelheim (Canada) Ltd Viral polymerase inhibitors
US7803944B2 (en) 2001-07-25 2010-09-28 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7576079B2 (en) 2001-07-25 2009-08-18 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US7893084B2 (en) 2001-07-25 2011-02-22 Boehringer Ingelheim Canada Ltd. Viral polymerase inhibitors
US7838537B2 (en) 2003-01-22 2010-11-23 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7888363B2 (en) 2003-01-22 2011-02-15 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7582770B2 (en) 2004-02-20 2009-09-01 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7879851B2 (en) 2004-02-20 2011-02-01 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US8030309B2 (en) 2004-02-20 2011-10-04 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US8076365B2 (en) 2005-08-12 2011-12-13 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors

Also Published As

Publication number Publication date
CA2241186C (en) 2006-02-14

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MKLA Lapsed

Effective date: 20151229