CA2015597A1 - Device and method of iontophoretic drug delivery - Google Patents

Device and method of iontophoretic drug delivery

Info

Publication number
CA2015597A1
CA2015597A1 CA 2015597 CA2015597A CA2015597A1 CA 2015597 A1 CA2015597 A1 CA 2015597A1 CA 2015597 CA2015597 CA 2015597 CA 2015597 A CA2015597 A CA 2015597A CA 2015597 A1 CA2015597 A1 CA 2015597A1
Authority
CA
Canada
Prior art keywords
agent
ions
molecular weight
reservoir
electrolyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2015597
Other languages
French (fr)
Other versions
CA2015597C (en
Inventor
Ronald P. Haak
J. Richard Gyory
Felix Theeuwes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Priority to CA 2015597 priority Critical patent/CA2015597C/en
Publication of CA2015597A1 publication Critical patent/CA2015597A1/en
Application granted granted Critical
Publication of CA2015597C publication Critical patent/CA2015597C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Electrotherapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A selectively permeable membrane (14) is positioned between the agent reservoir (15) and the electrode (11) of a donor electrode assembly (8) in an iontophoretic delivery device (10). Optionally, an electrolyte reservoir (13) is positioned intermediate the electrode (11) and the agent reservoir (15). In certain embodiments, the membrane (14) is permeable to species of less than a predetermined molecular weight and substantially less permeable to species of greater than the predetermined molecular weight. The agent is capable of dissociating into agent ions and counter ions.
The size selectivity of the membrane (14), the molecular weight of the agent ions, the molecular weight of the counter ions, and optionally the molecular weight of the electrolyte ions are selected to (A) inhibit agent ions from interacting with the electrode (11), and from permeating into the electrolyte reservoir (13), where they might otherwise be degraded and (B) inhibit electrolyte ions, having a charge similar to that of the agent ions, from permeating into the agent reservoir (15) and competing with the agent ions for iontophoretic delivery into the patient.
CA 2015597 1990-04-27 1990-04-27 Device and method of iontophoretic drug delivery Expired - Lifetime CA2015597C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA 2015597 CA2015597C (en) 1990-04-27 1990-04-27 Device and method of iontophoretic drug delivery

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 2015597 CA2015597C (en) 1990-04-27 1990-04-27 Device and method of iontophoretic drug delivery

Publications (2)

Publication Number Publication Date
CA2015597A1 true CA2015597A1 (en) 1991-10-27
CA2015597C CA2015597C (en) 2002-06-25

Family

ID=4144852

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2015597 Expired - Lifetime CA2015597C (en) 1990-04-27 1990-04-27 Device and method of iontophoretic drug delivery

Country Status (1)

Country Link
CA (1) CA2015597C (en)

Also Published As

Publication number Publication date
CA2015597C (en) 2002-06-25

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