CA2125681A1 - 4-amino-3-acyl quinoline derivatives and their use as inhibitors of gastric acid secretion - Google Patents

4-amino-3-acyl quinoline derivatives and their use as inhibitors of gastric acid secretion

Info

Publication number
CA2125681A1
CA2125681A1 CA002125681A CA2125681A CA2125681A1 CA 2125681 A1 CA2125681 A1 CA 2125681A1 CA 002125681 A CA002125681 A CA 002125681A CA 2125681 A CA2125681 A CA 2125681A CA 2125681 A1 CA2125681 A1 CA 2125681A1
Authority
CA
Canada
Prior art keywords
denotes
methylphenylamino
quinolin
ester
butyryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002125681A
Other languages
English (en)
French (fr)
Inventor
Gerhard Gundler
Georg Rainer
Robert John Ife
Colin Andrew Leach
Stefan Postius
Richard Riedel
Hartmann Schaefer
Jorg Senn-Bilfinger
Wolfgang-Alexander Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Intercredit BV
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2125681A1 publication Critical patent/CA2125681A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002125681A 1991-12-12 1992-12-10 4-amino-3-acyl quinoline derivatives and their use as inhibitors of gastric acid secretion Abandoned CA2125681A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9126438.2 1991-12-12
GB919126438A GB9126438D0 (en) 1991-12-12 1991-12-12 New quinoline derivatives

Publications (1)

Publication Number Publication Date
CA2125681A1 true CA2125681A1 (en) 1993-06-24

Family

ID=10706172

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002125681A Abandoned CA2125681A1 (en) 1991-12-12 1992-12-10 4-amino-3-acyl quinoline derivatives and their use as inhibitors of gastric acid secretion

Country Status (8)

Country Link
EP (1) EP0642500A1 (de)
JP (1) JPH07501812A (de)
AU (1) AU665223B2 (de)
CA (1) CA2125681A1 (de)
GB (1) GB9126438D0 (de)
MX (1) MX9207162A (de)
WO (1) WO1993012090A1 (de)
ZA (1) ZA929568B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IS4164A (is) * 1993-06-11 1994-12-12 Ab Astra Efnasambönd sem hindra flæði magasýru
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
GB8804444D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8918265D0 (en) * 1989-08-10 1989-09-20 Smithkline Beckman Intercredit Compounds
MA22401A1 (fr) * 1991-01-29 1992-10-01 Smithkline Beecham Intercredit Procede de preparation de sels de guinoleine

Also Published As

Publication number Publication date
GB9126438D0 (en) 1992-02-12
ZA929568B (en) 1994-06-10
WO1993012090A1 (en) 1993-06-24
MX9207162A (es) 1994-08-31
JPH07501812A (ja) 1995-02-23
EP0642500A1 (de) 1995-03-15
AU665223B2 (en) 1995-12-21
AU3158593A (en) 1993-07-19

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Legal Events

Date Code Title Description
FZDE Dead