CA2239969A1 - Reactifs permettant de mesurer des teneurs en plomb au moyen de la quantification du porphobilinogene - Google Patents

Reactifs permettant de mesurer des teneurs en plomb au moyen de la quantification du porphobilinogene Download PDF

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Publication number
CA2239969A1
CA2239969A1 CA 2239969 CA2239969A CA2239969A1 CA 2239969 A1 CA2239969 A1 CA 2239969A1 CA 2239969 CA2239969 CA 2239969 CA 2239969 A CA2239969 A CA 2239969A CA 2239969 A1 CA2239969 A1 CA 2239969A1
Authority
CA
Canada
Prior art keywords
porphobilinogen
carrier material
linking group
immunogenic carrier
linked
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2239969
Other languages
English (en)
Inventor
Maciej Adamczyk
Jeffrey R. Fishpaugh
Kevin Heuser
John M. Ramp.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2239969A1 publication Critical patent/CA2239969A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Des immuno-essais et des réactifs permettant de mesurer la teneur en plomb dans un échantillon d'essai au moyen de la quantification du porphobilinogène utilisent des anticorps préparés avec des composés représentés par les formules (I) et (II) dans lesquelles X et Y sont des groupes de liaison constitués de 0 à 2 hétéroatomes et de 0 à 8 atomes de carbone liés à un porteur immunogénique P qui est de préférence de l'albumine de sérum bovin. L'invention concerne également la synthèse de traceurs de fluorescéine dont la structure est représentée par les formules (V) et (VII) dans lesquelles A et C sont des groupes de liaison constitués de 0 à 2 hétéroatomes et de 0 à 8 atomes de carbone liés à une fraction détectable Q qui est de préférence de la fluorescéine ou un dérivé de fluorescéine.
CA 2239969 1995-12-29 1996-12-16 Reactifs permettant de mesurer des teneurs en plomb au moyen de la quantification du porphobilinogene Abandoned CA2239969A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58115195A 1995-12-29 1995-12-29
US08/581,151 1995-12-29

Publications (1)

Publication Number Publication Date
CA2239969A1 true CA2239969A1 (fr) 1997-07-10

Family

ID=24324093

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2239969 Abandoned CA2239969A1 (fr) 1995-12-29 1996-12-16 Reactifs permettant de mesurer des teneurs en plomb au moyen de la quantification du porphobilinogene

Country Status (4)

Country Link
EP (1) EP0876616A2 (fr)
JP (1) JP2000506603A (fr)
CA (1) CA2239969A1 (fr)
WO (1) WO1997024621A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1357110A1 (fr) * 2002-04-24 2003-10-29 Reinhard Neier Procédé de préparation de phorphobilinogène, le composé en tant que sel stabilisé et ses produits intermédiaires

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993001310A1 (fr) * 1991-07-11 1993-01-21 University Of Maryland At Baltimore Analyse de plomb
US5518886A (en) * 1993-08-03 1996-05-21 Fox Chase Cancer Center Blood lead diagnostic assay
US5597702A (en) * 1993-12-21 1997-01-28 Abbott Laboratories Automated lead assay

Also Published As

Publication number Publication date
EP0876616A2 (fr) 1998-11-11
WO1997024621A2 (fr) 1997-07-10
JP2000506603A (ja) 2000-05-30
WO1997024621A3 (fr) 1997-08-14

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