CA2107329A1 - Anti-Human Immunodeficiency Virus Recombinant Antibodies - Google Patents

Anti-Human Immunodeficiency Virus Recombinant Antibodies

Info

Publication number
CA2107329A1
CA2107329A1 CA2107329A CA2107329A CA2107329A1 CA 2107329 A1 CA2107329 A1 CA 2107329A1 CA 2107329 A CA2107329 A CA 2107329A CA 2107329 A CA2107329 A CA 2107329A CA 2107329 A1 CA2107329 A1 CA 2107329A1
Authority
CA
Canada
Prior art keywords
immunodeficiency virus
human immunodeficiency
recombinant antibodies
virus recombinant
combining site
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2107329A
Other languages
French (fr)
Other versions
CA2107329C (en
Inventor
Bona Constantin
Zaghouani Habib
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icahn School of Medicine at Mount Sinai
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2107329A1 publication Critical patent/CA2107329A1/en
Application granted granted Critical
Publication of CA2107329C publication Critical patent/CA2107329C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Abstract

This invention provides hybrid antibodies which comprise a base portion which corresponds to the constant portion of human immunoglobulin G, a combining site selected for specificity to the particular target antigen, and a combining site which binds to and activates human CTL.
CA002107329A 1991-04-18 1992-04-10 Anti-human immunodeficiency virus recombinant antibodies Expired - Fee Related CA2107329C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68737691A 1991-04-18 1991-04-18
US07/687,376 1991-04-18
PCT/US1992/002975 WO1992018540A1 (en) 1991-04-18 1992-04-10 Anti-human immunodeficiency virus recombinant antibodies

Publications (2)

Publication Number Publication Date
CA2107329A1 true CA2107329A1 (en) 1992-10-19
CA2107329C CA2107329C (en) 1999-04-27

Family

ID=24760226

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002107329A Expired - Fee Related CA2107329C (en) 1991-04-18 1992-04-10 Anti-human immunodeficiency virus recombinant antibodies

Country Status (6)

Country Link
EP (1) EP0580758A4 (en)
JP (1) JPH06506947A (en)
AU (1) AU672580B2 (en)
CA (1) CA2107329C (en)
IL (1) IL101602A (en)
WO (1) WO1992018540A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2047244C (en) * 1989-02-24 2002-09-17 Zanetti Maurizio Genetically engineered immunoglobulins
US5969109A (en) * 1990-02-28 1999-10-19 Bona; Constantin Chimeric antibodies comprising antigen binding sites and B and T cell epitopes
GB0102145D0 (en) * 2001-01-26 2001-03-14 Scancell Ltd Substances

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1338518C (en) * 1987-09-23 1996-08-13 Joyce M. Zarling Antibody heteroconjugates for the killing of hiv-infected cells
ES2131107T3 (en) * 1992-03-17 1999-07-16 Novartis Ag ANTIBODIES OBTAINED THROUGH GENETIC ENGINEERING.
DE69311764T2 (en) * 1992-05-14 1998-02-05 Polymun Scient Immunbio Forsch Peptides that induce antibodies that neutralize genetically divergent HIV-1 isolations

Also Published As

Publication number Publication date
AU672580B2 (en) 1996-10-10
EP0580758A1 (en) 1994-02-02
CA2107329C (en) 1999-04-27
AU1891992A (en) 1992-11-17
IL101602A (en) 1996-10-31
WO1992018540A1 (en) 1992-10-29
JPH06506947A (en) 1994-08-04
IL101602A0 (en) 1992-12-30
EP0580758A4 (en) 1995-04-05

Similar Documents

Publication Publication Date Title
CA2149120A1 (en) Monoclonal antibody which specifically binds to tumor vascular endothelium and uses thereof
IL83113A (en) Bifunctional antibodies having antigen specificity for fc receptor and for an epitope of a target cell
WO1994029451A3 (en) Humanised antibodies
CA2025597A1 (en) Vaccine against lyme disease
CA2118010A1 (en) Antibodies specific for carcinoma-associated antigens
TNSN93012A1 (en) DESIGN, CLONING AND EXPRESSION OF HUMANIZED MONOCLONAL ANTIBODIES AGAINST HUMAN INTERLEUKIN-5
WO1994004691A3 (en) Dimer and multimer forms of single chain polypeptides
AU4230493A (en) Diphtheria toxin receptor-binding region
EP1266965A3 (en) Recombinant antibodies for human therapy
WO1999003987A3 (en) Syncytial respiratory virus epitopes and antibodies comprising them, useful in diagnosis and therapy
CA2109815A1 (en) Antibody preparation
HK1115607A1 (en) Human cytokine receptor
AU676859B2 (en) Synthetic peptides, antibodies against them and their use
AU628948B2 (en) Monoclonal antibodies (mabs) against tumor-associated antigens, the preparation and use thereof
EP1350799A3 (en) Inhibitory Immunoglobulin Polypeptides to Human PDGF Beta Receptor
CA2091263A1 (en) Peptides for use in vaccination and induction of neutralizing antibodies against human immunodeficiency virus
DE3650032D1 (en) ANTICYTOMEGALOVIRAL HUMAN MONOCLONAL ANTIBODIES AND THEIR PRODUCTION.
AU7203194A (en) Bispecific human monoclonal antibodies specific for human immunodeficiency virus
AU1125192A (en) Fusion proteins for prodrug activation, the preparation and use thereof
CA2107329A1 (en) Anti-Human Immunodeficiency Virus Recombinant Antibodies
AU2032988A (en) A genus-specific listeria antigen identified by monoclonal antibodies
ATE211148T1 (en) HCMV-SPECIFIC PEPTIDES AND THEIR USE
AU1423892A (en) Monoclonal antibodies directed towards mycobacterial antigens
CA2070182A1 (en) Chimeric immunoglobulin for cd4 receptors
AU4959193A (en) High affinity, strongly neutralizing monoclonal antibodies against the CD-4 binding site of GP120 of human immunodeficiency virus

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed