CA2194168A1 - Improved bioadhesive pharmaceutical delivery system - Google Patents

Improved bioadhesive pharmaceutical delivery system

Info

Publication number
CA2194168A1
CA2194168A1 CA002194168A CA2194168A CA2194168A1 CA 2194168 A1 CA2194168 A1 CA 2194168A1 CA 002194168 A CA002194168 A CA 002194168A CA 2194168 A CA2194168 A CA 2194168A CA 2194168 A1 CA2194168 A1 CA 2194168A1
Authority
CA
Canada
Prior art keywords
delivery system
phase
pharmaceutical delivery
bioadhesive pharmaceutical
volume
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002194168A
Other languages
French (fr)
Other versions
CA2194168C (en
Inventor
Robert C. Cuca
Keith S. Lienhop
Thomas Charles Riley, Jr.
R. Saul Levinson
Mitchell I. Kirschner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kv Pharmaceutical Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/441,297 external-priority patent/US5554380A/en
Application filed by Individual filed Critical Individual
Publication of CA2194168A1 publication Critical patent/CA2194168A1/en
Application granted granted Critical
Publication of CA2194168C publication Critical patent/CA2194168C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays

Abstract

A solid or semi-solid bioadherent, orally ingestible drug delivery system containing a water-in-coil system having at least two phases, one phase comprises from about 25 % to about 75 % by volume of an internal hydrophilic phase and the other phase comprises from about 25 % to to about 75 % by volume of an external hydrophobic phase wherein the external hydrophobic phase is comprised of three components: a) an emulsifier, b) a glyceride ester and c) a wax material.
CA002194168A 1994-08-04 1995-07-31 Improved bioadhesive pharmaceutical delivery system Expired - Lifetime CA2194168C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28390494A 1994-08-04 1994-08-04
US08/283,904 1994-08-04
US08/441,297 1995-05-15
US08/441,297 US5554380A (en) 1994-08-04 1995-05-15 Bioadhesive pharmaceutical delivery system
PCT/US1995/009483 WO1996003975A1 (en) 1994-08-04 1995-07-31 Improved bioadhesive pharmaceutical delivery system

Publications (2)

Publication Number Publication Date
CA2194168A1 true CA2194168A1 (en) 1996-02-15
CA2194168C CA2194168C (en) 2007-04-10

Family

ID=38007169

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002194168A Expired - Lifetime CA2194168C (en) 1994-08-04 1995-07-31 Improved bioadhesive pharmaceutical delivery system

Country Status (1)

Country Link
CA (1) CA2194168C (en)

Also Published As

Publication number Publication date
CA2194168C (en) 2007-04-10

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20150731