CA2237774A1 - Dihydropirimidines et leurs emplois - Google Patents

Dihydropirimidines et leurs emplois Download PDF

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Publication number
CA2237774A1
CA2237774A1 CA002237774A CA2237774A CA2237774A1 CA 2237774 A1 CA2237774 A1 CA 2237774A1 CA 002237774 A CA002237774 A CA 002237774A CA 2237774 A CA2237774 A CA 2237774A CA 2237774 A1 CA2237774 A1 CA 2237774A1
Authority
CA
Canada
Prior art keywords
compound
branched
straight chained
subject
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002237774A
Other languages
English (en)
Inventor
Michael A. Patane
Shou Wu Miao
Wai C. Wong
Dhanapalan Nagarathnam
Charles Gluchowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Synaptic Pharmaceutical Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1995/015025 external-priority patent/WO1996014846A1/fr
Application filed by Individual filed Critical Individual
Publication of CA2237774A1 publication Critical patent/CA2237774A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

Cette invention concerne des composés de dihydropirimidines constituants des antagonistes sélectifs des récepteurs .alpha.¿1A? humains. Cette invention concerne également des utilisations de ces composés pour abaisser la pression intra-occulaire, inhiber la synthèse du cholestérol, décontracter les tissus des voies urinaires inférieures, le traitement de l'adénome prostatique, de l'impuissance, de l'arythmie cardiaque et dans le traitement de toutes maladies dans lesquelles l'antagonisme du récepteur .alpha.¿1A? peut être utile. L'invention concerne en outre une composition pharmaceutique comprenant une dose thérapeutique efficace des composés ci-dessus définis ainsi qu'un excipient pharmaceutiquement acceptable.
CA002237774A 1995-11-16 1996-11-15 Dihydropirimidines et leurs emplois Abandoned CA2237774A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
WOPCT/US95/15025 1995-11-16
PCT/US1995/015025 WO1996014846A1 (fr) 1994-11-16 1995-11-16 Dihydropyrimidines et leurs utilisations
US64877096A 1996-05-16 1996-05-16
US08/648,770 1996-05-16

Publications (1)

Publication Number Publication Date
CA2237774A1 true CA2237774A1 (fr) 1997-05-22

Family

ID=24602162

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002237774A Abandoned CA2237774A1 (fr) 1995-11-16 1996-11-15 Dihydropirimidines et leurs emplois

Country Status (4)

Country Link
EP (1) EP0866708A4 (fr)
JP (1) JP2000500470A (fr)
AU (1) AU714287B2 (fr)
CA (1) CA2237774A1 (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5659778A (en) * 1979-10-23 1981-05-23 Showa Denko Kk Dimethylthienopyrimidione derivative
HUT42077A (en) * 1985-06-03 1987-06-29 Squibb & Sons Inc Process for producing diesters of 2-tioxo- or 2-oxo-pyrimidine-1,5-dicarboxylic acid and 1-acyl-pyrimidine-5-carboxylic acids and esters
IL81800A0 (en) * 1986-03-14 1987-10-20 Squibb & Sons Inc 1,2,3,4-tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-((substituted amino)carbonyl)-2-thioxo(or oxo)-5-pyrimidine-carboxylic acids and esters and pharmaceutical compositions containing the same
US4703120A (en) * 1986-04-28 1987-10-27 Ortho Pharmaceutical Corporation Furo(3,4-d)pyrimidine-2,4-dione derivatives and intermediates thereof

Also Published As

Publication number Publication date
JP2000500470A (ja) 2000-01-18
EP0866708A1 (fr) 1998-09-30
AU1055897A (en) 1997-06-05
EP0866708A4 (fr) 1999-05-06
AU714287B2 (en) 1999-12-23

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Legal Events

Date Code Title Description
FZDE Dead