CA2002318A1 - Adn encodant des polypeptides¬lys46,asp97,asp113|et¬lys46,asp113,as137p}thaumatine i - Google Patents
Adn encodant des polypeptides¬lys46,asp97,asp113|et¬lys46,asp113,as137p}thaumatine iInfo
- Publication number
- CA2002318A1 CA2002318A1 CA2002318A CA2002318A CA2002318A1 CA 2002318 A1 CA2002318 A1 CA 2002318A1 CA 2002318 A CA2002318 A CA 2002318A CA 2002318 A CA2002318 A CA 2002318A CA 2002318 A1 CA2002318 A1 CA 2002318A1
- Authority
- CA
- Canada
- Prior art keywords
- lys46
- asp97
- thaumatin
- polypeptides
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 235000010436 thaumatin Nutrition 0.000 title 1
- 239000000892 thaumatin Substances 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
- 239000004472 Lysine Substances 0.000 abstract 2
- 101710135233 Thaumatin I Proteins 0.000 abstract 2
- 229960001230 asparagine Drugs 0.000 abstract 2
- 235000009582 asparagine Nutrition 0.000 abstract 2
- 229940009098 aspartate Drugs 0.000 abstract 2
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- C07K14/43—Sweetening agents, e.g. thaumatin, monellin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26870288A | 1988-11-08 | 1988-11-08 | |
US268,702 | 1988-11-08 | ||
US407,416 | 1989-09-14 | ||
US07/407,416 US5221624A (en) | 1988-11-08 | 1989-09-14 | DNA encoding (Lys46, Asp97, Asp113) and (Lys46, Asp.sup.137) thaumatin I polypeptides |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2002318A1 true CA2002318A1 (fr) | 1990-05-08 |
CA2002318C CA2002318C (fr) | 2000-05-23 |
Family
ID=26953274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002002318A Expired - Fee Related CA2002318C (fr) | 1988-11-08 | 1989-11-06 | Adn encodant des polypeptides¬lys46,asp97,asp113|et¬lys46,asp113,as137p}thaumatine i |
Country Status (8)
Country | Link |
---|---|
US (1) | US5221624A (fr) |
EP (1) | EP0396741B1 (fr) |
JP (1) | JPH03502645A (fr) |
AT (1) | ATE142687T1 (fr) |
AU (2) | AU625879B2 (fr) |
CA (1) | CA2002318C (fr) |
DE (1) | DE68927167T2 (fr) |
WO (1) | WO1990005775A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5234834A (en) * | 1987-06-19 | 1993-08-10 | The Regents Of The University Of California | Constructs for expression of monellin in plant cells |
ES2080689B1 (es) * | 1994-04-21 | 1996-09-01 | Urquima Sa | Procedimiento de obtencion de un edulcorante natural proteico. |
AU6674296A (en) * | 1995-06-23 | 1997-01-22 | University Of Hawaii | Recombinant sweet protein mabinlin |
GB9724307D0 (en) * | 1997-11-17 | 1998-01-14 | Zeneca Ltd | Improvements relating to protein accumulation |
US6274707B1 (en) | 1999-04-14 | 2001-08-14 | Wisconsin Alumni Research Foundation | Protein sweetener |
US6420527B1 (en) * | 1999-05-06 | 2002-07-16 | International Flavors & Fragrances Inc. | Flavor active modified thaumatin and monellin and methods for their production and use |
US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
KR101083040B1 (ko) | 2010-02-24 | 2011-11-16 | 중앙대학교 산학협력단 | 높은 단맛을 가지는 신규한 브라제인 다중 변이체 및 이의 제조방법 |
WO2011105841A2 (fr) * | 2010-02-24 | 2011-09-01 | 중앙대학교 산학협력단 | Vecteur d'expression recombinant pour exprimer la brazzéine, et variante de brazzéine à mutation multiple dont la douceur est supérieure |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3177281T2 (de) * | 1980-12-12 | 1992-12-10 | Unilever Nv | Strukturgene, die fuer die verschiedenen allelischen und reifungsformen von praeprothaumatin und deren mutanten kodieren, diese strukturgene enthaltende klonierungsvektoren und deren expression in mikrobiellen wirtzellen. |
HU204097B (en) * | 1982-05-19 | 1991-11-28 | Gist Brocades Nv | Process for producing cloning system relating to kluyveromyces species |
US4546082A (en) * | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
AU577334B2 (en) * | 1983-10-11 | 1988-09-22 | International Genetic Engineering, Inc. | Synthetic thaumatin genes |
CA1310923C (fr) * | 1985-11-13 | 1992-12-01 | Joachim Ludwig Weickmann | Adn encodant la [asp --]- et la [lys -, asp --] -thaumatine i |
AU621277B2 (en) * | 1985-11-13 | 1992-03-12 | Xoma Corporation | Shortened phosphoglycerate kinase promoter |
US4766205A (en) * | 1985-11-13 | 1988-08-23 | Beatrice Companies, Inc. | Method for isolation of recombinant polypeptides in biologically active forms |
IL82935A0 (en) * | 1986-08-12 | 1987-12-20 | Phillips Petroleum Co | Secretion of heterologous proteins from yeast |
-
1989
- 1989-09-14 US US07/407,416 patent/US5221624A/en not_active Expired - Lifetime
- 1989-11-06 DE DE68927167T patent/DE68927167T2/de not_active Expired - Fee Related
- 1989-11-06 CA CA002002318A patent/CA2002318C/fr not_active Expired - Fee Related
- 1989-11-06 AU AU50450/90A patent/AU625879B2/en not_active Ceased
- 1989-11-06 WO PCT/US1989/005018 patent/WO1990005775A1/fr active IP Right Grant
- 1989-11-06 EP EP90902746A patent/EP0396741B1/fr not_active Expired - Lifetime
- 1989-11-06 AT AT90902746T patent/ATE142687T1/de not_active IP Right Cessation
- 1989-11-06 JP JP2503046A patent/JPH03502645A/ja active Pending
-
1992
- 1992-10-15 AU AU27070/92A patent/AU651501B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
JPH03502645A (ja) | 1991-06-20 |
AU5045090A (en) | 1990-06-12 |
AU2707092A (en) | 1992-12-17 |
AU625879B2 (en) | 1992-07-16 |
ATE142687T1 (de) | 1996-09-15 |
CA2002318C (fr) | 2000-05-23 |
WO1990005775A1 (fr) | 1990-05-31 |
US5221624A (en) | 1993-06-22 |
AU651501B2 (en) | 1994-07-21 |
EP0396741A1 (fr) | 1990-11-14 |
EP0396741A4 (en) | 1992-03-11 |
DE68927167T2 (de) | 1997-04-03 |
DE68927167D1 (de) | 1996-10-17 |
EP0396741B1 (fr) | 1996-09-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |