CA2072126A1 - Agents diuretiques a base de glutaramide substituee par un groupement cycloalkyle - Google Patents

Agents diuretiques a base de glutaramide substituee par un groupement cycloalkyle

Info

Publication number
CA2072126A1
CA2072126A1 CA002072126A CA2072126A CA2072126A1 CA 2072126 A1 CA2072126 A1 CA 2072126A1 CA 002072126 A CA002072126 A CA 002072126A CA 2072126 A CA2072126 A CA 2072126A CA 2072126 A1 CA2072126 A1 CA 2072126A1
Authority
CA
Canada
Prior art keywords
alkyl
formula
aryl
compound
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002072126A
Other languages
English (en)
Inventor
John C. Danilewicz
David Brown
Keith James
Ian T. Barnish
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2072126A1 publication Critical patent/CA2072126A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002072126A 1990-01-12 1990-12-11 Agents diuretiques a base de glutaramide substituee par un groupement cycloalkyle Abandoned CA2072126A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909000725A GB9000725D0 (en) 1990-01-12 1990-01-12 Therapeutic agents
GB9000725.3 1990-01-12

Publications (1)

Publication Number Publication Date
CA2072126A1 true CA2072126A1 (fr) 1991-07-13

Family

ID=10669202

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002072126A Abandoned CA2072126A1 (fr) 1990-01-12 1990-12-11 Agents diuretiques a base de glutaramide substituee par un groupement cycloalkyle

Country Status (8)

Country Link
EP (1) EP0513016A1 (fr)
JP (1) JPH0645581B2 (fr)
CA (1) CA2072126A1 (fr)
FI (1) FI922410A0 (fr)
GB (1) GB9000725D0 (fr)
IE (1) IE910083A1 (fr)
PT (1) PT96446A (fr)
WO (1) WO1991010644A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8469601A1 (es) 1998-04-10 2000-09-29 Pfizer Prod Inc Procedimiento para alquilar sulfonamidas impedidas estericamente
GT199900044A (es) * 1998-04-10 2000-09-14 Procedimientos para preparar haluros de fenoxifenilsulfonilo.
PA8469301A1 (es) 1998-04-10 2000-09-29 Pfizer Prod Inc Procedimientos para la preparacion de acidos hidroxamicos.
US20020052370A1 (en) * 2000-07-06 2002-05-02 Barber Christopher Gordon Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
US20020028799A1 (en) * 2000-07-06 2002-03-07 Naylor Alasdair Mark Treatment of male sexual dysfunction
HUP0303624A3 (en) 2001-03-28 2005-06-28 Pfizer N-phenpropylcyclopentyl-substituted glutaramide derivatives as nep inhibitors for fsad and process for preparation of the compounds
US6660756B2 (en) 2001-03-28 2003-12-09 Pfizer Inc. N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
AU2007312391B2 (en) 2006-10-19 2012-06-21 F. Hoffmann-La Roche Ag Imidazolone and imidazolidinone derivatives as 11b-HSD1 inhibitors for diabetes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880007441A (ko) * 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제
GB8811873D0 (en) * 1988-05-19 1988-06-22 Pfizer Ltd Therapeutic agents
GB2218983A (en) * 1988-05-27 1989-11-29 Pfizer Ltd Spiro-substituted glutaramides as diuretics
GB8812597D0 (en) * 1988-05-27 1988-06-29 Pfizer Ltd Therapeutic agents

Also Published As

Publication number Publication date
GB9000725D0 (en) 1990-03-14
FI922410A (fi) 1992-05-26
WO1991010644A1 (fr) 1991-07-25
JPH0645581B2 (ja) 1994-06-15
IE910083A1 (en) 1991-07-17
EP0513016A1 (fr) 1992-11-19
JPH05502231A (ja) 1993-04-22
FI922410A0 (fi) 1992-05-26
PT96446A (pt) 1991-10-15

Similar Documents

Publication Publication Date Title
US5362902A (en) N-(1-(2-carboxyethyl35cloalkylcarbonyl)-beta-alanine derivatives for pharmaceutical use
CA1328264C (fr) Diuretiques glutaramides a substituant spiro
EP0358398B1 (fr) Glutaramides cycloalkyl substitués comme agents antihypertensifs
CA1182125A (fr) Methode de preparation d'acides threo-3-amino-2- hydroxybutanoyl-amino-acetiques; nouveaux produits intermediaires utilises a cette fin et leur preparation
Tsang et al. Peptide sweeteners. 6. Structural studies on the C-terminal amino acid of L-aspartyl dipeptide sweeteners
PT101027A (pt) Peptideos, processo para a sua preparacao e sua utilizacao como compostos farmaceuticos
JP2002504917A (ja) ピリミジン−２，４，６−トリオン誘導体、その製造方法及びこの化合物を含有する医薬
JP2001517246A (ja) α▲下４▼β▲下１▼媒介細胞接着の阻止剤
JP2002517508A (ja) Ｃ型肝炎ウィルスｎｓ３プロテアーゼのペプチド系抑制剤
EP0184550A2 (fr) Dérivés de 5-amino-4-hydroxy valérylamides
NZ270828A (en) Lipopeptide a1437 derivative and pharmaceutical compositions thereof
KR0121793B1 (ko) L-프롤린 유도체, 이의 제조 방법 및 이를 함유하는 향정신성 생물학적 제제
CA2072126A1 (fr) Agents diuretiques a base de glutaramide substituee par un groupement cycloalkyle
EP0144290A2 (fr) Dérivés éthylènediamine substitués
FÜLÖP The chemistry of 2-aminocyclopentanecarboxylic acid
JPH01254651A (ja) Ｎ↑２−（１−カルボキシ−３−フエニルプロピル）−ｌ−リジン誘導体及び該化合物を用いるリジノプリルの製造法
JPH026452A (ja) シクロメチレン―１，２―ジカルボン酸類のアミド類
US5847125A (en) Amino acid derivatives with anticholecystokinin activity
CA1338121C (fr) Derives du 2 -aminoacetamide a activites anticonvulsivante et neuroprotectrice
JPH0517439A (ja) 光学的に活性な二環式イミノ−α−カルボン酸エステルのラセミ体の分割法で得られた化合物
US4716149A (en) Partially modified, retro-inverso neurotensin analogs
US4456594A (en) N-Carboxyalkylproline-containing tripeptides
CA1247085A (fr) Preparation de tripeptides renfermant la n-carboxyalcoylproline
US5043346A (en) Amino acid esters, pharmaceuticals containing them, and the use thereof in learning disorders
US5399748A (en) Derivatives of aspartic acid and glutamic acid having anticholecystokinin activity

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead