CA2233560A1 - Sulfonamide inhibitors of matrix metalloproteinases - Google Patents
Sulfonamide inhibitors of matrix metalloproteinasesInfo
- Publication number
- CA2233560A1 CA2233560A1 CA002233560A CA2233560A CA2233560A1 CA 2233560 A1 CA2233560 A1 CA 2233560A1 CA 002233560 A CA002233560 A CA 002233560A CA 2233560 A CA2233560 A CA 2233560A CA 2233560 A1 CA2233560 A1 CA 2233560A1
- Authority
- CA
- Canada
- Prior art keywords
- matrix metalloproteinases
- gelatinase
- inhibitors
- compounds
- ulcers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000002274 Matrix Metalloproteinases Human genes 0.000 title abstract 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- 150000003456 sulfonamides Chemical class 0.000 title 1
- 208000025865 Ulcer Diseases 0.000 abstract 2
- 231100000397 ulcer Toxicity 0.000 abstract 2
- 208000037260 Atherosclerotic Plaque Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 102000013382 Gelatinases Human genes 0.000 abstract 1
- 108010026132 Gelatinases Proteins 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 102000000424 Matrix Metalloproteinase 2 Human genes 0.000 abstract 1
- 108010016165 Matrix Metalloproteinase 2 Proteins 0.000 abstract 1
- 102000000422 Matrix Metalloproteinase 3 Human genes 0.000 abstract 1
- 108010016160 Matrix Metalloproteinase 3 Proteins 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- -1 Sulfonamide compounds Chemical class 0.000 abstract 1
- 206010064996 Ulcerative keratitis Diseases 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000009545 invasion Effects 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 230000005747 tumor angiogenesis Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Sulfonamide compounds of the following general formula:
(see formula I) are described which are inhibitors of matrix metalloproteinases, particularly stromelysin-1 and gelatinase A (72 kD gelatinase). Also described are methods for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes using the compounds.
(see formula I) are described which are inhibitors of matrix metalloproteinases, particularly stromelysin-1 and gelatinase A (72 kD gelatinase). Also described are methods for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes using the compounds.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US737295P | 1995-11-17 | 1995-11-17 | |
| US60/007,372 | 1995-11-17 | ||
| PCT/US1996/016761 WO1997019068A1 (en) | 1995-11-17 | 1996-10-18 | Sulfonamide inhibitors of matrix metalloproteinases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2233560A1 true CA2233560A1 (en) | 1997-05-29 |
| CA2233560C CA2233560C (en) | 2005-12-20 |
Family
ID=35645828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002233560A Expired - Fee Related CA2233560C (en) | 1995-11-17 | 1996-10-18 | Sulfonamide inhibitors of matrix metalloproteinases |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2233560C (en) |
-
1996
- 1996-10-18 CA CA002233560A patent/CA2233560C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2233560C (en) | 2005-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |