CA2233882A1 - L'exotoxine de pseudomonas: un vecteur immunogene pour vaccins de synthese conjugues - Google Patents

L'exotoxine de pseudomonas: un vecteur immunogene pour vaccins de synthese conjugues Download PDF

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Publication number
CA2233882A1
CA2233882A1 CA002233882A CA2233882A CA2233882A1 CA 2233882 A1 CA2233882 A1 CA 2233882A1 CA 002233882 A CA002233882 A CA 002233882A CA 2233882 A CA2233882 A CA 2233882A CA 2233882 A1 CA2233882 A1 CA 2233882A1
Authority
CA
Canada
Prior art keywords
gnrh
gly
leu
peptide
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002233882A
Other languages
English (en)
Inventor
Gerard J. Hickey
Kenneth L. Mohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602878.2A external-priority patent/GB9602878D0/en
Application filed by Individual filed Critical Individual
Publication of CA2233882A1 publication Critical patent/CA2233882A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'exotoxine de Pseudomonas et certaines de ses variantes sont des protéines vecteurs immunogènes puissantes de la GnRH. Les vaccins contenant une GnRH en association avec l'exotoxine de Pseudomonas permettent d'obtenir chez des animaux des titres élevés d'anticorps anti-GnRH. Il en résulte que de tels vaccins conviennent particulièrement au contrôle de la fertilité, à l'atténuation des comportements indésirables dépendants des hormones de reproduction, et au traitement des tumeurs réagissant aux stéroïdes sexuels.
CA002233882A 1995-10-27 1996-10-23 L'exotoxine de pseudomonas: un vecteur immunogene pour vaccins de synthese conjugues Abandoned CA2233882A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US801895P 1995-10-27 1995-10-27
US60/008,018 1995-10-27
GB9602878.2 1996-02-13
GBGB9602878.2A GB9602878D0 (en) 1996-02-13 1996-02-13 Pseudomonas exotoxin as immunogenic carrier in synthetic conjugate vaccines

Publications (1)

Publication Number Publication Date
CA2233882A1 true CA2233882A1 (fr) 1997-05-01

Family

ID=26308672

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002233882A Abandoned CA2233882A1 (fr) 1995-10-27 1996-10-23 L'exotoxine de pseudomonas: un vecteur immunogene pour vaccins de synthese conjugues

Country Status (5)

Country Link
EP (1) EP0871481A1 (fr)
JP (1) JPH11515013A (fr)
AU (1) AU7718696A (fr)
CA (1) CA2233882A1 (fr)
WO (1) WO1997015325A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688506A (en) * 1994-01-27 1997-11-18 Aphton Corp. Immunogens against gonadotropin releasing hormone
US6838553B1 (en) * 1999-10-05 2005-01-04 Academia Sinica Peptide repeat immunogens
US6783761B2 (en) 2000-05-05 2004-08-31 Aphton Corporation Chimeric peptide immunogens
CN1683416A (zh) * 2004-04-13 2005-10-19 李相哲 高效低毒的系列功能蛋白
ES2702650T3 (es) 2005-07-29 2019-03-04 The Government Of The Us Secretary Of Health And Human Services Exotoxinas de pseudomonas mutadas con antigenicidad reducida
AU2012216642B2 (en) * 2005-07-29 2014-06-12 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH Mutated pseudomonas exotoxins with reduced antigenicity
CN101343328B (zh) * 2008-08-25 2011-06-01 北京博翱泰生物技术有限公司 靶特异性双突变体融合蛋白质
US20220211860A1 (en) * 2019-05-02 2022-07-07 The University Of Sydney Peptide derivatives and conjugates thereof for treating cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009799A1 (fr) * 1989-02-23 1990-09-07 Colorado State University Research Foundation ANALOGUES DE GnRH DETRUISANT LES GONADOTROPES

Also Published As

Publication number Publication date
EP0871481A1 (fr) 1998-10-21
WO1997015325A1 (fr) 1997-05-01
AU7718696A (en) 1997-05-15
JPH11515013A (ja) 1999-12-21

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Legal Events

Date Code Title Description
FZDE Discontinued