CA2172490A1 - Facteurs de reconnaissance d'un recepteur; sequences proteiniques et methodes d'utilisation - Google Patents

Facteurs de reconnaissance d'un recepteur; sequences proteiniques et methodes d'utilisation

Info

Publication number
CA2172490A1
CA2172490A1 CA002172490A CA2172490A CA2172490A1 CA 2172490 A1 CA2172490 A1 CA 2172490A1 CA 002172490 A CA002172490 A CA 002172490A CA 2172490 A CA2172490 A CA 2172490A CA 2172490 A1 CA2172490 A1 CA 2172490A1
Authority
CA
Canada
Prior art keywords
leu
glu
gln
ser
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002172490A
Other languages
English (en)
Inventor
James E. Darnell, Jr.
Christian W. Schindler
Ke Shuai
Zilong Wen
Zhong Zhong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockefeller University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/212,185 external-priority patent/US6605442B1/en
Application filed by Individual filed Critical Individual
Publication of CA2172490A1 publication Critical patent/CA2172490A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Il existe des facteurs de reconnaissance de récepteurs qui reconnaissent le récepteur cellulaire spécifique auquel un ligand spécifique a été fixé, et qui peuvent par conséquent signaler et/ou amorcer la fixation du facteur de transcription au site d'ADN. Le facteur de reconnaissance de récepteurs est dans un cas, une partie d'un facteur de transcription, et peut également avoir une interaction avec d'autres facteurs de transcription afin de provoquer leur activation et leur déplacement jusqu'au noyau pour fixer l'ADN. Le facteur de reconnaissance de récepteurs semble avoir une activité indépendante du second messager, puisque des perturbations manifestes dans des concentrations de second messager n'ont aucun effet. Le concept de l'invention est illustré par les résultats d'études menées avec une transcription de gènes stimulés par interféron (IFN), et notamment, l'activation provoquée par les interférons à la fois IFN alpha et IFN gamma . L'invention concerne également de l'ADN ainsi que des séquences d'acides aminés spécifiques à divers facteurs de reconnaissance des récepteurs humains et murins, ainsi que des fragments polypeptidiques de deux des gènes ISGF-3, des anticorps ayant également été préparés et testés. Les polypeptides confirment une implication directe de la tyrosine kinase dans la transmission du message intracellulaire. De plus l'invention concerne de nombreuses matières et applications diagnostiques et thérapeutiques.
CA002172490A 1993-09-24 1994-09-26 Facteurs de reconnaissance d'un recepteur; sequences proteiniques et methodes d'utilisation Abandoned CA2172490A1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US12658893A 1993-09-24 1993-09-24
US12659593A 1993-09-24 1993-09-24
US08/126,588 1993-09-24
US08/126,595 1993-09-24
US21218494A 1994-03-11 1994-03-11
US08/212,185 1994-03-11
US08/212,184 1994-03-11
US08/212,185 US6605442B1 (en) 1992-03-19 1994-03-11 Methods of testing drugs or agents that modulate the activity of receptor recognition factors

Publications (1)

Publication Number Publication Date
CA2172490A1 true CA2172490A1 (fr) 1995-03-30

Family

ID=27494654

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002172490A Abandoned CA2172490A1 (fr) 1993-09-24 1994-09-26 Facteurs de reconnaissance d'un recepteur; sequences proteiniques et methodes d'utilisation

Country Status (5)

Country Link
EP (1) EP0720652A1 (fr)
JP (1) JPH09506243A (fr)
AU (1) AU8072194A (fr)
CA (1) CA2172490A1 (fr)
WO (1) WO1995008629A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0676469A3 (fr) * 1994-04-04 1998-03-25 Tadamitsu Kishimoto Facteur de transcription APRF
US5639858A (en) * 1995-03-22 1997-06-17 Tularik, Inc. Human signal transducer and binding assays
US6030780A (en) * 1996-10-15 2000-02-29 The Rockefeller University Purified Stat proteins and methods of purifying thereof
US6720154B1 (en) 1997-10-15 2004-04-13 The Rockefeller University Purified stat proteins and methods of purifying thereof
EP0905234A3 (fr) 1997-09-16 1999-06-23 Applied Research Systems Ars Holding N.V. Allèles de la protéine STAT3 humaine
EP0906953A1 (fr) * 1997-09-16 1999-04-07 Applied Research Systems Ars Holding N.V. Allèles de la protéine STAT3 humaine
US6087478A (en) * 1998-01-23 2000-07-11 The Rockefeller University Crystal of the N-terminal domain of a STAT protein and methods of use thereof
US6391572B1 (en) 1999-08-31 2002-05-21 The Rockefeller University Methods for identifying modulators of transcriptional activator protein interactions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008740A2 (fr) * 1990-11-14 1992-05-29 The Rockefeller University Facteur de reconnaissance de recepteurs et procedes d'utilisation d'un tel facteur
EP0637333A1 (fr) * 1992-03-19 1995-02-08 The Rockefeller University Facteurs de reconnaissance de recepteurs d'interferon, sequences de proteines et leurs procedes d'utilisation

Also Published As

Publication number Publication date
EP0720652A1 (fr) 1996-07-10
JPH09506243A (ja) 1997-06-24
AU8072194A (en) 1995-04-10
WO1995008629A1 (fr) 1995-03-30

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead