CA2203844A1 - Procede d'isolement du paclitaxel et de la 9-dihydro-13-acetylbaccatine iii - Google Patents

Procede d'isolement du paclitaxel et de la 9-dihydro-13-acetylbaccatine iii

Info

Publication number: CA2203844A1
Authority: CA; Canada
Prior art keywords: dihydro; paclitaxel; isolation; acetylbaccatin iii; extract
Prior art date: 1997-04-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA 2203844

Other languages

English (en)

Other versions

CA2203844C (fr

Inventor

Jian Liu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ivax Research Holdings Inc

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-28

Filing date

1997-04-28

Publication date

1998-10-28

1997-04-28 Application filed by Individual filed Critical Individual

1997-04-28 Priority to CA 2203844 priority Critical patent/CA2203844C/fr

1998-10-28 Publication of CA2203844A1 publication Critical patent/CA2203844A1/fr

2004-01-27 Application granted granted Critical

2004-01-27 Publication of CA2203844C publication Critical patent/CA2203844C/fr

2017-04-28 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

WPPPFZJNKLMYBW-FAEUQDRCSA-N 13-acetyl-9-dihydrobaccatin iii Chemical compound O([C@@H]1[C@]2(O)C[C@@H](C(=C([C@@H](OC(C)=O)[C@H](O)[C@]3(C)[C@@H](O)C[C@H]4OC[C@]4([C@H]31)OC(C)=O)C2(C)C)C)OC(=O)C)C(=O)C1=CC=CC=C1 WPPPFZJNKLMYBW-FAEUQDRCSA-N 0.000 title abstract 2
FFCWRLFQIKDRNO-UHFFFAOYSA-N 9-dihydro-13-acetyl baccatin III Natural products CC(=O)OC1C2C(O)CC(OC(=O)C)C3(CO3)C2C(OC(=O)C)C4(O)CC(OC(=O)C)C(=C(C1OC(=O)C)C4(C)C)C FFCWRLFQIKDRNO-UHFFFAOYSA-N 0.000 title abstract 2
229930012538 Paclitaxel Natural products 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
229960001592 paclitaxel Drugs 0.000 title abstract 2
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 2
238000002955 isolation Methods 0.000 title 1
229940123237 Taxane Drugs 0.000 abstract 1
241001116500 Taxus Species 0.000 abstract 1
238000004440 column chromatography Methods 0.000 abstract 1
239000000287 crude extract Substances 0.000 abstract 1
239000000284 extract Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA 2203844 1997-04-28 1997-04-28 Procede d'isolement du paclitaxel et de la 9-dihydro-13-acetylbaccatine iii Expired - Fee Related CA2203844C (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA 2203844 CA2203844C (fr)	1997-04-28	1997-04-28	Procede d'isolement du paclitaxel et de la 9-dihydro-13-acetylbaccatine iii

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA 2203844 CA2203844C (fr)	1997-04-28	1997-04-28	Procede d'isolement du paclitaxel et de la 9-dihydro-13-acetylbaccatine iii

Publications (2)

Publication Number	Publication Date
CA2203844A1 true CA2203844A1 (fr)	1998-10-28
CA2203844C CA2203844C (fr)	2004-01-27

Family

ID=29274791

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA 2203844 Expired - Fee Related CA2203844C (fr)	1997-04-28	1997-04-28	Procede d'isolement du paclitaxel et de la 9-dihydro-13-acetylbaccatine iii

Country Status (1)

Country	Link
CA (1)	CA2203844C (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001066535A1 (fr) *	2000-03-10	2001-09-13	Baker Norton Pharmaceuticals, Inc.	Procede permettant la preparation de paclitaxel et de 13-acetyl-9-dihydrobaccatine iii
US6878832B2 (en)	2000-11-13	2005-04-12	Lahu Saiji	Isolation of taxanes
AU2006201733B2 (en) *	2000-03-10	2007-05-24	Ivax Research, Inc.	Process for manufacturing paclitaxel and 13-acetyl-9-dihydrobaccatin III
CN1328269C (zh) *	2004-03-18	2007-07-25	中国科学院大连化学物理研究所	一种紫杉醇的制备方法
CN103588736A (zh) *	2013-12-03	2014-02-19	云南汉德生物技术有限公司	13-乙酰基-9-羟基巴卡亭iii的提取分离方法

1997
- 1997-04-28 CA CA 2203844 patent/CA2203844C/fr not_active Expired - Fee Related

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001066535A1 (fr) *	2000-03-10	2001-09-13	Baker Norton Pharmaceuticals, Inc.	Procede permettant la preparation de paclitaxel et de 13-acetyl-9-dihydrobaccatine iii
AU2006201733B2 (en) *	2000-03-10	2007-05-24	Ivax Research, Inc.	Process for manufacturing paclitaxel and 13-acetyl-9-dihydrobaccatin III
US6878832B2 (en)	2000-11-13	2005-04-12	Lahu Saiji	Isolation of taxanes
CN1328269C (zh) *	2004-03-18	2007-07-25	中国科学院大连化学物理研究所	一种紫杉醇的制备方法
CN103588736A (zh) *	2013-12-03	2014-02-19	云南汉德生物技术有限公司	13-乙酰基-9-羟基巴卡亭iii的提取分离方法

Also Published As

Publication number	Publication date
CA2203844C (fr)	2004-01-27

Similar Documents

Publication	Publication Date	Title
AU5115593A (en)	1994-04-26	Method of obtaining 10-deacetylbaccatine iii
CA2130745A1 (fr)	1993-09-02	Production amelioree de taxol et de taxanes grace a la culture de cellules de l'espece taxus
AU1888792A (en)	1992-11-17	Methods and compositions for isolating taxanes
AU5115493A (en)	1994-04-26	Method of obtaining 10-deacetylbaccatine iii
HK1040981A1 (en)	2002-06-28	id as well as solvent for its extraction from the Microbial process for the preparation of acetic acfermentation broth
FI931680A0 (fi)	1993-04-14	Foerbaettrat foerfarande foer syntetisering av (4r-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioxan-4-acetat
DE69533793D1 (de)	2004-12-30	Lösungsmittel-extraktionsverfahren
Schlingmann et al.	1998	New α-pyrones produced by fungal culture LL-11G219 function as androgen receptor ligands
AU2002313702A1 (en)	2003-02-17	Process for isolating phenolic compounds
PL327458A1 (en)	1998-12-07	Intermediate compounds for hemisynthesis if taxanes and method of obtaining them
Kimura et al.	1996	Aspyrone, a nematicidal compound isolated from the fungus, Aspergillus melleus
BR9916621A (pt)	2001-10-30	Processo para extração de alto rendimento depaclitaxel de material contendo paclitaxel
CA2203844A1 (fr)	1998-10-28	Procede d'isolement du paclitaxel et de la 9-dihydro-13-acetylbaccatine iii
WO2001051476A3 (fr)	2002-01-17	Production de paclitaxel et de taxanes
EP1010697A3 (fr)	2000-07-19	Procédé pour l'isolation de 14-b hydroxy-10-désacétyl Baccatin III
EP0861838A3 (fr)	1998-12-09	Procédés et intermédiaires pour la préparation de composés de cryptophycine
CO5271695A1 (es)	2003-04-30	Proceso para preparar placlitaxel y 13-acetil-9- dihidrobacatin iii
GB2365442B (en)	2004-03-03	Process for the removal of organic interfering components from an aplha-olefin crude product
MX9802429A (es)	1998-10-31	Proceso para la supresion de polvos en solidos.
FR2736355B1 (fr)	1997-11-07	Procede d'extraction et d'isolement de la 10-desacetylbaccatine iii
KR100213666B1 (en)	1999-08-02	Process for the extraction of taxol from the leaves of taxus cuspidata
CA2108265A1 (fr)	1992-10-20	Methodes et compositions pour l'isolement de taxanes
RU94025291A (ru)	1996-05-10	Способ получения авермектина
RU92015333A (ru)	1995-02-10	Способ получения средства, обладающего противолучевой активностью, из стручкового перца (capsicum annuum l)
IT1270825B (it)	1997-05-13	Procedimento per la preparazione di lipo-nucleotidi fosfatidilici

Legal Events

Date	Code	Title	Description
1999-04-27	EEER	Examination request
2010-04-28	MKLA	Lapsed