CA2221616A1 - Hibef51, recepteur de proteines g humaines - Google Patents

Hibef51, recepteur de proteines g humaines Download PDF

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Publication number
CA2221616A1
CA2221616A1 CA002221616A CA2221616A CA2221616A1 CA 2221616 A1 CA2221616 A1 CA 2221616A1 CA 002221616 A CA002221616 A CA 002221616A CA 2221616 A CA2221616 A CA 2221616A CA 2221616 A1 CA2221616 A1 CA 2221616A1
Authority
CA
Canada
Prior art keywords
polypeptide
receptor
compound
polynucleotide
polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002221616A
Other languages
English (en)
Inventor
Mark D. Adams
Yi Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to PCT/US1995/007225 priority Critical patent/WO1996039441A1/fr
Priority to AU26997/95A priority patent/AU2699795A/en
Priority to EP95922244A priority patent/EP0871668A4/fr
Priority to CA002221616A priority patent/CA2221616A1/fr
Publication of CA2221616A1 publication Critical patent/CA2221616A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne des polypeptides récepteurs couplés à des protéines G humaines et l'ADN (ARN) codant de tels polypeptides, ainsi qu'une procédure de production de ces polypeptides par techniques de recombinaison. Elle concerne également des procédés d'utilisation desdits polypeptides pour l'identification d'antagonistes et d'agonistes à ces polypeptides ainsi que des procédés d'application thérapeutique des agonistes et des antagonistes dans le traitement, respectivement, de la sous-expression et de la surexpression des polypeptides récepteurs. L'invention a en outre pour objet des méthodes de diagnostic permettant de détecter une mutation dans les séquences d'acides nucléiques des récepteurs, de même qu'un niveau de la forme soluble des récepteurs dans un échantillon tiré d'un hôte.
CA002221616A 1995-06-06 1995-06-06 Hibef51, recepteur de proteines g humaines Abandoned CA2221616A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PCT/US1995/007225 WO1996039441A1 (fr) 1995-06-06 1995-06-06 Hibef51, recepteur de proteines g humaines
AU26997/95A AU2699795A (en) 1995-06-06 1995-06-06 Human g-protein receptor hibef51
EP95922244A EP0871668A4 (fr) 1995-06-06 1995-06-06 Hibef51, recepteur de proteines g humaines
CA002221616A CA2221616A1 (fr) 1995-06-06 1995-06-06 Hibef51, recepteur de proteines g humaines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1995/007225 WO1996039441A1 (fr) 1995-06-06 1995-06-06 Hibef51, recepteur de proteines g humaines
CA002221616A CA2221616A1 (fr) 1995-06-06 1995-06-06 Hibef51, recepteur de proteines g humaines

Publications (1)

Publication Number Publication Date
CA2221616A1 true CA2221616A1 (fr) 1996-12-12

Family

ID=25679843

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002221616A Abandoned CA2221616A1 (fr) 1995-06-06 1995-06-06 Hibef51, recepteur de proteines g humaines

Country Status (4)

Country Link
EP (1) EP0871668A4 (fr)
AU (1) AU2699795A (fr)
CA (1) CA2221616A1 (fr)
WO (1) WO1996039441A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221627B1 (en) 1997-02-24 2001-04-24 Smithkline Beecham Corporation cDNA clone HDPB130 that encodes a novel human 7-transmembrane receptor
GB9725462D0 (en) * 1997-12-01 1998-01-28 Smithkline Beecham Plc Novel method

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262529A (en) * 1990-01-24 1993-11-16 President And Fellows Of Harvard College Diagnosis of hereditary retinal degenerative diseases
US5462856A (en) * 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins
JPH06511386A (ja) * 1991-10-01 1994-12-22 アメリカ合衆国 リガンドおよびリガンドのアンタゴニストを同定する方法
US5508384A (en) * 1992-09-10 1996-04-16 New York University Polypeptide derived from a popamine receptor, and compositions and methods thereof
IT1255697B (it) * 1992-09-29 1995-11-10 Enichem Spa Metodo per l'espressione nel lievito schizosaccharomyces pombe di recettori del sistema nervoso umano

Also Published As

Publication number Publication date
AU2699795A (en) 1996-12-24
EP0871668A4 (fr) 2000-01-05
WO1996039441A1 (fr) 1996-12-12
EP0871668A1 (fr) 1998-10-21

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead