CA1338445C - Oxydes de 1,2,4-benzotriazine, radiosensibilisateurs et agents cytotoxiques selectifs - Google Patents
Oxydes de 1,2,4-benzotriazine, radiosensibilisateurs et agents cytotoxiques selectifsInfo
- Publication number
- CA1338445C CA1338445C CA000540932A CA540932A CA1338445C CA 1338445 C CA1338445 C CA 1338445C CA 000540932 A CA000540932 A CA 000540932A CA 540932 A CA540932 A CA 540932A CA 1338445 C CA1338445 C CA 1338445C
- Authority
- CA
- Canada
- Prior art keywords
- amino
- hydrocarbyl
- hydroxy
- independently
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91190686A | 1986-09-25 | 1986-09-25 | |
US911,906 | 1986-09-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1338445C true CA1338445C (fr) | 1996-07-09 |
Family
ID=25431084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000540932A Expired - Fee Related CA1338445C (fr) | 1986-09-25 | 1987-06-30 | Oxydes de 1,2,4-benzotriazine, radiosensibilisateurs et agents cytotoxiques selectifs |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP2668232B2 (fr) |
CA (1) | CA1338445C (fr) |
DE (2) | DE3790581T1 (fr) |
GB (1) | GB2203151B (fr) |
WO (1) | WO1988002366A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5624925A (en) | 1986-09-25 | 1997-04-29 | Sri International | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents |
US5175287A (en) * | 1986-09-25 | 1992-12-29 | S R I International | Process for preparing 1,2,4-benzotriazine oxides |
IE62911B1 (en) * | 1988-03-18 | 1995-03-08 | Stanford Res Inst Int | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents |
GR1000941B (el) * | 1989-03-17 | 1993-03-16 | Stanford Res Inst Int | Μεθοδος παρασκευης οξειδιων 1,2,4,βενζοτριαζινης. |
DE68929050T2 (de) | 1989-09-18 | 2000-02-03 | Stanford Res Inst Int | 1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel |
US5672702A (en) * | 1995-12-04 | 1997-09-30 | Sanofi | Process for preparing 3 amino 1, 2, 4-benzotriazine dioxide |
CN104105692B (zh) * | 2011-12-07 | 2016-06-29 | 思研(Sri)国际顾问与咨询公司 | 作为结核分枝杆菌靶向药物的苯并三嗪氧化物 |
WO2015098963A1 (fr) | 2013-12-26 | 2015-07-02 | 東亞合成株式会社 | Procédé permettant de promouvoir l'expression de la calréticuline, et peptide synthétique pouvant être utilisé dans ledit procédé |
JP6872713B2 (ja) | 2015-05-29 | 2021-05-19 | 東亞合成株式会社 | 腫瘍細胞の放射線感受性を増大させる合成ペプチド及びその利用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2489352A (en) * | 1946-04-10 | 1949-11-29 | Merck & Co Inc | Halogen compounds of 3 aminobenzotriazine 1, 2, 4 oxide-1 |
US2489359A (en) * | 1947-01-10 | 1949-11-29 | Merck & Co Inc | Benzotriazines |
CH487171A (de) * | 1963-10-22 | 1970-03-15 | Siegfried Ag | Verfahren zur Herstellung therapeutisch wirksamer 1,2-Dihydro-1,2,4-benztriazine |
DE1809390A1 (de) * | 1968-11-16 | 1970-06-11 | Bayer Ag | Phosphor-,Phosphon- bzw.Thionophosphor-(-phosphon)-saeureester und Verfahren zu ihrer Herstellung |
IE38778B1 (en) * | 1973-02-02 | 1978-05-24 | Ciba Geigy | New 1,2,4-benzotriazine derivatives |
DE2538179C2 (de) * | 1975-08-27 | 1986-05-28 | Bayer Ag, 5090 Leverkusen | 3-Alkoxy-benzo-1,2,4-triazine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide |
DE2740887A1 (de) * | 1977-09-10 | 1979-03-22 | Bayer Ag | Mittel zur bekaempfung von pflanzenbakteriosen |
-
1987
- 1987-06-16 GB GB8810634A patent/GB2203151B/en not_active Expired - Lifetime
- 1987-06-16 DE DE19873790581 patent/DE3790581T1/de active Pending
- 1987-06-16 DE DE3790581A patent/DE3790581B4/de not_active Expired - Lifetime
- 1987-06-16 JP JP62504083A patent/JP2668232B2/ja not_active Expired - Lifetime
- 1987-06-16 WO PCT/US1987/001412 patent/WO1988002366A1/fr active Application Filing
- 1987-06-30 CA CA000540932A patent/CA1338445C/fr not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE3790581B4 (de) | 2004-12-23 |
JP2668232B2 (ja) | 1997-10-27 |
GB2203151B (en) | 1991-05-29 |
GB8810634D0 (en) | 1988-07-06 |
GB2203151A (en) | 1988-10-12 |
DE3790581T1 (fr) | 1988-08-25 |
WO1988002366A1 (fr) | 1988-04-07 |
JPH01500826A (ja) | 1989-03-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6828321B2 (en) | 1,2,4-Benzotriazine oxides as radiosensitizers and selective cytotoxic agents | |
US5175287A (en) | Process for preparing 1,2,4-benzotriazine oxides | |
US6277835B1 (en) | Method of tumor treatment | |
US5041653A (en) | Substituted benzamide radiosensitizers | |
US5032617A (en) | Substituted benzamide radiosensitizers | |
CA1338445C (fr) | Oxydes de 1,2,4-benzotriazine, radiosensibilisateurs et agents cytotoxiques selectifs | |
AU646794B2 (en) | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents | |
CA1339217C (fr) | Oxydes de 1,2,4-benzotriazine, agents de sensibilisation et cytotoxiquesselectifs | |
CA2001903C (fr) | Oxydes de 1,2,4-benzotriazine utilises comme radiosensibilisants et agents cytotoxiques selectifs | |
KR19990079186A (ko) | 방사선 감응제 및 선택적인 세포독성제로서의 1,2,4-벤조트리아진 산화물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MKLA | Lapsed |