CA2091918A1 - L-ascorbic acid production in microorganisms - Google Patents

L-ascorbic acid production in microorganisms

Info

Publication number
CA2091918A1
CA2091918A1 CA2091918A CA2091918A CA2091918A1 CA 2091918 A1 CA2091918 A1 CA 2091918A1 CA 2091918 A CA2091918 A CA 2091918A CA 2091918 A CA2091918 A CA 2091918A CA 2091918 A1 CA2091918 A1 CA 2091918A1
Authority
CA
Canada
Prior art keywords
ascorbic acid
microorganisms
acid production
carbon source
genus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2091918A
Other languages
French (fr)
Other versions
CA2091918C (en
Inventor
Ronald J. Huss
Jeffrey A. Running
Thomas J. Skatrud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DCV Inc
Original Assignee
BIO-TECHNICAL RESOURCES LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIO-TECHNICAL RESOURCES LP filed Critical BIO-TECHNICAL RESOURCES LP
Publication of CA2091918A1 publication Critical patent/CA2091918A1/en
Application granted granted Critical
Publication of CA2091918C publication Critical patent/CA2091918C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C12N1/125—Unicellular algae isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/89—Algae ; Processes using algae

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Improved heterotrophic biosynthetic production of ascorbic acid is obtained using ascorbic acid-producing microalgae in particular of the genus Chlorella and the genus Prototheca, as the microorganism source and growing, the culture undera controlled pattern of carbon source supply. Greatly improved ratios of ascorbic acid to total carbon source supplied as well as enhanced concentrations of ascorbic acid in the fermentor are obtained. C. pyrenoidosa UV 101-158 was deposited at the A.T.C.C. on June 27, 1985 and given Accession No. 53170.
CA002091918A 1992-03-18 1993-03-18 L-ascorbic acid production in microorganisms Expired - Fee Related CA2091918C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85337992A 1992-03-18 1992-03-18
US07/853,379 1992-03-18

Publications (2)

Publication Number Publication Date
CA2091918A1 true CA2091918A1 (en) 1993-09-19
CA2091918C CA2091918C (en) 1998-07-28

Family

ID=25315884

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002091918A Expired - Fee Related CA2091918C (en) 1992-03-18 1993-03-18 L-ascorbic acid production in microorganisms

Country Status (5)

Country Link
JP (1) JP2815127B2 (en)
CN (1) CN1083110A (en)
AU (1) AU3921893A (en)
CA (1) CA2091918C (en)
WO (1) WO1993019192A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69520829T2 (en) * 1994-02-10 2001-08-09 Dcv Inc Production of L - ascorbic acid in microorganisms
FR2820973B1 (en) 2001-02-19 2003-05-23 Oreal COMPOSITION COMPRISING VITAMIN C PREPARED DURING APPLICATION, USE OF ENZYMES FOR THE FORMATION OF VITAMIN C FOR TOPICAL USE AND COSMETIC PROCESSING METHOD
CN102171360A (en) * 2008-10-06 2011-08-31 弗·哈夫曼-拉罗切有限公司 Small scale shaker flask cultivation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001059A (en) * 1985-07-01 1991-03-19 Bio-Technical Resources, Inc. L-ascorbic acid production in microorganisms

Also Published As

Publication number Publication date
JP2815127B2 (en) 1998-10-27
CA2091918C (en) 1998-07-28
JPH0646870A (en) 1994-02-22
CN1083110A (en) 1994-03-02
WO1993019192A1 (en) 1993-09-30
AU3921893A (en) 1993-10-21

Similar Documents

Publication Publication Date Title
EP0207763A3 (en) L-ascorbic acid production in microorganisms
HUT74840A (en) Process for producing different substances with use of microorganismus
PL362620A1 (en) Enhanced production of lipids containing polyenoic fatty acids by high density cultures of eukaryotic microbes in fermentors
PH11996054562B1 (en) Docosahexaenoic acid, methods for its production and compounds containing the same
EP0547065A4 (en) Melanin production by transformed microorganisms
WO1990012105A3 (en) Production of amino acids by methylotrophic bacillus
DK165757C (en) BIOLOGICALLY CULTURE OF THE MICROORGANISM STREPTOMYCES ROSEOSPORUS NRRL 15998 AND A PROCEDURE FOR PREPARING ANTIBIOTIC EFFECTIVE A-21978C COMPLEX OR ANY OR CERO 'C' C 'C' 'C' FACTORS 'CO' FACTORS 'CO'
AU4418989A (en) Melanin production
CA2091918A1 (en) L-ascorbic acid production in microorganisms
EP0765938A3 (en) Fermentative production of vitamin B6
JPS5743685A (en) L-glutamic oxidase
AU1839795A (en) L-ascorbic acid production in microorganisms
AU4528497A (en) Method for producing L-glutamic acid by continuous fermentation
JPS5743684A (en) Preparation of maltose dehydrogenase
JPS57152885A (en) Preparation of aldose-1-epimerase
IE45014L (en) Antibiotic a-7413.
JPS5642592A (en) Novel antibiotic and its preparation
Bykhovsky et al. Biosynthesis of porphyrins by microorganisms.
JPS57105194A (en) Novel antibiotic xk-210 and its preparation
ES8602943A1 (en) Clavulanic acid prod. by biological cultivation
Bykhovsky et al. Application of anaerobic processes to the biosynthesis of vitamin B sub (12) and its analogs.
JPS57170190A (en) Novel antibiotic d-606 a and its preparation
JPS578789A (en) Preparation of coenzyme q10 by fermentation
JPS57186490A (en) Bacterium capable of producing antibiotics y-g665g-a and/or y-g665g-b
JPS642592A (en) Production of pyrroloquinolinequinone

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed