CA2108113A1 - Sequence d'adn codant pour des enzymes de la synthese de l'acide clavulanique - Google Patents

Sequence d'adn codant pour des enzymes de la synthese de l'acide clavulanique

Info

Publication number
CA2108113A1
CA2108113A1 CA 2108113 CA2108113A CA2108113A1 CA 2108113 A1 CA2108113 A1 CA 2108113A1 CA 2108113 CA2108113 CA 2108113 CA 2108113 A CA2108113 A CA 2108113A CA 2108113 A1 CA2108113 A1 CA 2108113A1
Authority
CA
Canada
Prior art keywords
clavulanic acid
sequence encoding
dna sequence
acid biosynthesis
encoding enzymes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2108113
Other languages
English (en)
Other versions
CA2108113C (fr
Inventor
Susan E. Jensen
Kwamena A. Aidoo
Ashish S. Paradkar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Alberta
Original Assignee
University of Alberta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Alberta filed Critical University of Alberta
Priority to CA 2108113 priority Critical patent/CA2108113C/fr
Publication of CA2108113A1 publication Critical patent/CA2108113A1/fr
Application granted granted Critical
Publication of CA2108113C publication Critical patent/CA2108113C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA 2108113 1993-10-08 1993-10-08 Sequence d'adn codant pour des enzymes de la synthese de l'acide clavulanique Expired - Fee Related CA2108113C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA 2108113 CA2108113C (fr) 1993-10-08 1993-10-08 Sequence d'adn codant pour des enzymes de la synthese de l'acide clavulanique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 2108113 CA2108113C (fr) 1993-10-08 1993-10-08 Sequence d'adn codant pour des enzymes de la synthese de l'acide clavulanique

Publications (2)

Publication Number Publication Date
CA2108113A1 true CA2108113A1 (fr) 1995-04-09
CA2108113C CA2108113C (fr) 2006-12-05

Family

ID=4152430

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2108113 Expired - Fee Related CA2108113C (fr) 1993-10-08 1993-10-08 Sequence d'adn codant pour des enzymes de la synthese de l'acide clavulanique

Country Status (1)

Country Link
CA (1) CA2108113C (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033896A2 (fr) * 1997-02-04 1998-08-06 Smithkline Beecham Plc Nouvelles compositions
ES2131001A1 (es) * 1997-06-16 1999-07-01 Antibioticos Sau Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus.
WO2000003581A1 (fr) * 1998-07-17 2000-01-27 Smithkline Beecham P.L.C. Procede pour preparer des derives de clavame au moyen de polypeptides presentant une activite de beta-lactame synthetase
EP1218486A1 (fr) * 1999-09-16 2002-07-03 The Johns-Hopkins University Production amelioree d'acide clavulanique
WO2003040372A2 (fr) * 2001-11-07 2003-05-15 Smithkline Beecham P.L.C. Nouvelles molecules
WO2003052113A1 (fr) * 2001-12-19 2003-06-26 Isis Innovation Limited Procede de cyclisation pour la preparation de composes de c-2 beta-lactam substitue
US7622302B1 (en) 2003-04-15 2009-11-24 Glaxo Group Limited Process for improving the manufacture of clavams e.g. clavulanic acid

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1405913A2 (fr) * 1997-02-04 2004-04-07 SmithKline Beecham plc Procédé ameliorée pour la production de 5R clavams
WO1998033896A3 (fr) * 1997-02-04 1998-11-19 Smithkline Beecham Plc Nouvelles compositions
WO1998033896A2 (fr) * 1997-02-04 1998-08-06 Smithkline Beecham Plc Nouvelles compositions
US7344869B2 (en) 1997-02-04 2008-03-18 Smithkline Beecham P.L.C. Isolated DNA comprising one or more genes specific for 5S clavam biosynthesis, vectors comprising such DNA and Streptomyces hosts capable of improved clavulanic acid production
US6936458B1 (en) 1997-02-04 2005-08-30 Smithkline Beecham P.L.C. Isolated DNA comprising one or more genes specific for 5S clavam biosynthesis, vectors comprising such DNA and streptomyces hosts capable of improved clavulanic acid production
EP1405913A3 (fr) * 1997-02-04 2004-08-04 SmithKline Beecham plc Procédé ameliorée pour la production de 5R clavams
ES2131001A1 (es) * 1997-06-16 1999-07-01 Antibioticos Sau Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus.
WO2000003581A1 (fr) * 1998-07-17 2000-01-27 Smithkline Beecham P.L.C. Procede pour preparer des derives de clavame au moyen de polypeptides presentant une activite de beta-lactame synthetase
US6905849B1 (en) 1998-07-17 2005-06-14 Smithkline Beecham Plc Process for preparing clavam derivatives by using polypeptides having β-lactam synthetase activity
EP1218486A4 (fr) * 1999-09-16 2002-11-04 Univ Johns Hopkins Production amelioree d'acide clavulanique
EP1218486A1 (fr) * 1999-09-16 2002-07-03 The Johns-Hopkins University Production amelioree d'acide clavulanique
WO2003040372A3 (fr) * 2001-11-07 2003-11-13 Smithkline Beecham Plc Nouvelles molecules
WO2003040372A2 (fr) * 2001-11-07 2003-05-15 Smithkline Beecham P.L.C. Nouvelles molecules
WO2003052113A1 (fr) * 2001-12-19 2003-06-26 Isis Innovation Limited Procede de cyclisation pour la preparation de composes de c-2 beta-lactam substitue
US7622302B1 (en) 2003-04-15 2009-11-24 Glaxo Group Limited Process for improving the manufacture of clavams e.g. clavulanic acid

Also Published As

Publication number Publication date
CA2108113C (fr) 2006-12-05

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20131009