CA2187153A1 - Effervescent pharmaceutical formulations containing controlled release biodegradable microcapsules - Google Patents

Effervescent pharmaceutical formulations containing controlled release biodegradable microcapsules

Info

Publication number
CA2187153A1
CA2187153A1 CA002187153A CA2187153A CA2187153A1 CA 2187153 A1 CA2187153 A1 CA 2187153A1 CA 002187153 A CA002187153 A CA 002187153A CA 2187153 A CA2187153 A CA 2187153A CA 2187153 A1 CA2187153 A1 CA 2187153A1
Authority
CA
Canada
Prior art keywords
drug
pharmaceutical formulations
formulation
controlled release
microcapsules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002187153A
Other languages
French (fr)
Other versions
CA2187153C (en
Inventor
Virginia Freeman
Zebunnissa Ramtoola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Corp PLC
Original Assignee
Virginia Freeman
Zebunnissa Ramtoola
Elan Corporation, Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IE940292A external-priority patent/IE940292A1/en
Application filed by Virginia Freeman, Zebunnissa Ramtoola, Elan Corporation, Plc filed Critical Virginia Freeman
Publication of CA2187153A1 publication Critical patent/CA2187153A1/en
Application granted granted Critical
Publication of CA2187153C publication Critical patent/CA2187153C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Effervescent pharmaceutical formulations for the sustained and controlled oral administration of a drug selected from a calcium channel blocker, an ACE inhibitor, a narcotic analgesic or analogues or combinations thereof, the formulation comprising microcapsules in which the drug is entrapped in a biodegradable polymer, for example poly-L lactide. The pH of the formulation can be varied to optimize the release of the or each drug from the formulation. Microcapsules suitably have a D 50 % between about 100 nm and 900 nm and a drug loading of the order of about 10 % to 70 % by weight.
The formulations can be used to administer the drugs to a patient on a once-daily basis so as to achieve a therapeutic effect over a substantially 24-hour period.
CA002187153A 1994-04-06 1995-04-06 Effervescent pharmaceutical formulations containing controlled release biodegradable microcapsules Expired - Fee Related CA2187153C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IE940292A IE940292A1 (en) 1994-04-06 1994-04-06 Biodegradable microcapsules and method for their manufacture
IE940292 1994-04-06
PCT/IE1995/000025 WO1995027482A1 (en) 1994-04-06 1995-04-06 Effervescent pharmaceutical formulations containing controlled release biodegradable microcapsules

Publications (2)

Publication Number Publication Date
CA2187153A1 true CA2187153A1 (en) 1995-10-19
CA2187153C CA2187153C (en) 2007-03-06

Family

ID=37891549

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002187153A Expired - Fee Related CA2187153C (en) 1994-04-06 1995-04-06 Effervescent pharmaceutical formulations containing controlled release biodegradable microcapsules

Country Status (1)

Country Link
CA (1) CA2187153C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ308409B6 (en) * 2013-02-26 2020-08-05 Elmarco S.R.O. Preparation for the administration of at least one biologically and / or pharmaceutically active substance

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ308409B6 (en) * 2013-02-26 2020-08-05 Elmarco S.R.O. Preparation for the administration of at least one biologically and / or pharmaceutically active substance

Also Published As

Publication number Publication date
CA2187153C (en) 2007-03-06

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed