CA2212113A1 - Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement - Google Patents

Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement

Info

Publication number
CA2212113A1
CA2212113A1 CA002212113A CA2212113A CA2212113A1 CA 2212113 A1 CA2212113 A1 CA 2212113A1 CA 002212113 A CA002212113 A CA 002212113A CA 2212113 A CA2212113 A CA 2212113A CA 2212113 A1 CA2212113 A1 CA 2212113A1
Authority
CA
Canada
Prior art keywords
surfactant
gas
gas emulsion
emulsion containing
contrast enhancement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002212113A
Other languages
French (fr)
Other versions
CA2212113C (en
Inventor
Leo A. Trevino
Ernest George Schutt
David H. Klein
Thomas E. Tarara
Jeffry G. Weers
Alexey Kabalnov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imcor Pharmaceutical Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2212113A1 publication Critical patent/CA2212113A1/en
Application granted granted Critical
Publication of CA2212113C publication Critical patent/CA2212113C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

Abstract

A gas emulsion forming composition comprising a dry, hollow, particulate, approximately microspherical material permeated with a gas or gas mixture, which upon dissolution in aqueous liquid forms a gas emulsion comprising a plurality of bubbles surrounded by a layer of at least a first and a second surfactant, wherein the first surfactant consists essentially of a phospholipid or mixture of phospholipids having at least one acyl chain which comprises at least 10 carbon atoms, and comprising at least about 5 % w/w of total surfactant, and wherein the second surfactant may or may not be a phospholipid and is more water soluble than the first surfactant; kits for preparing such microbubbles; and methods for using such microbubbles as contrast agents.
CA002212113A 1995-02-28 1996-02-15 Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement Expired - Fee Related CA2212113C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/395,680 US5798091A (en) 1993-07-30 1995-02-28 Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US08/395,680 1995-02-28
PCT/US1996/001922 WO1996026746A1 (en) 1995-02-28 1996-02-15 Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement

Publications (2)

Publication Number Publication Date
CA2212113A1 true CA2212113A1 (en) 1996-09-06
CA2212113C CA2212113C (en) 2007-04-24

Family

ID=23564039

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002212113A Expired - Fee Related CA2212113C (en) 1995-02-28 1996-02-15 Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement

Country Status (12)

Country Link
US (3) US5798091A (en)
EP (1) EP0812214A1 (en)
JP (2) JPH11501305A (en)
KR (1) KR100407755B1 (en)
CN (1) CN1182373B (en)
AU (1) AU731671B2 (en)
CA (1) CA2212113C (en)
FI (1) FI973496A (en)
HU (1) HUP9802095A3 (en)
NO (1) NO973489L (en)
PL (1) PL321952A1 (en)
WO (1) WO1996026746A1 (en)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU767705B2 (en) * 1995-02-28 2003-11-20 Photogen Technologies, Inc. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US6033645A (en) * 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
DE19602930A1 (en) * 1996-01-18 1997-07-24 Schering Ag Porous matrices made of low molecular weight substances for the generation of stable gas bubble suspensions, their use as ultrasound contrast agents and processes for their production
US5834519A (en) * 1996-10-11 1998-11-10 Wayne State University Stabilized gas-supersaturated emulsions and suspensions
MXPA99003664A (en) * 1996-10-21 2002-06-11 Nycomed Imaging As Improvements in or relating to contrast agents.
KR20000062319A (en) * 1996-12-24 2000-10-25 제닌 페트릭 Pesticidal 1-arylpyrazoles
GB9708240D0 (en) * 1997-04-23 1997-06-11 Nycomed Imaging As Improvements in or relating to contrast agents
JP4808842B2 (en) * 1997-08-18 2011-11-02 ジーイー・ヘルスケア・アクスイェ・セルスカプ Vesicle preparation method
GB9717542D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Process
GB9717588D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
ATE238035T1 (en) * 1997-09-29 2003-05-15 Inhale Therapeutic Syst PERFORATED MICROPARTICLES AND USE THEREOF
US20010003580A1 (en) * 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
DE19805012A1 (en) * 1998-02-07 1999-08-12 Thomas Gieselmann Contrast agent for use as a diagnostic agent in imaging processes and its production
US6391149B1 (en) * 1998-06-04 2002-05-21 Advanced Cardiovascular Systems, Inc. Method and apparatus for concentrating a solute in solution with a solvent
US6491929B1 (en) 1999-03-01 2002-12-10 The General Hospital Corporation Skin cosmetics
GB9912356D0 (en) * 1999-05-26 1999-07-28 Btg Int Ltd Generation of microfoam
AU6636000A (en) * 1999-08-13 2001-03-13 Point Biomedical Corporation Hollow microspheres with controlled fragility for medical use
US6210611B1 (en) * 1999-11-30 2001-04-03 Duke University Methods for producing gas microbubbles having lipid-containing shells formed thereon
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
TWI290473B (en) 2000-05-10 2007-12-01 Alliance Pharma Phospholipid-based powders for drug delivery
CA2410887C (en) 2000-06-02 2012-07-24 Bracco Research Usa Compounds for targeting endothelial cells, compositions containing the same and methods for their use
GB0028692D0 (en) * 2000-11-24 2001-01-10 Btg Int Ltd Generation of therapeutic microform
KR100373712B1 (en) * 2000-12-23 2003-02-25 사회복지법인삼성생명공익재단(삼성서울병원) Contrast agent and manufacturing method of same
JP3819845B2 (en) * 2001-04-06 2006-09-13 ブラッコ・リサーチ・ソシエテ・アノニム Improved method for measuring local physical parameters in fluid filled cavities
US8512680B2 (en) * 2001-08-08 2013-08-20 Btg International Ltd. Injectables in foam, new pharmaceutical applications
WO2003053411A1 (en) 2001-12-19 2003-07-03 Nektar Therapeutics Pulmonary delivery of aminoglycosides
US7923431B2 (en) * 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
EP1458425B1 (en) * 2001-12-21 2009-11-18 Ferrosan A/S A hemostatic kit, a method of preparing a hemostatic agent and a method of promoting hemostasis
FR2834636B1 (en) * 2002-01-15 2006-02-24 El Hassane Larhrib PROCESS FOR THE MANUFACTURE OF HOLLOW MICRO-POROUS PARTICLES, ESPECIALLY FOR INHALATION
US7794693B2 (en) * 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
EP2301587B1 (en) 2002-03-01 2014-06-25 Dyax Corp. KDR and VEGF/KDR binding peptides and their use in diagnosis
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
CA2513044A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
CA2509914A1 (en) * 2002-12-11 2004-06-24 Ferrosan A/S Gelatine-based materials as swabs
JP4670083B2 (en) * 2003-02-04 2011-04-13 ブラッコ・シュイス・ソシエテ・アノニム Ultrasonic contrast agent and method for producing the same
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
CA2517939C (en) 2003-03-03 2015-11-24 Dyax Corp. Peptides that specifically bind hgf receptor (cmet) and uses thereof
US8048439B2 (en) * 2003-11-17 2011-11-01 Btg International Ltd. Therapeutic foam
PT1694292E (en) * 2003-11-17 2009-10-26 Btg Int Ltd Therapeutic foam comprising a sclerosing solution and a low quanitiy of gaseous nitrogen
EP1701745B1 (en) * 2003-12-22 2014-12-10 Bracco Suisse S.A. Gas-filled microvesicle assembly for contrast imaging
CN1921896B (en) 2004-01-30 2010-11-24 弗罗桑公司 Haemostatic sprays and compositions
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
EP1786480B1 (en) 2004-07-09 2016-09-21 Ferrosan Medical Devices A/S Haemostatic composition comprising hyaluronic acid
WO2006018433A1 (en) 2004-08-18 2006-02-23 Bracco Research Sa Gas-filled microvesicles composition for contrast imaging
EP1655040A1 (en) * 2004-10-08 2006-05-10 Bracco Imaging, S.P.A. Contrast agent formulations for the visualization of the lymphatic system
GB0509824D0 (en) * 2005-05-13 2005-06-22 Btg Int Ltd Therapeutic foam
JP4485444B2 (en) * 2005-09-28 2010-06-23 シャープ株式会社 Waste water treatment method and waste water treatment equipment
US8257338B2 (en) * 2006-10-27 2012-09-04 Artenga, Inc. Medical microbubble generation
JP3974928B1 (en) * 2006-06-07 2007-09-12 シャープ株式会社 Waste water treatment method and waste water treatment equipment
US20090088393A1 (en) 2007-09-28 2009-04-02 Zomanex, Llc Methods and formulations for converting intravenous and injectable drugs into oral dosage forms
WO2009109194A2 (en) 2008-02-29 2009-09-11 Ferrosan A/S Device for promotion of hemostasis and/or wound healing
WO2011038043A1 (en) * 2009-09-22 2011-03-31 Targeson, Inc. Optical imaging contrast agents and uses therof
EP2345732A1 (en) 2010-01-19 2011-07-20 Universite Paris Descartes Methods for intracellular delivery of nucleic acids
PT2603238E (en) 2010-08-09 2014-10-22 Inserm Inst Nat De La Santé Et De La Rech Médicale Methods and pharmaceutical compositions for the treatment of an ocular disease in a subject
WO2012065060A2 (en) * 2010-11-12 2012-05-18 Children's Medical Center Corporation Gas-filled microbubbles and systems for gas delivery
RU2657955C2 (en) 2012-03-06 2018-06-18 Ферросан Медикал Дивайсиз А/С Pressurised container containing haemostatic paste
US10357450B2 (en) 2012-04-06 2019-07-23 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
CN104349827A (en) * 2012-04-30 2015-02-11 通用电气医疗集团股份有限公司 Method for filling container with foamable composition
AU2013275758B2 (en) 2012-06-12 2015-03-12 Ferrosan Medical Devices A/S Dry haemostatic composition
US10577554B2 (en) 2013-03-15 2020-03-03 Children's Medical Center Corporation Gas-filled stabilized particles and methods of use
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
KR101853948B1 (en) * 2013-07-05 2018-05-02 사회복지법인 삼성생명공익재단 Composition containing x-ray contrast and bubble accelerator and method for producing the same
WO2015086028A1 (en) 2013-12-11 2015-06-18 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
EP2962681A1 (en) 2014-07-03 2016-01-06 Swiss VX Venentherapie und Forschung GmbH Devices and methods for injectable vascular sclerofoams using a carrier made of human blood and uses thereof
EP3206726B1 (en) 2014-10-13 2020-05-27 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
RU2717356C2 (en) 2015-07-03 2020-03-23 Ферросан Медикал Дивайсиз А/С Syringe for holding vacuum in storage state
WO2018160752A1 (en) 2017-02-28 2018-09-07 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use
US11406722B2 (en) * 2017-03-16 2022-08-09 The Board Of Regents Of The University Of Texas System Nanodroplets with improved properties
WO2019215274A1 (en) 2018-05-09 2019-11-14 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition
KR102103810B1 (en) * 2018-05-24 2020-04-24 한국원자력의학원 Perfluorocarbon nanoparticle, ultrasonic contrast agent for drug delivery including the same, and a process for the preparation thereof

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4657756A (en) * 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
DE3141641A1 (en) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen ULTRASONIC CONTRAST AGENTS AND THEIR PRODUCTION
JPS5967229A (en) 1982-10-08 1984-04-16 Green Cross Corp:The Contrast medium for ultrasonic diagnosis
US4572203A (en) 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
DE3313947A1 (en) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
DE3324754A1 (en) * 1983-07-06 1985-01-17 Schering AG, 1000 Berlin und 4709 Bergkamen ULTRASONIC CONTRASTING AGENTS AND THEIR PRODUCTION
IT1198860B (en) 1984-06-08 1988-12-21 Mario Gonzi MICROTRAFILAMENT INTECEPTOR DEVICE, TO AVOID AND / OR REPORT OIL LEAKS IN HYDRAULIC SYSTEMS AND EQUIVALENT USES
US5186922A (en) * 1985-03-15 1993-02-16 See/Shell Biotechnology, Inc. Use of biodegradable microspheres labeled with imaging energy constrast materials
US4613326A (en) * 1985-07-12 1986-09-23 Becton, Dickinson And Company Two-component medication syringe assembly
DE3529195A1 (en) * 1985-08-14 1987-02-26 Max Planck Gesellschaft CONTRAST AGENTS FOR ULTRASONIC EXAMINATIONS AND METHOD FOR THE PRODUCTION THEREOF
US4684479A (en) * 1985-08-14 1987-08-04 Arrigo Joseph S D Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
WO1987002893A1 (en) * 1985-11-18 1987-05-21 Board Of Regents, The University Of Texas System Polychelating agents for image and spectral enhancement (and spectral shift)
US4640246A (en) 1986-01-03 1987-02-03 Sturdy Truck Equipment, Incorporated Road and engine speed governor with power demand control
US4927623A (en) * 1986-01-14 1990-05-22 Alliance Pharmaceutical Corp. Dissolution of gas in a fluorocarbon liquid
GB8601100D0 (en) * 1986-01-17 1986-02-19 Cosmas Damian Ltd Drug delivery system
US5684050A (en) * 1986-01-24 1997-11-04 Hemagen/Pfc Stable emulsions of highly fluorinated organic compounds
US5536753A (en) * 1986-01-24 1996-07-16 Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center And Hemagen/Pfc Stable perfluorocarbon and oil emulsions
ES2054658T3 (en) * 1986-01-24 1994-08-16 Childrens Hosp Medical Center METHOD FOR THE PREPARATION OF A PHYSIOLOGICALLY ACCEPTABLE EMULSION.
DE3637926C1 (en) 1986-11-05 1987-11-26 Schering Ag Ultrasonic manometry in a liquid using microbubbles
US4925678A (en) * 1987-04-01 1990-05-15 Ranney David F Endothelial envelopment drug carriers
US4781676A (en) * 1987-02-20 1988-11-01 Air Products And Chemicals, Inc. Interstitial administration of perfluorochemical emulsions for reoxygenation of hypoxic tumor cells
US5108759A (en) * 1987-04-01 1992-04-28 Ranney David F Endothelial envelopment drug carriers
DE3741201A1 (en) 1987-12-02 1989-06-15 Schering Ag ULTRASONIC PROCESS AND METHOD FOR IMPLEMENTING IT
DE3741199A1 (en) * 1987-12-02 1989-08-17 Schering Ag USE OF ULTRASONIC CONTRASTING AGENTS FOR ULTRASONIC LITHOTRIPSY
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
EP0586875A1 (en) 1988-02-05 1994-03-16 Schering Aktiengesellschaft Ultrasonic contrast agents, process for producing them and their use as diagnostic and therapeutic agents
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
DE3828905A1 (en) 1988-08-23 1990-03-15 Schering Ag MEDIALLY COMPOSED OF CAVITATE OR CLATHRATE MAKING HOST / GUEST COMPLEX AS A CONTRAST
DE3829999A1 (en) 1988-09-01 1990-03-15 Schering Ag ULTRASONIC METHOD AND CIRCUITS THEREOF
US5410516A (en) 1988-09-01 1995-04-25 Schering Aktiengesellschaft Ultrasonic processes and circuits for performing them
NL8802219A (en) * 1988-09-09 1990-04-02 Philips Nv METHOD FOR MANUFACTURING A SILICON BODY SEMICONDUCTOR DEVICE CONTAINING SEMICON IMPLANTS FOR SEMICONDUCTOR AREAS.
US4957656A (en) 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
US5773024A (en) 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5334381A (en) * 1989-12-22 1994-08-02 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US6088613A (en) * 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5705187A (en) 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5228446A (en) * 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
GB9003821D0 (en) * 1990-02-20 1990-04-18 Danbiosyst Uk Diagnostic aid
IN172208B (en) 1990-04-02 1993-05-01 Sint Sa
US5556610A (en) * 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
GB9009423D0 (en) * 1990-04-26 1990-06-20 Williams Alun R Assessment of vascular perfusion by the display of harmonic echoes from ultrasonically excited gas bubbles
US5190982A (en) 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5315997A (en) * 1990-06-19 1994-05-31 Molecular Biosystems, Inc. Method of magnetic resonance imaging using diamagnetic contrast
JP2599492B2 (en) * 1990-08-21 1997-04-09 第一製薬株式会社 Manufacturing method of liposome preparation
US5310540A (en) * 1990-10-05 1994-05-10 Sintetica Sa Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
DE4100470A1 (en) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echo contrast agent
DE69215722T3 (en) * 1991-03-22 2001-03-08 Katsuro Tachibana Amplifiers for ultrasound therapy of diseases and liquid pharmaceutical compositions containing them
GB9106673D0 (en) 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106686D0 (en) 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
EP0586524B2 (en) * 1991-06-03 2000-11-02 Nycomed Imaging As Improvements in or relating to contrast agents
DK0593624T3 (en) * 1991-07-05 1997-05-20 Nycomed Imaging As Improvements to or in relation to contrast agents
GB9115324D0 (en) 1991-07-16 1991-08-28 Ici Plc Rodenticide bait package
GB9116610D0 (en) * 1991-08-01 1991-09-18 Danbiosyst Uk Preparation of microparticles
WO1993003671A1 (en) * 1991-08-13 1993-03-04 Molecular Biosystem, Inc. Method of mri imaging using diamagnetic contrast agents
NZ244147A (en) 1991-09-03 1994-09-27 Hoechst Ag Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
DE605477T1 (en) * 1991-09-17 1998-09-24 Sonus Pharma Inc GASEOUS ULTRASONIC CONTRASTING AGENTS AND METHOD FOR SELECTING GASES FOR USE AS ULTRASONIC CONTRASTING AGENTS.
MX9205298A (en) * 1991-09-17 1993-05-01 Steven Carl Quay GASEOUS ULTRASOUND CONTRASTING MEDIA AND METHOD FOR SELECTING GASES TO BE USED AS ULTRASOUND CONTRASTING MEDIA
AU2789192A (en) * 1991-10-04 1993-05-03 Mallinckrodt Medical, Inc. Gaseous ultrasound contrast agents
US5196183A (en) * 1991-12-04 1993-03-23 Sterling Winthrop Inc. Contrast agents for ultrasound imaging
US5255683A (en) * 1991-12-30 1993-10-26 Sound Science Limited Partnership Methods of and systems for examining tissue perfusion using ultrasonic contrast agents
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
DE4219723A1 (en) * 1992-06-13 1993-12-16 Schering Ag Microparticles, processes for their production and their use in diagnostics
AU4563093A (en) * 1992-07-03 1994-01-31 Byk Gulden Lomberg Chemische Fabrik Gmbh Echographic contrast agent composition
WO1994006477A1 (en) * 1992-09-16 1994-03-31 Holmes, Michael, John Improvements in or relating to contrast agents
US5314644A (en) * 1992-10-19 1994-05-24 Virginia Polytechnic Institute And State University Microbubble generator
JPH08502979A (en) * 1992-11-02 1996-04-02 ドレクセル ユニバーシティー Surfactant-stabilized microbubble mixture, process for its production and use thereof
US5393527A (en) * 1993-01-04 1995-02-28 Becton, Dickinson And Company Stabilized microspheres and methods of preparation
DE69427185T2 (en) * 1993-01-25 2001-12-06 Sonus Pharma Inc Phase-pen colloids for use as ultrasound contrast agents
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
IL108367A0 (en) 1993-01-27 1994-04-12 Hektoen Inst For Medical Resea Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells
US5333613A (en) * 1993-03-23 1994-08-02 Delineate Microparticles as ultrasonic contrast media
US5716597A (en) 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
KR100218642B1 (en) 1993-07-02 1999-09-01 스티븐 로손 Method of making microspheres encapsulated from the temperature-denaturated protein
US5558092A (en) 1995-06-06 1996-09-24 Imarx Pharmaceutical Corp. Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously

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US7141235B2 (en) 2006-11-28
CA2212113C (en) 2007-04-24
JPH11501305A (en) 1999-02-02
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KR19980702548A (en) 1998-07-15
CN1182373A (en) 1998-05-20
US20020031476A1 (en) 2002-03-14
MX9706402A (en) 1998-08-30
AU4922196A (en) 1996-09-18
EP0812214A1 (en) 1997-12-17
NO973489D0 (en) 1997-07-30
HUP9802095A2 (en) 1999-01-28
HUP9802095A3 (en) 1999-03-29
FI973496A0 (en) 1997-08-26
PL321952A1 (en) 1998-01-05
CN1182373B (en) 2010-12-08
JP4229918B2 (en) 2009-02-25
US6280705B1 (en) 2001-08-28
US5798091A (en) 1998-08-25
FI973496A (en) 1997-08-26
WO1996026746A1 (en) 1996-09-06
JP2005263804A (en) 2005-09-29
AU731671B2 (en) 2001-04-05

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