CA2119253A1 - Medication Vehicles Made of Solid Lipid Particles (Solid Lipid Nanospheres-SLN) - Google Patents

Medication Vehicles Made of Solid Lipid Particles (Solid Lipid Nanospheres-SLN)

Info

Publication number
CA2119253A1
CA2119253A1 CA 2119253 CA2119253A CA2119253A1 CA 2119253 A1 CA2119253 A1 CA 2119253A1 CA 2119253 CA2119253 CA 2119253 CA 2119253 A CA2119253 A CA 2119253A CA 2119253 A1 CA2119253 A1 CA 2119253A1
Authority
CA
Canada
Prior art keywords
solid lipid
sln
drug carrier
nanospheres
solid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2119253
Other languages
French (fr)
Other versions
CA2119253C (en
Inventor
Stefan Lucks
Rainer Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jagotec AG
Original Assignee
Stefan Lucks
Rainer Muller
Medac Gesellschaft Fur Klinische Spezialpraparate Mbh
Skyepharma Plc
Jagotec Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6441225&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2119253(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Stefan Lucks, Rainer Muller, Medac Gesellschaft Fur Klinische Spezialpraparate Mbh, Skyepharma Plc, Jagotec Ag filed Critical Stefan Lucks
Publication of CA2119253A1 publication Critical patent/CA2119253A1/en
Application granted granted Critical
Publication of CA2119253C publication Critical patent/CA2119253C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides

Abstract

The invention relates to a drug carrier which comprises particles of lipid or lipid-like (lipoid) material or mixtures thereof which have a diameter of 10 nm to 10 µm and which are solid at room temperature. On account of its solid core, the drug carrier allows a controllable liberation of active substances over a longer period of time and the incorporation of hydrophilous medicinal agents into the solid core. Furthermore, the drug carrier makes a relatively quick degrading possible at which no toxic by-products are produced.
CA002119253A 1991-09-18 1992-09-16 Medication vehicles made of solid lipid particles (solid lipid nanospheres-sln) Expired - Lifetime CA2119253C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4131562A DE4131562A1 (en) 1991-09-18 1991-09-18 SOLID LIPID PARTICLE SOLID LIPID NANOSPHERES (SLN)
DEP4131562.6 1991-09-18

Publications (2)

Publication Number Publication Date
CA2119253A1 true CA2119253A1 (en) 1993-04-01
CA2119253C CA2119253C (en) 1998-11-03

Family

ID=6441225

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002119253A Expired - Lifetime CA2119253C (en) 1991-09-18 1992-09-16 Medication vehicles made of solid lipid particles (solid lipid nanospheres-sln)

Country Status (13)

Country Link
EP (1) EP0605497B2 (en)
JP (1) JP2683575B2 (en)
KR (1) KR0141504B1 (en)
AT (1) ATE135567T1 (en)
AU (1) AU672177B2 (en)
CA (1) CA2119253C (en)
CZ (1) CZ289253B6 (en)
DE (2) DE4131562A1 (en)
DK (1) DK0605497T4 (en)
ES (1) ES2085035T5 (en)
GR (2) GR3019750T3 (en)
HU (1) HU227680B1 (en)
WO (1) WO1993005768A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8029823B2 (en) 1999-06-14 2011-10-04 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
US8445024B2 (en) 2005-10-25 2013-05-21 Evonik Degussa Gmbh Preparations containing hyperbranched polymers
US8663692B1 (en) 1999-05-07 2014-03-04 Pharmasol Gmbh Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
US8911788B2 (en) 2003-03-24 2014-12-16 Capsugel France SAS Galenical system for active transport, method for preparation and use
US10660858B2 (en) 2011-09-07 2020-05-26 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition

Families Citing this family (45)

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DE4308282C2 (en) * 1993-03-16 1994-12-22 Beiersdorf Ag Galenic matrices preferably in the form of microspheres
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
DE4336407A1 (en) * 1993-10-21 1995-04-27 Rotring Int Gmbh Waterproof cosmetics
WO1996034109A1 (en) * 1995-04-25 1996-10-31 Vical Incorporated Single-vial formulations of dna/lipid complexes
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
EP1010435B1 (en) * 1997-09-05 2010-11-03 Maruho K.K. Nanocapsule preparations for treating intraarticular diseases
IT1296914B1 (en) 1997-12-01 1999-08-03 Maria Rosa Gasco PHARMACEUTICAL COMPOSITION INCLUDING MICROPARTICLES SUITABLE FOR TRANSMUCOSAL PASSAGE AND OVERCOMING THE BARRIER
ATE259220T1 (en) 1998-05-29 2004-02-15 Skyepharma Canada Inc MICROPARTICLES PROTECTED AGAINST HEAT AND METHOD FOR THE TERMINAL STEAM STERILIZATION OF SAME
SK288117B6 (en) 1998-11-20 2013-09-03 Skyepharma Canada Inc. Rapidly dispersing solid dry therapeutic dosage form
DE19856432A1 (en) 1998-12-08 2000-06-15 Basf Ag Nanoparticulate core-shell systems and their use in pharmaceutical and cosmetic preparations
AU6433400A (en) * 1999-07-13 2001-01-30 Pharmasol Gmbh Uv radiation reflecting or absorbing agents, protecting against harmful uv radiation and reinforcing the natural skin barrier
WO2002026272A1 (en) * 2000-09-29 2002-04-04 Salvona L.L.C. Multi component controlled release system for sanitary paper products
EP1269994A3 (en) 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
KR20010090030A (en) * 2001-08-09 2001-10-18 임정옥 Manufacturing and synergic effect of topical anesthetic formula consisted of mixed local anesthetics
KR100452165B1 (en) * 2002-01-29 2004-10-08 주식회사 태평양 Oil-in-Water type nano-emulsion comprising a lecithin and an anionic surfactant for cosmetic, dermatological, and pharmaceutical vehicles containing thereof
DE10312763A1 (en) 2003-03-21 2004-09-30 IFAC Institut für angewandte Colloidtechnologie GmbH & Co. KG Process for the preparation of an SLN dispersion
CA2524589A1 (en) 2003-05-07 2004-11-18 Ifac Gmbh & Co. Kg Compositions for the targetted release of fragrances and aromas
FR2864900B1 (en) * 2004-01-09 2007-10-12 Oreal AQUEOUS DISPERSION OF NANOCAPSULES WITH OILY HEART
EP1734937A1 (en) * 2004-03-26 2006-12-27 Cell Therapeutics Europe S.R.L. Nanoparticle formulations of platinum compounds
EP1674081A1 (en) 2004-12-23 2006-06-28 KTB Tumorforschungsgesellschaft mbH Preparation of lipid based nano-particles with a dual asymetric centrifuge
JP4533185B2 (en) * 2005-02-24 2010-09-01 花王株式会社 Solid lipid particle formulation
KR20080015077A (en) * 2005-05-05 2008-02-18 사노피-아벤티스 유.에스. 엘엘씨 Stable nanoparticle formulations
ITMI20061274A1 (en) * 2006-06-30 2008-01-01 Consiglio Nazionale Ricerche LIPID NANOPARTICELLAR VECTORS CONTAINING RELIEF AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
US9114077B2 (en) 2006-11-17 2015-08-25 Abbvie Deutschland Gmbh & Co Kg Nanocrystals for use in topical cosmetic formulations and method of production thereof
EP1982698A1 (en) * 2007-04-18 2008-10-22 Evonik Degussa GmbH Preparations for controlled release of natural bioactive materials
EP2108361A1 (en) * 2008-04-09 2009-10-14 ROVI Cosmetics International GmbH Emulgating microparticles made of lipids for stabilising lipophilic agents for cosmetic use
EP2218447B1 (en) 2008-11-04 2017-04-19 PharmaSol GmbH Compositions containing lipid micro- or nanoparticles for the enhancement of the dermal action of solid particles
FR2950253B1 (en) 2009-09-24 2011-09-23 Ethypharm Sa LIPID NANOCAPSULES, PREPARATION METHOD AND USE AS MEDICAMENT
ES2384060B1 (en) 2010-03-24 2013-09-23 Lipotec S.A. LIPID NANOPARTICLES CAPSULES.
GB201021937D0 (en) * 2010-12-24 2011-02-02 Reckitt & Colman Overseas Skin sanitizer compositions comprising alcohol based emulsion
US9352289B2 (en) 2010-12-28 2016-05-31 Conopco, Inc. Method for production of an emulsion
KR20140031227A (en) 2011-03-24 2014-03-12 레오 파마 에이/에스 A composition comprising lipid nanoparticles and a corticosteroid or vitamin d derivative
DE102011018499A1 (en) 2011-04-23 2012-10-25 Emc Microcollections Gmbh Topical nanoparticle vaccine for the immune stimulation of dendritic cells in the skin
DE102011116069A1 (en) 2011-10-18 2013-04-18 Dr. Rimpler Gmbh Lipid nanoparticle dispersion, process for its preparation and its use
ITBO20130376A1 (en) 2013-07-18 2015-01-19 Ferbi Srl METHOD FOR THE PREPARATION OF SOLID LIPID NANOPARTICLES CONTAINING ANTIBODIES IN THE FORM OF A IONIAN COUPLE, THROUGH THE COACERVATION TECHNIQUE OF FATTY ACIDS
WO2016100228A2 (en) * 2014-12-15 2016-06-23 Nanosphere Health Sciences, Llc Methods of treating inflammatory disorders and global inflammation with compositions comprising phospholipid nanoparticle encapsulations of nsaids
AU2015385825A1 (en) 2015-03-10 2017-10-05 Nanosphere Health Sciences, Llc Lipid nanoparticle compositions and methods as carriers of cannabinoids in standardized precision-metered dosage forms
CZ307681B6 (en) 2016-02-29 2019-02-13 Ústav makromolekulární chemie AV ČR, v. v. i. A photoactivatable nanoparticle for photodynamic applications, the method of its preparation, a pharmaceutical composition comprising it and their use
US20210069121A1 (en) 2017-12-12 2021-03-11 Lead Biotherapeutics Ltd Solid lipid nanoparticle for intracellular release of active substances and method for production the same
US11504327B1 (en) 2019-01-21 2022-11-22 Eric Morrison Method of preparing nanoparticles by hot-melt extrusion
IT201900009258A1 (en) 2019-06-17 2020-12-17 R Bio Transfer S R L METHOD FOR THE PREPARATION OF LIPID NANOPARTICLES
IT201900013353A1 (en) 2019-07-30 2021-01-30 Univ Della Calabria Bergamot essential oil delivery system based on nanotechnologies, method of preparation of the system and its uses.
WO2023275648A1 (en) 2021-06-30 2023-01-05 Novocure Gmbh Compositions and methods for using alternating electric fields to disrupt lipid capsules
IT202100023570A1 (en) 2021-09-13 2023-03-13 Bioema S R L S Biotecnologia Energia Mat Ambiente METHOD FOR THE PREPARATION OF LIPID NANOPARTICLES
DE202023100649U1 (en) 2023-02-10 2023-03-22 Cineolux Gmbh Dispersion and preparation for topical use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3421468A1 (en) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim LIPID NANOPELLETS AS A CARRIER SYSTEM FOR MEDICINAL PRODUCTS FOR PERORAL USE
NZ231281A (en) * 1988-11-08 1991-01-29 Takeda Chemical Industries Ltd Sustained release pharmaceutical preparations comprising the active agent dispersed in a solid matrix of a fatty acid ester of a polyglycerol
LU87410A1 (en) * 1988-12-20 1990-07-10 Cird COSMETIC OR PHARMACEUTICAL COMPOSITION CONTAINING POLYMERIC OR FATTY BODY MICROSPHERES CHARGED WITH AT LEAST ONE ACTIVE PRODUCT
FR2651680B1 (en) * 1989-09-14 1991-12-27 Medgenix Group Sa NOVEL PROCESS FOR THE PREPARATION OF LIPID MICROPARTICLES.
FR2657257B1 (en) * 1990-01-19 1994-09-02 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF DRUGS IN THE FORM OF PEARLS.

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8663692B1 (en) 1999-05-07 2014-03-04 Pharmasol Gmbh Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
US9532954B2 (en) 1999-06-14 2017-01-03 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical compositions
USRE43799E1 (en) 1999-06-14 2012-11-13 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
US8293273B2 (en) 1999-06-14 2012-10-23 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
US8784888B2 (en) 1999-06-14 2014-07-22 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
US9320716B2 (en) 1999-06-14 2016-04-26 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical compositions
US8029823B2 (en) 1999-06-14 2011-10-04 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
US9592203B2 (en) 1999-06-14 2017-03-14 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
US9737489B2 (en) 1999-06-14 2017-08-22 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
US8911788B2 (en) 2003-03-24 2014-12-16 Capsugel France SAS Galenical system for active transport, method for preparation and use
US8445024B2 (en) 2005-10-25 2013-05-21 Evonik Degussa Gmbh Preparations containing hyperbranched polymers
US10660858B2 (en) 2011-09-07 2020-05-26 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition

Also Published As

Publication number Publication date
JPH06510772A (en) 1994-12-01
GR3030291T3 (en) 1999-09-30
AU672177B2 (en) 1996-09-26
ATE135567T1 (en) 1996-04-15
EP0605497B2 (en) 1999-04-14
ES2085035T3 (en) 1996-05-16
CZ59694A3 (en) 1994-07-13
DE4131562A1 (en) 1993-03-25
WO1993005768A1 (en) 1993-04-01
CA2119253C (en) 1998-11-03
KR0141504B1 (en) 1998-06-01
ES2085035T5 (en) 1999-06-16
HU227680B1 (en) 2011-11-28
DK0605497T4 (en) 1999-10-25
DE59205783D1 (en) 1996-04-25
AU2561592A (en) 1993-04-27
EP0605497A1 (en) 1994-07-13
CZ289253B6 (en) 2001-12-12
HUT75165A (en) 1997-04-28
JP2683575B2 (en) 1997-12-03
GR3019750T3 (en) 1996-07-31
DK0605497T3 (en) 1996-08-05
HU9400779D0 (en) 1994-06-28
EP0605497B1 (en) 1996-03-20

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Legal Events

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EEER Examination request
MKEX Expiry