CA2239969A1 - Reactifs permettant de mesurer des teneurs en plomb au moyen de la quantification du porphobilinogene - Google Patents
Reactifs permettant de mesurer des teneurs en plomb au moyen de la quantification du porphobilinogene Download PDFInfo
- Publication number
- CA2239969A1 CA2239969A1 CA 2239969 CA2239969A CA2239969A1 CA 2239969 A1 CA2239969 A1 CA 2239969A1 CA 2239969 CA2239969 CA 2239969 CA 2239969 A CA2239969 A CA 2239969A CA 2239969 A1 CA2239969 A1 CA 2239969A1
- Authority
- CA
- Canada
- Prior art keywords
- porphobilinogen
- carrier material
- linking group
- immunogenic carrier
- linked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Des immuno-essais et des réactifs permettant de mesurer la teneur en plomb dans un échantillon d'essai au moyen de la quantification du porphobilinogène utilisent des anticorps préparés avec des composés représentés par les formules (I) et (II) dans lesquelles X et Y sont des groupes de liaison constitués de 0 à 2 hétéroatomes et de 0 à 8 atomes de carbone liés à un porteur immunogénique P qui est de préférence de l'albumine de sérum bovin. L'invention concerne également la synthèse de traceurs de fluorescéine dont la structure est représentée par les formules (V) et (VII) dans lesquelles A et C sont des groupes de liaison constitués de 0 à 2 hétéroatomes et de 0 à 8 atomes de carbone liés à une fraction détectable Q qui est de préférence de la fluorescéine ou un dérivé de fluorescéine.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58115195A | 1995-12-29 | 1995-12-29 | |
US08/581,151 | 1995-12-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2239969A1 true CA2239969A1 (fr) | 1997-07-10 |
Family
ID=24324093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2239969 Abandoned CA2239969A1 (fr) | 1995-12-29 | 1996-12-16 | Reactifs permettant de mesurer des teneurs en plomb au moyen de la quantification du porphobilinogene |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0876616A2 (fr) |
JP (1) | JP2000506603A (fr) |
CA (1) | CA2239969A1 (fr) |
WO (1) | WO1997024621A2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1357110A1 (fr) * | 2002-04-24 | 2003-10-29 | Reinhard Neier | Procédé de préparation de phorphobilinogène, le composé en tant que sel stabilisé et ses produits intermédiaires |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993001310A1 (fr) * | 1991-07-11 | 1993-01-21 | University Of Maryland At Baltimore | Analyse de plomb |
US5518886A (en) * | 1993-08-03 | 1996-05-21 | Fox Chase Cancer Center | Blood lead diagnostic assay |
US5597702A (en) * | 1993-12-21 | 1997-01-28 | Abbott Laboratories | Automated lead assay |
-
1996
- 1996-12-16 WO PCT/US1996/019544 patent/WO1997024621A2/fr not_active Application Discontinuation
- 1996-12-16 CA CA 2239969 patent/CA2239969A1/fr not_active Abandoned
- 1996-12-16 JP JP9524338A patent/JP2000506603A/ja active Pending
- 1996-12-16 EP EP96943648A patent/EP0876616A2/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP0876616A2 (fr) | 1998-11-11 |
WO1997024621A2 (fr) | 1997-07-10 |
JP2000506603A (ja) | 2000-05-30 |
WO1997024621A3 (fr) | 1997-08-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |