CA2182417A1 - Oral dosage form containing colestipol as a carrier and acidic active substances and a process for producing the same - Google Patents

Oral dosage form containing colestipol as a carrier and acidic active substances and a process for producing the same

Info

Publication number
CA2182417A1
CA2182417A1 CA002182417A CA2182417A CA2182417A1 CA 2182417 A1 CA2182417 A1 CA 2182417A1 CA 002182417 A CA002182417 A CA 002182417A CA 2182417 A CA2182417 A CA 2182417A CA 2182417 A1 CA2182417 A1 CA 2182417A1
Authority
CA
Canada
Prior art keywords
carrier
producing
dosage form
same
active substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002182417A
Other languages
French (fr)
Other versions
CA2182417C (en
Inventor
Walter Muller
Karsten Cremer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2182417A1 publication Critical patent/CA2182417A1/en
Application granted granted Critical
Publication of CA2182417C publication Critical patent/CA2182417C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

An oral administration form with a carrier for acid active sub-stances wherein the active substance has at least one free car-boxyl group ionically bound to a polymer having tertiary amino groups is characterized by the fact that the polymer is colestipol or colestipol hydrochloride.
CA002182417A 1994-01-27 1994-12-08 Oral dosage form containing colestipol as a carrier and acidic active substances and a process for producing the same Expired - Fee Related CA2182417C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4402379A DE4402379C2 (en) 1994-01-27 1994-01-27 Oral dosage form with acidic active ingredients and process for their preparation
DEP4402379.0 1994-01-27
PCT/EP1994/004082 WO1995020394A1 (en) 1994-01-27 1994-12-08 Oral dosage form containing colestipol as a carrier and acidic active substances and a process for producing the same

Publications (2)

Publication Number Publication Date
CA2182417A1 true CA2182417A1 (en) 1995-08-03
CA2182417C CA2182417C (en) 2007-04-17

Family

ID=6508812

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002182417A Expired - Fee Related CA2182417C (en) 1994-01-27 1994-12-08 Oral dosage form containing colestipol as a carrier and acidic active substances and a process for producing the same

Country Status (22)

Country Link
US (1) US5858344A (en)
EP (1) EP0741574B1 (en)
JP (1) JP3701971B2 (en)
KR (1) KR100439311B1 (en)
AT (1) ATE218371T1 (en)
AU (1) AU697353B2 (en)
CA (1) CA2182417C (en)
CZ (1) CZ291006B6 (en)
DE (2) DE4402379C2 (en)
DK (1) DK0741574T3 (en)
ES (1) ES2177622T3 (en)
FI (1) FI116880B (en)
HU (1) HU223317B1 (en)
IL (1) IL112435A (en)
MY (1) MY113340A (en)
NO (1) NO963143L (en)
NZ (1) NZ277777A (en)
PL (1) PL315619A1 (en)
PT (1) PT741574E (en)
SK (1) SK97296A3 (en)
WO (1) WO1995020394A1 (en)
ZA (1) ZA95638B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403367B1 (en) * 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
DE19615820A1 (en) * 1996-04-06 1997-10-09 Holger Specht Dental care products containing orally absorbable components
US20030180249A1 (en) * 2002-03-18 2003-09-25 Khanna Satish Chandra Dosage forms for hygroscopic active ingredients
CN101534656B (en) 2006-11-07 2013-05-22 宝洁公司 Fiber containing compositions and methods of making and using same
US7767248B2 (en) * 2007-02-02 2010-08-03 Overly Iii Harry J Soft chew confectionary with high fiber and sugar content and method for making same
KR20240016997A (en) 2021-06-07 2024-02-06 고쿠리쯔 다이가쿠 호징 츠쿠바 다이가쿠 Polymerized valproic acid and its uses

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ191762A (en) * 1978-10-19 1982-09-14 Merck & Co Inc Hypocholesteremic composition containing cholesterol synthesis inhibitor and anion exchange resin
US4221778A (en) * 1979-01-08 1980-09-09 Pennwalt Corporation Prolonged release pharmaceutical preparations
EP0087864B1 (en) * 1982-03-01 1986-10-15 Efamol Limited Pharmaceutical composition
US4996047A (en) * 1988-11-02 1991-02-26 Richardson-Vicks, Inc. Sustained release drug-resin complexes
EP0409432A3 (en) * 1989-07-20 1991-12-11 Warner-Lambert Company Confectionery delivery system
CA2040865C (en) * 1990-05-15 2002-07-23 James L. Bergey Method for preventing, stabilizing or causing regression of atherosclerosis employing a combination of a cholesterol lowering drug and an ace inhibitor

Also Published As

Publication number Publication date
DE4402379C2 (en) 1997-09-25
PL315619A1 (en) 1996-11-25
FI116880B (en) 2006-03-31
HUT74434A (en) 1996-12-30
FI962985A (en) 1996-07-26
ZA95638B (en) 1995-10-25
DK0741574T3 (en) 2002-09-23
JPH09511488A (en) 1997-11-18
IL112435A (en) 1999-01-26
EP0741574A1 (en) 1996-11-13
NO963143D0 (en) 1996-07-26
IL112435A0 (en) 1995-03-30
EP0741574B1 (en) 2002-06-05
WO1995020394A1 (en) 1995-08-03
HU223317B1 (en) 2004-05-28
DE4402379A1 (en) 1995-08-03
US5858344A (en) 1999-01-12
CZ291006B6 (en) 2002-11-13
NZ277777A (en) 1997-01-29
AU1312795A (en) 1995-08-15
NO963143L (en) 1996-09-24
FI962985A0 (en) 1996-07-26
ES2177622T3 (en) 2002-12-16
JP3701971B2 (en) 2005-10-05
KR100439311B1 (en) 2005-08-17
SK97296A3 (en) 1997-04-09
HU9602041D0 (en) 1996-09-30
AU697353B2 (en) 1998-10-01
DE59410133D1 (en) 2002-07-11
KR970700505A (en) 1997-02-12
MY113340A (en) 2002-01-31
CZ221396A3 (en) 1997-01-15
ATE218371T1 (en) 2002-06-15
CA2182417C (en) 2007-04-17
PT741574E (en) 2002-11-29

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20121210