CA2229479A1 - Method of promoting angiogenesis - Google Patents

Method of promoting angiogenesis

Info

Publication number
CA2229479A1
CA2229479A1 CA002229479A CA2229479A CA2229479A1 CA 2229479 A1 CA2229479 A1 CA 2229479A1 CA 002229479 A CA002229479 A CA 002229479A CA 2229479 A CA2229479 A CA 2229479A CA 2229479 A1 CA2229479 A1 CA 2229479A1
Authority
CA
Canada
Prior art keywords
relaxin
treatment
administration
recombinant human
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002229479A
Other languages
French (fr)
Other versions
CA2229479C (en
Inventor
Elaine Unemori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corthera Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2229479A1 publication Critical patent/CA2229479A1/en
Application granted granted Critical
Publication of CA2229479C publication Critical patent/CA2229479C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Relaxin is useful for promoting angiogenesis and the treatment of infections or ischemic wounds where the injury results from lack of oxygen due to poor circulation.

Claims (22)

1. A method for treating an infection or ischemic wound in a mammal in need thereof comprising administering a therapeutically effective amount of relaxin.
2. The method of treatment of Claim 1 comprising the administration of relaxin in an amount sufficient to maintain a serum concentration of at least about 1 ng/ml.
3. The method of treatment of Claim 1 comprising the administration of recombinant human relaxin (H2).
4. The method of treatment of Claim 2 comprising the administration of recombinant human relaxin (H2).
5. The method of treatment of Claim 3 wherein said relaxin is administered parenterally.
6. The method of treatment of Claim 5 wherein said relaxin is administered by subcutaneous injection.
7. The method of treatment of Claim 3 wherein said relaxin is administered by inhalation to the patient's respiratory tract.
8. The method of treatment of Claim 3 wherein said infection or ischemic wound is one where the injury is the result from lack of oxygen due to poor circulation.
9. The method of treatment of Claim 8 wherein said lack of oxygen due to poor circulation is the result of a disease.
10. The method of treatment of Claim 9 wherein the disease is scleroderma or diabetes.
11. The method of treatment of Claim 1 wherein the wound is an ischemic ulcer.
12. A method for promoting angiogenesis in a mammal in need thereof comprising administering a therapeutically effective amount of relaxin.
13. The method of Claim 12 comprising the administration of relaxin in an amount sufficient to maintain a serum concentration of at least about 1 ng/ml.
14. The method of Claim 12 comprising the administration of recombinant human relaxin (H2).
15. The method of Claim 13 comprising the administration of recombinant human relaxin (H2).
16. The method of Claim 14 wherein said relaxin is administered parenterally.
17. The method of Claim 16 wherein said relaxin is administered by subcutaneous injection.
18. The method of Claim 14 wherein said relaxin is administered by inhalation to the patient's respiratory tract.
19. A method of using relaxin for the manufacture of a medicant for the treatment of an infection or ischemic wound.
20. The method of Claim 19 wherein the relaxin is recombinant human relaxin (H2).
21. A method of using relaxin for the manufacture of a medicant for the promotion of angiogenesis.
22. The method of Claim 21 wherein the relaxin is recombinant human relaxin (H2).
CA2229479A 1995-08-15 1996-08-15 Method of promoting angiogenesis Expired - Lifetime CA2229479C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US235595P 1995-08-15 1995-08-15
US60/002,355 1995-08-15
PCT/US1996/013321 WO1997006814A1 (en) 1995-08-15 1996-08-15 Method of promoting angiogenesis

Publications (2)

Publication Number Publication Date
CA2229479A1 true CA2229479A1 (en) 1997-02-27
CA2229479C CA2229479C (en) 2010-03-30

Family

ID=21700396

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2229479A Expired - Lifetime CA2229479C (en) 1995-08-15 1996-08-15 Method of promoting angiogenesis

Country Status (9)

Country Link
US (3) US6211147B1 (en)
EP (1) EP0845992B1 (en)
JP (1) JP4568383B2 (en)
AT (1) ATE228004T1 (en)
AU (1) AU6777196A (en)
CA (1) CA2229479C (en)
DE (1) DE69624925T2 (en)
ES (1) ES2187667T3 (en)
WO (1) WO1997006814A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2397200C (en) * 2000-02-09 2010-11-23 Connetics Corporation Use of relaxin to treat diseases related to vasoconstriction
ITRM20020119A1 (en) * 2002-03-05 2003-09-05 Geymonat Spa COMPOSITIONS CONTAINING PLGF FOR PHARMACEUTICAL AND COSMETIC USE.
US7878978B2 (en) * 2004-03-18 2011-02-01 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
CA2559745C (en) * 2004-03-19 2010-11-02 Bas Medical, Inc. Use of relaxin to increase arterial compliance
CA2563433C (en) * 2004-04-30 2010-07-13 Bas Medical, Inc. Methods and compositions for control of fetal growth via modulation of relaxin
US7893244B2 (en) * 2005-04-12 2011-02-22 Intradigm Corporation Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases
CA2604441A1 (en) * 2005-04-12 2006-10-19 Intradigm Corporation Composition and methods of rnai therapeutics for treatment of cancer and other neovascularization diseases
US20060281669A1 (en) * 2005-06-13 2006-12-14 Yue Samuel K Method and compositions for the treatment of diabetes and related complications
WO2007027168A1 (en) * 2005-08-29 2007-03-08 Carrier Corporation Compressor muffler
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
CA2724542A1 (en) * 2008-05-16 2009-11-19 Corthera, Inc. Method of administering relaxin to reduce cervical dilation
MX2010012450A (en) 2008-05-16 2011-03-21 Corthera Inc Star Treating dyspnea associated with acute heart failure with relaxin.
EP2278993A4 (en) * 2008-05-16 2012-09-12 Corthera Inc Method of promoting wound healing
BRPI0805852A8 (en) * 2008-09-05 2021-06-29 Univ Rio De Janeiro protein acid polymers, production processes, use of protein acid polymers, pharmaceutical composition and treatment method
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
CA2737461A1 (en) 2008-09-19 2010-03-25 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
AU2010278894B2 (en) 2009-07-30 2014-01-30 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
MY162837A (en) 2010-08-17 2017-07-31 Ambrx Inc Modified relaxin polypeptides and their uses
US10493131B2 (en) * 2011-08-31 2019-12-03 University Of Florida Research Foundation, Incorporated Materials and methods for modulating activity of bone marrow derived cells
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US9526762B1 (en) * 2013-08-09 2016-12-27 William Marsh Rice University Multidomain peptides for promoting angiogenesis
EP4011919A3 (en) 2015-12-09 2022-10-12 The Scripps Research Institute Relaxin immunoglobulin fusion proteins and methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023321A (en) * 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
US5023088A (en) * 1987-06-25 1991-06-11 Alza Corporation Multi-unit delivery system
WO1989007945A1 (en) 1988-02-26 1989-09-08 Genentech, Inc. Human relaxin formulation
GB8907799D0 (en) * 1989-04-06 1989-05-17 Erba Carlo Spa Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases
CA2051375C (en) 1989-05-04 2000-09-12 Dennis J. Henner Process and compositions for the isolation of human relaxin
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5478807A (en) 1991-08-19 1995-12-26 Genentech, Inc. Use of relaxin in the treatment of bradycardia
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
US5952296A (en) 1993-07-27 1999-09-14 Bigazzi; Mario Method of using relaxin as therapeutic or preventing agent
US5811395A (en) * 1995-06-07 1998-09-22 Medical University Of South Carolina Relaxin analogs and derivatives methods and uses thereof
US5911997A (en) * 1995-06-07 1999-06-15 Connetics Corporation Relaxin-like factor and methods and uses thereof
US5753623A (en) * 1995-06-07 1998-05-19 Connetics Corporation Method of treatment for depression

Also Published As

Publication number Publication date
EP0845992A1 (en) 1998-06-10
JP4568383B2 (en) 2010-10-27
CA2229479C (en) 2010-03-30
ATE228004T1 (en) 2002-12-15
ES2187667T3 (en) 2003-06-16
US20010018418A1 (en) 2001-08-30
US20040192606A1 (en) 2004-09-30
US6780836B2 (en) 2004-08-24
DE69624925T2 (en) 2003-09-04
DE69624925D1 (en) 2003-01-02
EP0845992B1 (en) 2002-11-20
AU6777196A (en) 1997-03-12
US6211147B1 (en) 2001-04-03
WO1997006814A1 (en) 1997-02-27
JPH11511174A (en) 1999-09-28
EP0845992A4 (en) 2000-04-19

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Legal Events

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EEER Examination request
MKEX Expiry

Effective date: 20160815

MKEX Expiry

Effective date: 20160815