CA2108113A1 - Sequence d'adn codant pour des enzymes de la synthese de l'acide clavulanique - Google Patents
Sequence d'adn codant pour des enzymes de la synthese de l'acide clavulaniqueInfo
- Publication number
- CA2108113A1 CA2108113A1 CA 2108113 CA2108113A CA2108113A1 CA 2108113 A1 CA2108113 A1 CA 2108113A1 CA 2108113 CA2108113 CA 2108113 CA 2108113 A CA2108113 A CA 2108113A CA 2108113 A1 CA2108113 A1 CA 2108113A1
- Authority
- CA
- Canada
- Prior art keywords
- clavulanic acid
- sequence encoding
- dna sequence
- acid biosynthesis
- encoding enzymes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2108113 CA2108113C (fr) | 1993-10-08 | 1993-10-08 | Sequence d'adn codant pour des enzymes de la synthese de l'acide clavulanique |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2108113 CA2108113C (fr) | 1993-10-08 | 1993-10-08 | Sequence d'adn codant pour des enzymes de la synthese de l'acide clavulanique |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2108113A1 true CA2108113A1 (fr) | 1995-04-09 |
CA2108113C CA2108113C (fr) | 2006-12-05 |
Family
ID=4152430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2108113 Expired - Fee Related CA2108113C (fr) | 1993-10-08 | 1993-10-08 | Sequence d'adn codant pour des enzymes de la synthese de l'acide clavulanique |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2108113C (fr) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998033896A2 (fr) * | 1997-02-04 | 1998-08-06 | Smithkline Beecham Plc | Nouvelles compositions |
ES2131001A1 (es) * | 1997-06-16 | 1999-07-01 | Antibioticos Sau | Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus. |
WO2000003581A1 (fr) * | 1998-07-17 | 2000-01-27 | Smithkline Beecham P.L.C. | Procede pour preparer des derives de clavame au moyen de polypeptides presentant une activite de beta-lactame synthetase |
EP1218486A1 (fr) * | 1999-09-16 | 2002-07-03 | The Johns-Hopkins University | Production amelioree d'acide clavulanique |
WO2003040372A2 (fr) * | 2001-11-07 | 2003-05-15 | Smithkline Beecham P.L.C. | Nouvelles molecules |
WO2003052113A1 (fr) * | 2001-12-19 | 2003-06-26 | Isis Innovation Limited | Procede de cyclisation pour la preparation de composes de c-2 beta-lactam substitue |
US7622302B1 (en) | 2003-04-15 | 2009-11-24 | Glaxo Group Limited | Process for improving the manufacture of clavams e.g. clavulanic acid |
-
1993
- 1993-10-08 CA CA 2108113 patent/CA2108113C/fr not_active Expired - Fee Related
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1405913A2 (fr) * | 1997-02-04 | 2004-04-07 | SmithKline Beecham plc | Procédé ameliorée pour la production de 5R clavams |
WO1998033896A3 (fr) * | 1997-02-04 | 1998-11-19 | Smithkline Beecham Plc | Nouvelles compositions |
WO1998033896A2 (fr) * | 1997-02-04 | 1998-08-06 | Smithkline Beecham Plc | Nouvelles compositions |
US7344869B2 (en) | 1997-02-04 | 2008-03-18 | Smithkline Beecham P.L.C. | Isolated DNA comprising one or more genes specific for 5S clavam biosynthesis, vectors comprising such DNA and Streptomyces hosts capable of improved clavulanic acid production |
US6936458B1 (en) | 1997-02-04 | 2005-08-30 | Smithkline Beecham P.L.C. | Isolated DNA comprising one or more genes specific for 5S clavam biosynthesis, vectors comprising such DNA and streptomyces hosts capable of improved clavulanic acid production |
EP1405913A3 (fr) * | 1997-02-04 | 2004-08-04 | SmithKline Beecham plc | Procédé ameliorée pour la production de 5R clavams |
ES2131001A1 (es) * | 1997-06-16 | 1999-07-01 | Antibioticos Sau | Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus. |
WO2000003581A1 (fr) * | 1998-07-17 | 2000-01-27 | Smithkline Beecham P.L.C. | Procede pour preparer des derives de clavame au moyen de polypeptides presentant une activite de beta-lactame synthetase |
US6905849B1 (en) | 1998-07-17 | 2005-06-14 | Smithkline Beecham Plc | Process for preparing clavam derivatives by using polypeptides having β-lactam synthetase activity |
EP1218486A4 (fr) * | 1999-09-16 | 2002-11-04 | Univ Johns Hopkins | Production amelioree d'acide clavulanique |
EP1218486A1 (fr) * | 1999-09-16 | 2002-07-03 | The Johns-Hopkins University | Production amelioree d'acide clavulanique |
WO2003040372A3 (fr) * | 2001-11-07 | 2003-11-13 | Smithkline Beecham Plc | Nouvelles molecules |
WO2003040372A2 (fr) * | 2001-11-07 | 2003-05-15 | Smithkline Beecham P.L.C. | Nouvelles molecules |
WO2003052113A1 (fr) * | 2001-12-19 | 2003-06-26 | Isis Innovation Limited | Procede de cyclisation pour la preparation de composes de c-2 beta-lactam substitue |
US7622302B1 (en) | 2003-04-15 | 2009-11-24 | Glaxo Group Limited | Process for improving the manufacture of clavams e.g. clavulanic acid |
Also Published As
Publication number | Publication date |
---|---|
CA2108113C (fr) | 2006-12-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20131009 |