CA2112818A1 - Mono et bis-alkylamine-anthracyclines - Google Patents

Mono et bis-alkylamine-anthracyclines

Info

Publication number: CA2112818A1
Authority: CA; Canada
Prior art keywords: group; hydrogen; formula; anthracyclines; mono
Prior art date: 1991-07-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA002112818A

Other languages

English (en)

Other versions

CA2112818C (fr

Inventor

Alberto Bargiotti

Michele Caruso

Daniela Faiardi

Antonino Suarato

Nicola Mongelli

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Italia SRL

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-05

Filing date

1992-07-03

Publication date

1993-01-21

1992-07-03 Application filed by Individual filed Critical Individual

1993-01-21 Publication of CA2112818A1 publication Critical patent/CA2112818A1/fr

2003-02-04 Application granted granted Critical

2003-02-04 Publication of CA2112818C publication Critical patent/CA2112818C/fr

2012-07-03 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

229940045799 anthracyclines and related substance Drugs 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
229910052736 halogen Chemical group 0.000 abstract 2
150000002367 halogens Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229930182470 glycoside Natural products 0.000 abstract 1
150000002338 glycosides Chemical class 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
-1 nitro, amino, methoxy Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA002112818A 1991-07-05 1992-07-03 Mono et bis-alkylamine-anthracyclines Expired - Fee Related CA2112818C (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB919114549A GB9114549D0 (en)	1991-07-05	1991-07-05	Mono and bis alkylamino-anthracyclines
GB9114549.0		1991-07-05
PCT/EP1992/001504 WO1993001201A1 (fr)	1991-07-05	1992-07-03	Anthracyclines monoalkylamino et bisalkylamino

Publications (2)

Publication Number	Publication Date
CA2112818A1 true CA2112818A1 (fr)	1993-01-21
CA2112818C CA2112818C (fr)	2003-02-04

Family

ID=10697877

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002112818A Expired - Fee Related CA2112818C (fr)	1991-07-05	1992-07-03	Mono et bis-alkylamine-anthracyclines

Country Status (24)

Country	Link
US (1)	US5496808A (fr)
EP (1)	EP0521458B1 (fr)
JP (1)	JP3153552B2 (fr)
KR (1)	KR100235365B1 (fr)
CN (1)	CN1031878C (fr)
AT (1)	ATE134376T1 (fr)
AU (1)	AU661012B2 (fr)
CA (1)	CA2112818C (fr)
CZ (1)	CZ2494A3 (fr)
DE (1)	DE69208400T2 (fr)
FI (1)	FI106204B (fr)
GB (1)	GB9114549D0 (fr)
GR (1)	GR3019429T3 (fr)
HK (1)	HK1006460A1 (fr)
HU (1)	HU218913B (fr)
IE (1)	IE76921B1 (fr)
IL (1)	IL102409A (fr)
MX (1)	MX9203928A (fr)
NO (1)	NO300099B1 (fr)
NZ (1)	NZ243450A (fr)
RU (1)	RU2118328C1 (fr)
TW (1)	TW201753B (fr)
WO (1)	WO1993001201A1 (fr)
ZA (1)	ZA924971B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9325420D0 (en) *	1993-12-13	1994-02-16	Erba Carlo Spa	4'-o-sulfonyl-anthracycline derivatives
CA2199734A1 (fr) *	1994-09-12	1996-03-21	Fraser Aird	Facteur inhibiteur de liberation de la corticotropine et procedes d'utilisation
EP0768317B1 (fr) *	1995-10-16	1999-01-27	Kyowa Hakko Kogyo Co., Ltd.	Composés UCK14
DE19548474A1 (de) *	1995-12-22	1997-06-26	Wacker Chemie Gmbh	Aliphatisch ungesättigte Reste aufweisende Organopolysiloxane, deren Herstellung und deren Verwendung in vernetzbaren Massen
GB9613433D0 (en) *	1996-06-26	1996-08-28	Pharmacia Spa	Fluoro labelled anthracyclinone and anthracycline derivatives
US6086876A (en) *	1997-02-07	2000-07-11	The Wistar Insitute	Methods and compositions for the inhibition of interleukin-12 production
GB9806324D0 (en) *	1998-03-24	1998-05-20	Pharmacia & Upjohn Spa	Antitumour synergetic composition
GB9904386D0 (en) *	1999-02-25	1999-04-21	Pharmacia & Upjohn Spa	Antitumour synergistic composition
GB9904387D0 (en) *	1999-02-25	1999-04-21	Pharmacia & Upjohn Spa	Antitumour synergistic composition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU570439B2 (en) *	1983-03-28	1988-03-17	Compression Labs, Inc.	A combined intraframe and interframe transform coding system
US4591637A (en) *	1985-01-17	1986-05-27	Sri International	Open chain-morpholino adriamycins
FR2591599B1 (fr) *	1985-12-17	1988-08-05	Hoechst Lab	Nouvelles anthracyclines et medicaments les contenant
DE3842836A1 (de) *	1988-12-20	1990-06-21	Behringwerke Ag	Rhodomycine mit einer modifizierten kohlenhydrat-einheit

1991
- 1991-07-05 GB GB919114549A patent/GB9114549D0/en active Pending
1992
- 1992-06-26 US US07/904,650 patent/US5496808A/en not_active Expired - Fee Related
- 1992-06-30 EP EP92111054A patent/EP0521458B1/fr not_active Expired - Lifetime
- 1992-06-30 AT AT92111054T patent/ATE134376T1/de active
- 1992-06-30 DE DE69208400T patent/DE69208400T2/de not_active Expired - Fee Related
- 1992-07-03 CA CA002112818A patent/CA2112818C/fr not_active Expired - Fee Related
- 1992-07-03 ZA ZA924971A patent/ZA924971B/xx unknown
- 1992-07-03 MX MX9203928A patent/MX9203928A/es not_active IP Right Cessation
- 1992-07-03 WO PCT/EP1992/001504 patent/WO1993001201A1/fr not_active Application Discontinuation
- 1992-07-03 IE IE922177A patent/IE76921B1/en not_active IP Right Cessation
- 1992-07-03 KR KR1019940700015A patent/KR100235365B1/ko not_active IP Right Cessation
- 1992-07-03 JP JP50195893A patent/JP3153552B2/ja not_active Expired - Fee Related
- 1992-07-03 CZ CZ9424A patent/CZ2494A3/cs unknown
- 1992-07-03 RU RU94021658A patent/RU2118328C1/ru active
- 1992-07-03 HU HU9400022A patent/HU218913B/hu not_active IP Right Cessation
- 1992-07-03 AU AU22294/92A patent/AU661012B2/en not_active Ceased
- 1992-07-03 IL IL10240992A patent/IL102409A/en not_active IP Right Cessation
- 1992-07-04 CN CN92108867A patent/CN1031878C/zh not_active Expired - Fee Related
- 1992-07-04 TW TW081105323A patent/TW201753B/zh active
- 1992-07-06 NZ NZ243450A patent/NZ243450A/en unknown
1994
- 1994-01-03 FI FI940011A patent/FI106204B/fi active
- 1994-01-04 NO NO940026A patent/NO300099B1/no not_active IP Right Cessation
1996
- 1996-03-27 GR GR960400814T patent/GR3019429T3/el unknown
1998
- 1998-06-19 HK HK98105711A patent/HK1006460A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
GR3019429T3 (en)	1996-06-30
IL102409A0 (en)	1993-01-14
CA2112818C (fr)	2003-02-04
TW201753B (fr)	1993-03-11
IE922177A1 (en)	1993-01-13
US5496808A (en)	1996-03-05
NO940026L (no)	1994-02-16
NZ243450A (en)	1993-11-25
HU218913B (hu)	2000-12-28
FI106204B (fi)	2000-12-15
FI940011A0 (fi)	1994-01-03
WO1993001201A1 (fr)	1993-01-21
FI940011A (fi)	1994-01-03
CN1031878C (zh)	1996-05-29
EP0521458B1 (fr)	1996-02-21
RU2118328C1 (ru)	1998-08-27
KR100235365B1 (ko)	1999-12-15
ZA924971B (en)	1993-03-31
HU9400022D0 (en)	1994-05-30
DE69208400D1 (de)	1996-03-28
JP3153552B2 (ja)	2001-04-09
CZ2494A3 (en)	1994-07-13
DE69208400T2 (de)	1996-06-27
EP0521458A1 (fr)	1993-01-07
NO300099B1 (no)	1997-04-07
JPH06508841A (ja)	1994-10-06
IL102409A (en)	1995-12-08
ATE134376T1 (de)	1996-03-15
HUT70480A (en)	1995-10-30
HK1006460A1 (en)	1999-02-26
NO940026D0 (no)	1994-01-04
AU661012B2 (en)	1995-07-13
GB9114549D0 (en)	1991-08-21
AU2229492A (en)	1993-02-11
CN1069981A (zh)	1993-03-17
MX9203928A (es)	1993-04-01
IE76921B1 (en)	1997-11-05

Legal Events

Date	Code	Title	Description
1999-05-27	EEER	Examination request
2007-07-03	MKLA	Lapsed

Publication	Publication Date	Title
AU4925199A (en)	2000-03-21	Quinolin-2-one derivatives useful as anticancer agents
EP0163599A3 (en)	1987-02-25	Pyrimidopyrimidine derivatives, processes for producing them, pharmaceutical compositions containing them and their use as anti-allergic agents
CA2341690A1 (fr)	2000-03-09	Derives de quinolin-2-one a substitution alcynyle, utiles en tant qu'agents anticancereux
CA2000830A1 (fr)	1990-04-20	Halogenures de l'acide 0-(3-amino-2-2hydroxypropyl)-hydroxymique et procede de preparation
NZ320580A (en)	1998-12-23	Tricyclic compounds, preparation and pharmaceutical compositions thereof
TW370527B (en)	1999-09-21	Crystalline anhydrous mycophenolate mofetil, pharmaceutical composition, intravenous formulation and kit containing the same, and preparation thereof
CA2112818A1 (fr)	1993-01-21	Mono et bis-alkylamine-anthracyclines
IL114833A0 (en)	1995-12-08	Anthracyclinone derivatives their preparation and pharmaceutical compositions containing them
EP0786252A4 (fr)	1998-01-07	Agent antitumoral
IL111725A0 (en)	1995-01-24	3'-aziridino-anthracycline derivatives, their preparation and pharmaceutical compositions containing them
RU94021658A (ru)	1995-09-10	Моно и бисалкиламино-антрациклины, способ получения, фармацевтическая композиция
DE69029781D1 (de)	1997-03-06	Anthracyclinglycosid-Derivate und Verfahren zu ihrer Herstellung
AU5930194A (en)	1994-10-13	Thioxanthenone antitumor agents
CA2108817A1 (fr)	1994-04-23	Arylidene-1-azacycloalcanes et arylalkyl-1-azacycloalcanes, leurs sels, medicaments qui contiennent de ces composes et leur utilisation, et procedes pour leur obtention
ZA846783B (en)	1985-04-24	Nitrosourea derivatives,process for their preparation and pharmaceuticals containing them
ATE44281T1 (de)	1989-07-15	Benzoselenino(4,3,2-cd>indazolverbindungen, diese enthaltende zubereitungen und verfahren zu ihrer herstellung.
ES8305703A1 (es)	1983-04-16	Un derivado de 2-benzoilamino-bencilamina.
IL114646A (en)	2000-02-29	Pharmaceutical compositions containing phenylurea derivatives for inhibiting leukotriene biosynthesis
WO1995016693A3 (fr)	1995-07-20	Derives de 4'-o-sulfonyl-anthracycline
GR852126B (fr)	1986-01-03
GB2281564B (en)	1997-10-29	Substituted cis-dihydroxycyclohexadienes and methods for their preparation