CA2051281A1 - Process for the preparation of triazolyl isopropanols - Google Patents
Process for the preparation of triazolyl isopropanolsInfo
- Publication number
- CA2051281A1 CA2051281A1 CA 2051281 CA2051281A CA2051281A1 CA 2051281 A1 CA2051281 A1 CA 2051281A1 CA 2051281 CA2051281 CA 2051281 CA 2051281 A CA2051281 A CA 2051281A CA 2051281 A1 CA2051281 A1 CA 2051281A1
- Authority
- CA
- Canada
- Prior art keywords
- preparation
- isopropanols
- triazolyl
- fluconazole
- halohydrinic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
An improved method for the preparation of fluconazole is described, by reacting an halohydrinic intermediate with 4-amino-1,2,4-triazole compound of formula II
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT02058690A IT1249211B (en) | 1990-06-08 | 1990-06-08 | Process for the preparation of triazolyl isopropanols, in particular fluconazole |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2051281A1 true CA2051281A1 (en) | 1993-03-14 |
CA2051281C CA2051281C (en) | 1998-07-07 |
Family
ID=11169192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2051281 Expired - Lifetime CA2051281C (en) | 1990-06-08 | 1991-09-13 | Process for the preparation of triazolyl isopropanols |
Country Status (5)
Country | Link |
---|---|
AT (1) | AT400145B (en) |
CA (1) | CA2051281C (en) |
ES (1) | ES2026416A6 (en) |
IT (1) | IT1249211B (en) |
YU (1) | YU48331B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0618198A1 (en) * | 1993-03-29 | 1994-10-05 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of 1,3-bis (1,2,4-triazol-1-yl)-propan-2-ol derivatives |
WO1995008543A1 (en) * | 1993-09-23 | 1995-03-30 | Richter Gedeon Vegyészeti Gyár Rt. | Novel substituted propane-2-ol derivatives |
WO2004000835A1 (en) * | 2002-06-24 | 2003-12-31 | Basf Aktiengesellschaft | Method for the production of 1,2,4-triazolylmethyl-oxiranes |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2049663B1 (en) * | 1992-10-13 | 1994-12-16 | Genesis Para La Investigacion | PROCEDURE FOR OBTAINING FLUCONAZOLE. |
SI9600165A (en) * | 1996-05-21 | 1997-12-31 | Krka Tovarna Zdravil D D Novo | Process for preparation of biological active derivative of 1,2,4- triazole and intermediates useful in this process |
ATE309226T1 (en) * | 2001-03-23 | 2005-11-15 | Richter Gedeon Vegyeszet | METHOD FOR PRODUCING FLUCONAZOLES AND CRYSTAL MODIFICATIONS THEREOF |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR79307B (en) * | 1982-06-09 | 1984-10-22 | Pfizer | |
ES8604938A1 (en) * | 1985-11-19 | 1986-03-01 | Inke Sa | 2-(Difluorophenyl)-1,3-bis(triazolyl) propan-2-ol prepn. |
ES8604940A1 (en) * | 1985-11-19 | 1986-03-01 | Inke Sa | 2-(Difluorophenyl) 1,3-bis(1H-triazolyl) propan-2-ol prepn. |
ES8604939A1 (en) * | 1985-11-19 | 1986-03-01 | Inke Sa | 2-(Difluorophenyl) 1,3-bis (1H-triazolyl) propan-2-ol prepn. |
ES8605753A1 (en) * | 1985-12-06 | 1986-04-16 | Lazlo Int Sa | Di-triazolyl:methyl di:fluoro-phenyl carbinol prepn. |
-
1990
- 1990-06-08 IT IT02058690A patent/IT1249211B/en active IP Right Grant
- 1990-11-21 ES ES9002961A patent/ES2026416A6/en not_active Expired - Lifetime
-
1991
- 1991-06-05 AT AT113291A patent/AT400145B/en not_active IP Right Cessation
- 1991-06-06 YU YU101291A patent/YU48331B/en unknown
- 1991-09-13 CA CA 2051281 patent/CA2051281C/en not_active Expired - Lifetime
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0618198A1 (en) * | 1993-03-29 | 1994-10-05 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of 1,3-bis (1,2,4-triazol-1-yl)-propan-2-ol derivatives |
US5484936A (en) * | 1993-03-29 | 1996-01-16 | Teva Pharmaceutical Industries Ltd. | Processes for the preparation of 1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol derivatives |
AU683443B2 (en) * | 1993-03-29 | 1997-11-13 | Teva Pharmaceutical Industries Ltd. | Processes for the preparation of 1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol derivatives |
WO1995008543A1 (en) * | 1993-09-23 | 1995-03-30 | Richter Gedeon Vegyészeti Gyár Rt. | Novel substituted propane-2-ol derivatives |
WO2004000835A1 (en) * | 2002-06-24 | 2003-12-31 | Basf Aktiengesellschaft | Method for the production of 1,2,4-triazolylmethyl-oxiranes |
CN100345841C (en) * | 2002-06-24 | 2007-10-31 | 巴斯福股份公司 | Preparation for the production of 1,2,4-triazolymethyl-oxiranes |
US7368464B2 (en) | 2002-06-24 | 2008-05-06 | Basf Aktiengesellschaft | Preparation for the production of 1,2,4-triazolylmethyl-oxiranes |
Also Published As
Publication number | Publication date |
---|---|
CA2051281C (en) | 1998-07-07 |
IT9020586A0 (en) | 1990-06-07 |
ES2026416A6 (en) | 1992-04-16 |
YU48331B (en) | 1998-05-15 |
IT1249211B (en) | 1995-02-20 |
ATA113291A (en) | 1995-02-15 |
AT400145B (en) | 1995-10-25 |
IT9020586A1 (en) | 1991-12-08 |
YU101291A (en) | 1993-11-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |