CA2015597A1 - Device and method of iontophoretic drug delivery - Google Patents
Device and method of iontophoretic drug deliveryInfo
- Publication number
- CA2015597A1 CA2015597A1 CA 2015597 CA2015597A CA2015597A1 CA 2015597 A1 CA2015597 A1 CA 2015597A1 CA 2015597 CA2015597 CA 2015597 CA 2015597 A CA2015597 A CA 2015597A CA 2015597 A1 CA2015597 A1 CA 2015597A1
- Authority
- CA
- Canada
- Prior art keywords
- agent
- ions
- molecular weight
- reservoir
- electrolyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Electrotherapy Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A selectively permeable membrane (14) is positioned between the agent reservoir (15) and the electrode (11) of a donor electrode assembly (8) in an iontophoretic delivery device (10). Optionally, an electrolyte reservoir (13) is positioned intermediate the electrode (11) and the agent reservoir (15). In certain embodiments, the membrane (14) is permeable to species of less than a predetermined molecular weight and substantially less permeable to species of greater than the predetermined molecular weight. The agent is capable of dissociating into agent ions and counter ions.
The size selectivity of the membrane (14), the molecular weight of the agent ions, the molecular weight of the counter ions, and optionally the molecular weight of the electrolyte ions are selected to (A) inhibit agent ions from interacting with the electrode (11), and from permeating into the electrolyte reservoir (13), where they might otherwise be degraded and (B) inhibit electrolyte ions, having a charge similar to that of the agent ions, from permeating into the agent reservoir (15) and competing with the agent ions for iontophoretic delivery into the patient.
The size selectivity of the membrane (14), the molecular weight of the agent ions, the molecular weight of the counter ions, and optionally the molecular weight of the electrolyte ions are selected to (A) inhibit agent ions from interacting with the electrode (11), and from permeating into the electrolyte reservoir (13), where they might otherwise be degraded and (B) inhibit electrolyte ions, having a charge similar to that of the agent ions, from permeating into the agent reservoir (15) and competing with the agent ions for iontophoretic delivery into the patient.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2015597 CA2015597C (en) | 1990-04-27 | 1990-04-27 | Device and method of iontophoretic drug delivery |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2015597 CA2015597C (en) | 1990-04-27 | 1990-04-27 | Device and method of iontophoretic drug delivery |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2015597A1 true CA2015597A1 (en) | 1991-10-27 |
CA2015597C CA2015597C (en) | 2002-06-25 |
Family
ID=4144852
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2015597 Expired - Lifetime CA2015597C (en) | 1990-04-27 | 1990-04-27 | Device and method of iontophoretic drug delivery |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2015597C (en) |
-
1990
- 1990-04-27 CA CA 2015597 patent/CA2015597C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2015597C (en) | 2002-06-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |