CA2137755A1 - Palliation of sickle cell disorders by phenylurea, benzylurea, or phenylethylurea or by a homolog ring-substituted with one methoxyl, methyl, or hydroxyl radical - Google Patents
Palliation of sickle cell disorders by phenylurea, benzylurea, or phenylethylurea or by a homolog ring-substituted with one methoxyl, methyl, or hydroxyl radicalInfo
- Publication number
- CA2137755A1 CA2137755A1 CA 2137755 CA2137755A CA2137755A1 CA 2137755 A1 CA2137755 A1 CA 2137755A1 CA 2137755 CA2137755 CA 2137755 CA 2137755 A CA2137755 A CA 2137755A CA 2137755 A1 CA2137755 A1 CA 2137755A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- phenylethylurea
- benzylurea
- phenylurea
- palliation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
This invention is directed to the novel use of arylurea compounds and aralkylura compounds consisting of phenylurea, benzylurea, and phenylethylurea or by a meta-or para-positioned, ring-substituted homolog of each in which one hydrogen is substituted by one methoxyl, methyl, or hydroxyl radical, for the palliation of sickle cell anemia and other human sickling disease.
The invention is also directed to pharmaceutical formulations containing these aromatic urea compounds.
The invention is also directed to pharmaceutical formulations containing these aromatic urea compounds.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25575594A | 1994-06-07 | 1994-06-07 | |
US08/255,755 | 1994-06-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2137755A1 true CA2137755A1 (en) | 1995-12-08 |
CA2137755C CA2137755C (en) | 2002-07-02 |
Family
ID=22969714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2137755 Expired - Fee Related CA2137755C (en) | 1994-06-07 | 1994-12-09 | Palliation of sickle cell disorders by phenylurea, benzylurea, or phenylethylurea or by a homolog ring-substituted with one methoxyl, methyl, or hydroxyl radical |
Country Status (2)
Country | Link |
---|---|
CA (1) | CA2137755C (en) |
GB (1) | GB2290235B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6696475B2 (en) | 1997-04-22 | 2004-02-24 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
AP2001002103A0 (en) * | 1998-10-22 | 2001-03-31 | Neurosearch As | Substituted phenyl derivatives, their preparation and use. |
DE102012007558A1 (en) | 2012-04-14 | 2013-10-17 | Alf Hammes | Use of diarylurea-derivatives for treating the symptoms of anemia, thalassemia, sickle cell anemia and Diamond-Blackfan anemia |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56131516A (en) * | 1980-03-18 | 1981-10-15 | Koutaku Hayashi | Immunochemotherapy, prevention of resistance to drug, and carcinostatic agent |
-
1994
- 1994-12-09 CA CA 2137755 patent/CA2137755C/en not_active Expired - Fee Related
-
1995
- 1995-01-10 GB GB9500442A patent/GB2290235B/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
GB2290235B (en) | 1998-03-25 |
CA2137755C (en) | 2002-07-02 |
GB2290235A (en) | 1995-12-20 |
GB9500442D0 (en) | 1995-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |