CA2162670A1 - High dose formulations of mycophenolate mofetil, mycophenolic acid and ranolazine - Google Patents

High dose formulations of mycophenolate mofetil, mycophenolic acid and ranolazine

Info

Publication number
CA2162670A1
CA2162670A1 CA002162670A CA2162670A CA2162670A1 CA 2162670 A1 CA2162670 A1 CA 2162670A1 CA 002162670 A CA002162670 A CA 002162670A CA 2162670 A CA2162670 A CA 2162670A CA 2162670 A1 CA2162670 A1 CA 2162670A1
Authority
CA
Canada
Prior art keywords
ranolazine
high dose
mycophenolic acid
mycophenolate mofetil
dose formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002162670A
Other languages
French (fr)
Other versions
CA2162670C (en
Inventor
Glenn J. Samuels
Jung-Chung Lee
Charles Lee
Stephen Berry
Paul J. Jarosz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Glenn J. Samuels
Jung-Chung Lee
Charles Lee
Stephen Berry
Paul J. Jarosz
Syntex (U.S.A.) Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/061,656 external-priority patent/US5455045A/en
Application filed by Glenn J. Samuels, Jung-Chung Lee, Charles Lee, Stephen Berry, Paul J. Jarosz, Syntex (U.S.A.) Inc. filed Critical Glenn J. Samuels
Publication of CA2162670A1 publication Critical patent/CA2162670A1/en
Application granted granted Critical
Publication of CA2162670C publication Critical patent/CA2162670C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Mycophenolate mofetil, mycophenolic acid, and ranolazine can be conveniently manufactured into high dose oral formulations by the hot melt filling of a supercooled mycophenolate mofetil, mycophenolic acid, or ranolazine liquid into a pharmaceutical dosage form. High dose oral pharmaceutical formulations and manufacturing methods therefor are disclosed.
CA002162670A 1993-05-13 1994-05-10 High dose formulations of mycophenolate mofetil, mycophenolic acid and ranolazine Expired - Lifetime CA2162670C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/061,656 US5455045A (en) 1993-05-13 1993-05-13 High dose formulations
US061,656 1993-05-13
PCT/US1994/005196 WO1994026266A1 (en) 1993-05-13 1994-05-10 High dose formulations

Publications (2)

Publication Number Publication Date
CA2162670A1 true CA2162670A1 (en) 1994-11-24
CA2162670C CA2162670C (en) 2006-12-12

Family

ID=37561028

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002162670A Expired - Lifetime CA2162670C (en) 1993-05-13 1994-05-10 High dose formulations of mycophenolate mofetil, mycophenolic acid and ranolazine

Country Status (1)

Country Link
CA (1) CA2162670C (en)

Also Published As

Publication number Publication date
CA2162670C (en) 2006-12-12

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20140512