CA2241186A1 - Benzimidazole derivatives - Google Patents
Benzimidazole derivativesInfo
- Publication number
- CA2241186A1 CA2241186A1 CA002241186A CA2241186A CA2241186A1 CA 2241186 A1 CA2241186 A1 CA 2241186A1 CA 002241186 A CA002241186 A CA 002241186A CA 2241186 A CA2241186 A CA 2241186A CA 2241186 A1 CA2241186 A1 CA 2241186A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- hypertension
- carboxyl group
- disorders
- atherosclerosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel benzimidazole derivatives represented by the formula (I):
(see formula I) wherein R, is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl group, or their pharmaceutically acceptable salts.
Because of their blood sugar-depressing effect or PDE5 inhibitory effect, these compounds or salts thereof are useful as medicines for treating impaired glucose tolerance, diabetes, diabetic complications, syndrome of insulin resistance, hyperlipidemia, atherosclerosis, cardiovascular disorders, hyperglycemia, or hypertension; or stenocardia, hypertension, pulmonary hypertension, congestive heart failure, glomerulopathy, tubulointerstitial disorders, renal failure, atherosclerosis, angiostenosis, distal angiopathy, cerebral apoplexy, chronic reversible obstructions, allergic rhinitis, urticaria, glaucoma, diseases characterized by enteromotility disorders, impotence, diabetic complications, nephritis, cancerous cachexia, or restenosis after PTCA.
(see formula I) wherein R, is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl group, or their pharmaceutically acceptable salts.
Because of their blood sugar-depressing effect or PDE5 inhibitory effect, these compounds or salts thereof are useful as medicines for treating impaired glucose tolerance, diabetes, diabetic complications, syndrome of insulin resistance, hyperlipidemia, atherosclerosis, cardiovascular disorders, hyperglycemia, or hypertension; or stenocardia, hypertension, pulmonary hypertension, congestive heart failure, glomerulopathy, tubulointerstitial disorders, renal failure, atherosclerosis, angiostenosis, distal angiopathy, cerebral apoplexy, chronic reversible obstructions, allergic rhinitis, urticaria, glaucoma, diseases characterized by enteromotility disorders, impotence, diabetic complications, nephritis, cancerous cachexia, or restenosis after PTCA.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP34342595 | 1995-12-28 | ||
JP8/287676 | 1996-10-08 | ||
JP7/343425 | 1996-10-08 | ||
JP28767696 | 1996-10-08 | ||
PCT/JP1996/003858 WO1997024334A1 (en) | 1995-12-28 | 1996-12-27 | Benzimidazole derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2241186A1 true CA2241186A1 (en) | 1997-06-28 |
CA2241186C CA2241186C (en) | 2006-02-14 |
Family
ID=35892342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002241186A Expired - Fee Related CA2241186C (en) | 1995-12-28 | 1996-12-27 | Benzimidazole derivatives |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2241186C (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
US7576079B2 (en) | 2001-07-25 | 2009-08-18 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
US7582770B2 (en) | 2004-02-20 | 2009-09-01 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7838537B2 (en) | 2003-01-22 | 2010-11-23 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7888363B2 (en) | 2003-01-22 | 2011-02-15 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US8076365B2 (en) | 2005-08-12 | 2011-12-13 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
-
1996
- 1996-12-27 CA CA002241186A patent/CA2241186C/en not_active Expired - Fee Related
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
US6479508B1 (en) | 2000-07-06 | 2002-11-12 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
US6794404B2 (en) | 2000-07-06 | 2004-09-21 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
US7439258B2 (en) | 2000-07-06 | 2008-10-21 | Boehringer Ingelheim (Canada) Ltd | Viral polymerase inhibitors |
US7803944B2 (en) | 2001-07-25 | 2010-09-28 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7576079B2 (en) | 2001-07-25 | 2009-08-18 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
US7893084B2 (en) | 2001-07-25 | 2011-02-22 | Boehringer Ingelheim Canada Ltd. | Viral polymerase inhibitors |
US7838537B2 (en) | 2003-01-22 | 2010-11-23 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7888363B2 (en) | 2003-01-22 | 2011-02-15 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7582770B2 (en) | 2004-02-20 | 2009-09-01 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7879851B2 (en) | 2004-02-20 | 2011-02-01 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US8030309B2 (en) | 2004-02-20 | 2011-10-04 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US8076365B2 (en) | 2005-08-12 | 2011-12-13 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
Also Published As
Publication number | Publication date |
---|---|
CA2241186C (en) | 2006-02-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20151229 |